Agents intervening against delirium in the intensive care unit trial: Protocol for a secondary Bayesian analysis

Nina Andersen-Ranberg*, Lone M. Poulsen, Anders Perner, Johanna Hästbacka, Matthew P.G. Morgan, Giuseppe Citerio, Marie Oxenbøll-Collet, Sven Olaf Weber, Anne Sofie Andreasen, Morten H. Bestle, Bülent Uslu, Helle B.S. Pedersen, Louise G. Nielsen, Kjeld Damgaard, Troels B. Jensen, Trine Sommer, Nilanjan Dey, Ole Mathiesen, Anders Granholm

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background: Delirium is highly prevalent in the intensive care unit (ICU) and is associated with high morbidity and mortality. The antipsychotic haloperidol is the most frequently used agent to treat delirium although this is not supported by solid evidence. The agents intervening against delirium in the intensive care unit (AID-ICU) trial investigates the effects of haloperidol versus placebo for the treatment of delirium in adult ICU patients. Methods: This protocol describes the secondary, pre-planned Bayesian analyses of the primary and secondary outcomes up to day 90 of the AID-ICU trial. We will use Bayesian linear regression models for all count outcomes and Bayesian logistic regression models for all dichotomous outcomes. We will adjust for stratification variables (site and delirium subtype) and use weakly informative priors supplemented with sensitivity analyses using sceptical priors. We will present results as absolute differences (mean differences and risk differences) and relative differences (ratios of means and relative risks). Posteriors will be summarised using median values as point estimates and percentile-based 95% credibility intervals. Probabilities of any benefit/harm, clinically important benefit/harm and clinically unimportant differences will be presented for all outcomes. Discussion: The results of this secondary, pre-planned Bayesian analysis will complement the primary frequentist analysis of the AID-ICU trial and facilitate a nuanced and probabilistic interpretation of the trial results.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume66
Issue number7
Pages (from-to)898-903
ISSN0001-5172
DOIs
Publication statusPublished - Aug 2022

Keywords

  • Bayesian statistics
  • Delirium
  • haloperidol
  • ICU
  • Delirium/drug therapy
  • Intensive Care Units
  • Humans
  • Bayes Theorem
  • Adult
  • Antipsychotic Agents/therapeutic use
  • Haloperidol/therapeutic use

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