Antiobesity mechanisms of action of conjugated linoleic acid

Arion Kennedy, Kristina Martinez, Soren Schmidt, Susanne Mandrup, Kathleen LaPoint, Michael McIntosh

Research output: Contribution to journalJournal articleResearchpeer-review


Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.
Original languageEnglish
JournalThe Journal of Nutritional Biochemistry
Issue number3
Pages (from-to)171-9
Number of pages9
Publication statusPublished - 1. Mar 2010


  • Adipogenesis
  • Adiposity
  • Animals
  • Apoptosis
  • Body Weight
  • Dietary Fats, Unsaturated
  • Dietary Supplements
  • Energy Metabolism
  • Humans
  • Inflammation
  • Linoleic Acids, Conjugated
  • Lipid Metabolism
  • Obesity
  • Species Specificity


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