Alliances of the gut and bone axis

Morten Steen Hansen, Morten Frost*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate metabolic processes including glucose homeostasis and food intake, and several of these gut hormones are involved in the regulation of the energy demanding process of bone remodelling. Here, we review the gut hormones considered or known to be involved in the gut-bone crosstalk and their role in orchestrating adaptions of bone formation and resorption as demonstrated in cellular and physiological experiments and clinical trials. Understanding the physiology and pathophysiology of the gut-bone axis may identify adverse effects of investigational drugs aimed to treat metabolic diseases such as type 2 diabetes and obesity and new therapeutic candidates for the treatment of bone diseases.

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
Pages (from-to)74-81
Publication statusPublished - Mar 2022


  • Bone metabolism
  • Bone remodelling
  • Gut hormones
  • Gut-bone axis
  • Therapeutic targets


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