Altered subcellular localization of ornithine decarboxylase in Alzheimer's disease brain

Tatjana Nilsson, Nenad Bogdanovic, Inga Volkman, Bengt Winblad, Ronnie Folkesson, Eirikur Benedikz

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The amyloid precursor protein can through ligand-mimicking induce expression of ornithine decarboxylase (ODC), the initial and rate-limiting enzyme in polyamine biosynthesis. We report here the regional distribution and cellular localization of ODC immunoreactivity in Alzheimer's disease (AD) brains. In frontal cortex and hippocampus of control cases, the most pronounced ODC immunoreactivity was found in the nucleus. In possible and definite AD the immunoreactivity had shifted to the cytoplasm. In cerebellum of control cases, ODC staining was found in a small portion of Purkinje cells, mostly in the nucleus. In AD, both possible and definite, the number of stained Purkinje cells increased significantly and immunoreactivity was shifted to the cytoplasm, even though it was still prominent in the nucleus. In conclusion, our study reveals an early shift of the ODC immunoreactivity in AD from the nuclear compartment towards the cytoplasm.
Original languageEnglish
JournalBiochemical and Biophysical Research Communications
Volume344
Issue number2
Pages (from-to)640-6
Number of pages7
ISSN0006-291X
DOIs
Publication statusPublished - 2006

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Keywords

  • Aged
  • Alzheimer Disease
  • Brain
  • Humans
  • Ornithine Decarboxylase
  • Subcellular Fractions
  • Tissue Distribution

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