Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Jan O. Nehlin*, Abbas Jafari, Michaela Tencerova, Moustapha Kassem

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.

Original languageEnglish
JournalBone
Volume123
Pages (from-to)265-273
ISSN8756-3282
DOIs
Publication statusPublished - 1. Jun 2019

Fingerprint

Stromal Cells
Adipocytes
Physiological Phenomena
Adiposity
Osteoblasts
Mesenchymal Stromal Cells
Homeostasis
Population

Keywords

  • Adiposity
  • Aging
  • Bone marrow stromal stem cells
  • Senescence
  • Signaling pathways

Cite this

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title = "Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells",
abstract = "Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.",
keywords = "Adiposity, Aging, Bone marrow stromal stem cells, Senescence, Signaling pathways",
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Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells. / Nehlin, Jan O.; Jafari, Abbas; Tencerova, Michaela; Kassem, Moustapha.

In: Bone, Vol. 123, 01.06.2019, p. 265-273.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

AU - Nehlin, Jan O.

AU - Jafari, Abbas

AU - Tencerova, Michaela

AU - Kassem, Moustapha

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.

AB - Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the “youthful” state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.

KW - Adiposity

KW - Aging

KW - Bone marrow stromal stem cells

KW - Senescence

KW - Signaling pathways

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DO - 10.1016/j.bone.2019.03.041

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JO - Bone

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SN - 8756-3282

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