Abstract
Aging impacts cancer development with incidence rising exponentially. Age-related genetic and epigenetic changes, along with the aging microenvironment, contribute to cancer development. In older individuals, tumours manifest a heightened mutational burden and distinct genetic changes which differ significantly from tumours observed in younger patients. The aging microenvironment accumulates senescent cells, altered matrix, and a dysregulated immune system. Age-related changes in the immune system fuel tumour development and treatment resistance. Understanding these processes is crucial for optimized treatment of older patients with cancer, as discussed in this review.
| Translated title of the contribution | Age-related differences in cancer biology in older patients |
|---|---|
| Original language | Danish |
| Article number | V07230474 |
| Journal | Ugeskrift for Læger |
| Volume | 186 |
| Issue number | 2 |
| Pages (from-to) | 135-138 |
| ISSN | 0041-5782 |
| Publication status | Published - 22. Jan 2024 |