Abstract
Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant bacteria, such as methicillin-resistant staphylococcus aureus (MRSA) may be treated effectively.
| Original language | English |
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| IPC | A61K31/4192,A61K31/52,A61P31/04,C07D249/06,C07D403/10,C07D473/02 |
| Patent number | WO2021219813 (A1) |
| Filing date | 11/04/2021 |
| Country/Territory | Denmark |
| Priority date | 01/05/2020 |
| Priority number | EP20200172580 |
| Publication status | Published - 4. Nov 2021 |