An international perspective on hospitalized patients with viral community-acquired pneumonia

Uffe Bødtger, GLIMP Study Group

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.

METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.

RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.

CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

Original languageEnglish
JournalEuropean Journal of Internal Medicine
Volume60
Pages (from-to)54-70
ISSN0953-6205
DOIs
Publication statusPublished - Feb 2019

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Viruses
Orthomyxoviridae
Nose
Ventilation
Multivariate Analysis
Cross-Sectional Studies

Keywords

  • Pneumonia
  • Infectious diseases
  • Admission
  • Oseltamivir
  • Viral pneumonia
  • Community acquired pneumonia
  • Influenza
  • Testing
  • Viral swab

Cite this

@article{d4768601017945bdaabb670fab2a960f,
title = "An international perspective on hospitalized patients with viral community-acquired pneumonia",
abstract = "BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9{\%}) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4{\%}) patients. Influenza virus was isolated in 80.9{\%} of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95{\%}CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95{\%}CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1{\%}.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.",
keywords = "Pneumonia, Infectious diseases, Admission, Oseltamivir, Viral pneumonia, Community acquired pneumonia, Influenza, Testing, Viral swab",
author = "Dejan Radovanovic and Giovanni Sotgiu and Mateja Jankovic and Mahesh, {Padukudru Anand} and Marcos, {Pedro Jorge} and Abdalla, {Mohamed I} and {Di Pasquale}, {Marta Francesca} and Andrea Gramegna and Silvia Terraneo and Francesco Blasi and Pierachille Santus and Stefano Aliberti and Reyes, {Luis F} and Restrepo, {Marcos I} and Aruj, {Patricia Karina} and Silvia Attorri and Enrique Barimboim and Caeiro, {Juan Pablo} and Garz{\'o}n, {Mar{\'i}a I} and Cambursano, {Victor Hugo} and Adrian Ceccato and Julio Chertcoff and {Cordon D{\'i}az}, Ariel and {de Vedia}, Lautaro and Ganaha, {Maria Cristina} and Sandra Lambert and Gustavo Lopardo and Luna, {Carlos M} and Malberti, {Alessio Gerardo} and Nora Morcillo and Silvina Tartara and Claudia Pensotti and Betiana Pereyra and Scapellato, {Pablo Gustavo} and Stagnaro, {Juan Pablo} and Sonali Shah and Felix L{\"o}tsch and Florian Thalhammer and Kurt Anseeuw and Francois, {Camille A} and {Van Braeckel}, Eva and Vincent, {Jean Louis} and Djimon, {Marcel Zannou} and {Aranha Nou{\'e}r}, Simone and Peter Chipev and Milena Encheva and Darina Miteva and Diana Petkova and Balkissou, {Adamou Dodo} and {Pefura Yone}, {Eric Walter} and Uffe B{\o}dtger and {GLIMP Study Group}",
note = "Copyright {\circledC} 2018 European Federation of Internal Medicine. All rights reserved.",
year = "2019",
month = "2",
doi = "10.1016/j.ejim.2018.10.020",
language = "English",
volume = "60",
pages = "54--70",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier",

}

An international perspective on hospitalized patients with viral community-acquired pneumonia. / Bødtger, Uffe; GLIMP Study Group.

In: European Journal of Internal Medicine, Vol. 60, 02.2019, p. 54-70.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - An international perspective on hospitalized patients with viral community-acquired pneumonia

AU - Radovanovic, Dejan

AU - Sotgiu, Giovanni

AU - Jankovic, Mateja

AU - Mahesh, Padukudru Anand

AU - Marcos, Pedro Jorge

AU - Abdalla, Mohamed I

AU - Di Pasquale, Marta Francesca

AU - Gramegna, Andrea

AU - Terraneo, Silvia

AU - Blasi, Francesco

AU - Santus, Pierachille

AU - Aliberti, Stefano

AU - Reyes, Luis F

AU - Restrepo, Marcos I

AU - Aruj, Patricia Karina

AU - Attorri, Silvia

AU - Barimboim, Enrique

AU - Caeiro, Juan Pablo

AU - Garzón, María I

AU - Cambursano, Victor Hugo

AU - Ceccato, Adrian

AU - Chertcoff, Julio

AU - Cordon Díaz, Ariel

AU - de Vedia, Lautaro

AU - Ganaha, Maria Cristina

AU - Lambert, Sandra

AU - Lopardo, Gustavo

AU - Luna, Carlos M

AU - Malberti, Alessio Gerardo

AU - Morcillo, Nora

AU - Tartara, Silvina

AU - Pensotti, Claudia

AU - Pereyra, Betiana

AU - Scapellato, Pablo Gustavo

AU - Stagnaro, Juan Pablo

AU - Shah, Sonali

AU - Lötsch, Felix

AU - Thalhammer, Florian

AU - Anseeuw, Kurt

AU - Francois, Camille A

AU - Van Braeckel, Eva

AU - Vincent, Jean Louis

AU - Djimon, Marcel Zannou

AU - Aranha Nouér, Simone

AU - Chipev, Peter

AU - Encheva, Milena

AU - Miteva, Darina

AU - Petkova, Diana

AU - Balkissou, Adamou Dodo

AU - Pefura Yone, Eric Walter

AU - Bødtger, Uffe

AU - GLIMP Study Group

N1 - Copyright © 2018 European Federation of Internal Medicine. All rights reserved.

PY - 2019/2

Y1 - 2019/2

N2 - BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

AB - BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.RESULTS: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.CONCLUSION: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

KW - Pneumonia

KW - Infectious diseases

KW - Admission

KW - Oseltamivir

KW - Viral pneumonia

KW - Community acquired pneumonia

KW - Influenza

KW - Testing

KW - Viral swab

U2 - 10.1016/j.ejim.2018.10.020

DO - 10.1016/j.ejim.2018.10.020

M3 - Journal article

VL - 60

SP - 54

EP - 70

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

ER -