Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity

Xiangmiao Qiu, Bianca Zingano, Shixu He, Xi Zhu, Anjiao Peng, Jianan Duan, Peter Wolf, Lei Chen*

*Corresponding author for this work

Research output: Contribution to journalComment/debateResearchpeer-review

Abstract

Depression is relatively common among patients with epilepsy, but often with predominant atypical symptoms. Some antiepileptic drugs show positive psychotropic effects, but these are not always sufficient to stabilize mood in epilepsy patients. Antidepressants are recommended to treat atypical depression but are not always effective and present a certain risk of seizure provocation. Thus, new treatment options are welcome. Here, we describe three cases of refractory epilepsy with atypical depression in which olanzapine, contrary to its earlier reported proconvulsant effect, showed excellent antidepressant action and resulted in seizure control. Possible mechanisms of this action are discussed.

Original languageEnglish
JournalEpileptic Disorders
Volume20
Issue number3
Pages (from-to)225-231
ISSN1294-9361
DOIs
Publication statusPublished - 1. Jun 2018

Keywords

  • bipolar disorder
  • depression
  • epilepsy
  • interictal dysphoric disorder
  • olanzapine
  • Depressive Disorder/complications
  • Olanzapine
  • Humans
  • Treatment Outcome
  • Anticonvulsants/therapeutic use
  • Young Adult
  • Epilepsy/complications
  • Adult
  • Antidepressive Agents/therapeutic use
  • Female
  • Benzodiazepines/therapeutic use

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    Qiu, X., Zingano, B., He, S., Zhu, X., Peng, A., Duan, J., Wolf, P., & Chen, L. (2018). Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity. Epileptic Disorders, 20(3), 225-231. https://doi.org/10.1684/epd.2018.0977