Aldersrelaterede forskelle i kræftbiologi hos ældre

Translated title of the contribution: Age-related differences in cancer biology in older patients

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Abstract

Aging impacts cancer development with incidence rising exponentially. Age-related genetic and epigenetic changes, along with the aging microenvironment, contribute to cancer development. In older individuals, tumours manifest a heightened mutational burden and distinct genetic changes which differ significantly from tumours observed in younger patients. The aging microenvironment accumulates senescent cells, altered matrix, and a dysregulated immune system. Age-related changes in the immune system fuel tumour development and treatment resistance. Understanding these processes is crucial for optimized treatment of older patients with cancer, as discussed in this review.
Translated title of the contributionAge-related differences in cancer biology in older patients
Original languageDanish
Article numberV07230474
JournalUgeskrift for Læger
Volume186
Issue number2
Pages (from-to)135-138
ISSN0041-5782
Publication statusPublished - 22. Jan 2024

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