TY - JOUR
T1 - Analysis of patterns of bacteremia and 30-day mortality in patients with acute cholangitis over a 25-year period
AU - Tan, Ming
AU - Jensen, Thøger Gorm
AU - Nielsen, Stig Lønberg
AU - Schaffalitzky, Ove B.
AU - Laursen, Stig Borbjerg
PY - 2021/3/25
Y1 - 2021/3/25
N2 - Introduction: Acute cholangitis (AC) is a condition of bacterial infection in the biliary tract with a high mortality rate of around 10%. Direct association between presence of bacteremia and 30-day mortality among AC patients is sparsely investigated and remains unclear. Aims and methods: Our aim was to investigate association between bacteremia and 30-day mortality among patients with AC included over a period of 25 years. All AC patients that underwent endoscopic retrograde cholangiopancreatography (ERCP) at Odense University Hospital, between 1 January 1990 and 31 October 2015, were identified using a prospective ERCP database. Blood culture results from the patients along with antimicrobial resistance patterns were collected from a bacteremia research database. Results: During the study period, 775 consecutive AC patients underwent ERCP and blood cultures were collected from 528 patients. Among these patients 48% (n = 260) had bacteremia. Overall, 30-day mortality in patients with blood cultures performed was 13% (n = 69). In patients with bacteremia, 30-day mortality was 19% (n = 49), compared to 7% (n = 20) in patients without bacteremia (p <.01). Presence of bacteremia was associated with increased 30-day mortality (OR [95% CI]: 3.43 [1.92–6.13]; p <.01) following adjustment for confounding factors. Among the species, bacteremia with Enterobacter cloacae was significantly associated with increased 30-day mortality (OR [95% CI]: 2.97 [1.16–7.62]; p =.02). Conclusion: Our results indicate that presence of bacteremia was associated with a nearly fourfold increase in 30-day mortality among AC patients.
AB - Introduction: Acute cholangitis (AC) is a condition of bacterial infection in the biliary tract with a high mortality rate of around 10%. Direct association between presence of bacteremia and 30-day mortality among AC patients is sparsely investigated and remains unclear. Aims and methods: Our aim was to investigate association between bacteremia and 30-day mortality among patients with AC included over a period of 25 years. All AC patients that underwent endoscopic retrograde cholangiopancreatography (ERCP) at Odense University Hospital, between 1 January 1990 and 31 October 2015, were identified using a prospective ERCP database. Blood culture results from the patients along with antimicrobial resistance patterns were collected from a bacteremia research database. Results: During the study period, 775 consecutive AC patients underwent ERCP and blood cultures were collected from 528 patients. Among these patients 48% (n = 260) had bacteremia. Overall, 30-day mortality in patients with blood cultures performed was 13% (n = 69). In patients with bacteremia, 30-day mortality was 19% (n = 49), compared to 7% (n = 20) in patients without bacteremia (p <.01). Presence of bacteremia was associated with increased 30-day mortality (OR [95% CI]: 3.43 [1.92–6.13]; p <.01) following adjustment for confounding factors. Among the species, bacteremia with Enterobacter cloacae was significantly associated with increased 30-day mortality (OR [95% CI]: 2.97 [1.16–7.62]; p =.02). Conclusion: Our results indicate that presence of bacteremia was associated with a nearly fourfold increase in 30-day mortality among AC patients.
KW - Acute cholangitis
KW - antimicrobial resistance
KW - bacteremia
KW - endoscopic retrograde cholangiopancreatography
KW - mortality
KW - pathogens
U2 - 10.1080/00365521.2021.1902558
DO - 10.1080/00365521.2021.1902558
M3 - Journal article
C2 - 33764841
SN - 0036-5521
VL - 56
SP - 578
EP - 584
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 5
ER -