AMPK inhibitors

Trond Ulven (Inventor)

Research output: Patent

Abstract

The 5'-AMP-activated protein kinase AMPK functions as a master switch to maintain cellular and whole-body energy homeostasis and abnormal activity profiles of AMPK may cause pathological disorders. The present invention relates to a series of compounds (I) based on a pyrrolo[2,3-c]pyridine and a thieno[2,3- c]pyridine scaffold as AMPK inhibitors. In particular, the present invention relates to the synthesis of such compounds and the medical use of such compounds
Original languageEnglish
IPCA61K31/4365,A61K31/437,A61P25/00,A61P35/00,C07D471/04,C07D495/04
Patent numberWO2019106087A1
Filing date29/11/2018
Country/TerritoryDenmark
Priority date29/11/2017
Priority numberEP20170204381
Publication statusPublished - 6. Jun 2019

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