Antacid Treatment of Duodenal Ulcer

ULRIK BECKER*, KAREN LINDORFF, CARSTEN ANDERSEN, POUL JØRGEN RANLØV

*Corresponding author for this work

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Abstract

ABSTRACT. Becker U, Lindorff K, Andersen C, Ranløv PJ (Department of Internal Medicine B, Central Hospital, Hillerød, Denmark). Antacid treatment of duodenal ulcer. Acta Med Scand 1987; 221:95–101. Sixty‐seven consecutive outpatients with endoscopically verified duodenal ulcer were randomised to a double‐blind treatment with either 10 ml of an antacid suspension (buffering capacity 85 mmol/10 ml, packed in single dosage pads) 1 and 3 h after each meal and at bedtime or cimetidine 400 mg b.i.d. The double‐dummy technique was employed. Endoscopy was performed after 4 weeks treatment and, if the ulcer had not healed, after 8 weeks treatment. When ulcer healing had occurred, the patient entered a 1 year follow‐up study. The cumulative healing rates after 4 and 8 weeks treatment were 83 and 97% vs. 69 and 94% in the antacid and cimetidine groups respectively. No significant differences were observed between the treatment groups regarding ulcer healing, symptom relief or compliance. Adverse reactions were few and only 3 (9%) patients in the antacid group had to discontinue the treatment due to diarrhoea. Of the cimetidine treated patients, 61% had symptomatic relapse during the 1 year follow‐up compared to 71% of the antacid treated patients. There were no significant differences in recurrence rate or time to relapse. The moderate dose antacid treatment used here is efficient, well tolerated, safe, convenient and is a good alternative treatment of the duodenal ulcer patient. 1987 Association for the Publication of the Journal of Internal Medicine

Original languageEnglish
JournalACTA MEDICA SCANDINAVICA
Volume221
Issue number1
Pages (from-to)95-101
Number of pages7
ISSN0001-6101
DOIs
Publication statusPublished - 1. Jan 1987

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Keywords

  • antacid
  • cimetidine
  • duodenai ulcer
  • healing
  • relapse

Cite this

BECKER, ULRIK., LINDORFF, KAREN., ANDERSEN, CARSTEN., & RANLØV, POUL. JØRGEN. (1987). Antacid Treatment of Duodenal Ulcer. ACTA MEDICA SCANDINAVICA, 221(1), 95-101. https://doi.org/10.1111/j.0954-6820.1987.tb01249.x