Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission

J G Jespersen, U R Mikkelsen, A Nedergaard, Jonas Bloch Thorlund, P Schjerling, C Suetta, P A Christensen, Per Aagaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and strength are necessary in combat or evacuation situations, which prompt for improved understanding of muscle mass modulation during SSR missions. To explore the molecular regulation of myofiber size during a simulated SSR operation, nine male Special Forces soldiers were biopsied in m. vastus lateralis pre and post 8 days immobilizing restricted prone position. After immobilization, total mammalian target of rapamycin protein was reduced by 42% (P 
Original languageEnglish
JournalScandinavian Journal of Medicine & Science in Sports
Volume25
Issue number2
Pages (from-to)175–183
Number of pages9
ISSN0905-7188
DOIs
Publication statusPublished - Apr 2015

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Military Personnel
Immobilization
Muscles
Prone Position
Quadriceps Muscle

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Jespersen, J G ; Mikkelsen, U R ; Nedergaard, A ; Thorlund, Jonas Bloch ; Schjerling, P ; Suetta, C ; Christensen, P A ; Aagaard, Per. / Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission. In: Scandinavian Journal of Medicine & Science in Sports. 2015 ; Vol. 25, No. 2. pp. 175–183.
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abstract = "In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and strength are necessary in combat or evacuation situations, which prompt for improved understanding of muscle mass modulation during SSR missions. To explore the molecular regulation of myofiber size during a simulated SSR operation, nine male Special Forces soldiers were biopsied in m. vastus lateralis pre and post 8 days immobilizing restricted prone position. After immobilization, total mammalian target of rapamycin protein was reduced by 42{\%} (P ",
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Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission. / Jespersen, J G; Mikkelsen, U R; Nedergaard, A; Thorlund, Jonas Bloch; Schjerling, P; Suetta, C; Christensen, P A; Aagaard, Per.

In: Scandinavian Journal of Medicine & Science in Sports, Vol. 25, No. 2, 04.2015, p. 175–183.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - Alterations in molecular muscle mass regulators after 8 days immobilizing Special Forces mission

AU - Jespersen, J G

AU - Mikkelsen, U R

AU - Nedergaard, A

AU - Thorlund, Jonas Bloch

AU - Schjerling, P

AU - Suetta, C

AU - Christensen, P A

AU - Aagaard, Per

N1 - Article first published online: 15 JAN 2014

PY - 2015/4

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AB - In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and strength are necessary in combat or evacuation situations, which prompt for improved understanding of muscle mass modulation during SSR missions. To explore the molecular regulation of myofiber size during a simulated SSR operation, nine male Special Forces soldiers were biopsied in m. vastus lateralis pre and post 8 days immobilizing restricted prone position. After immobilization, total mammalian target of rapamycin protein was reduced by 42% (P 

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JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

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