TY - JOUR
T1 - Anxiety and depression in Klinefelter syndrome
T2 - The impact of personality and social engagement
AU - Skakkebæk, Anne
AU - Moore, Philip J.
AU - Pedersen, Anders Degn
AU - Bojesen, Anders
AU - Kristensen, Maria Krarup
AU - Fedder, Jens
AU - Hertz, Jens Michael
AU - Østergaard, John R.
AU - Wallentin, Mikkel
AU - Gravholt, Claus Højbjerg
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.
AB - Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.
KW - Adult
KW - Anxiety/epidemiology
KW - Depression/epidemiology
KW - Humans
KW - Klinefelter Syndrome/epidemiology
KW - Male
KW - Middle Aged
KW - Neuroticism
KW - Personality Inventory
KW - Prevalence
KW - Social Participation/psychology
U2 - 10.1371/journal.pone.0206932
DO - 10.1371/journal.pone.0206932
M3 - Journal article
C2 - 30412595
AN - SCOPUS:85056314493
SN - 1932-6203
VL - 13
JO - PLOS ONE
JF - PLOS ONE
IS - 11
M1 - e0206932
ER -