Age at menarche and risk of multiple sclerosis: A prospective cohort study based on the Danish National Birth Cohort

Nete Munk Nielsen*, Maria Harpsøe, Jacob Simonsen, Egon Stenager, Melinda Magyari, Nils Koch-Henriksen, Jennifer L. Baker, Henrik Hjalgrim, Morten Frisch, Peter Bager

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Few studies have addressed the possible association between age at menarche and multiple sclerosis (MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95% confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13% (hazard ratio = 0.87, 95% confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.

Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume185
Issue number8
Pages (from-to)712-719
Number of pages8
ISSN0002-9262
DOIs
Publication statusPublished - 1. Jan 2017

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Menarche
Cohort Studies
Prospective Studies
Nonparametric Statistics
Confidence Intervals
Interviews
Proportional Hazards Models

Keywords

  • Cohort studies
  • Danish National Birth Cohort
  • Menarcheal age
  • Multiple sclerosis

Cite this

Nielsen, Nete Munk ; Harpsøe, Maria ; Simonsen, Jacob ; Stenager, Egon ; Magyari, Melinda ; Koch-Henriksen, Nils ; Baker, Jennifer L. ; Hjalgrim, Henrik ; Frisch, Morten ; Bager, Peter. / Age at menarche and risk of multiple sclerosis : A prospective cohort study based on the Danish National Birth Cohort. In: American Journal of Epidemiology. 2017 ; Vol. 185, No. 8. pp. 712-719.
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abstract = "Few studies have addressed the possible association between age at menarche and multiple sclerosis (MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95{\%} confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13{\%} (hazard ratio = 0.87, 95{\%} confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.",
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Nielsen, NM, Harpsøe, M, Simonsen, J, Stenager, E, Magyari, M, Koch-Henriksen, N, Baker, JL, Hjalgrim, H, Frisch, M & Bager, P 2017, 'Age at menarche and risk of multiple sclerosis: A prospective cohort study based on the Danish National Birth Cohort', American Journal of Epidemiology, vol. 185, no. 8, pp. 712-719. https://doi.org/10.1093/aje/kww160

Age at menarche and risk of multiple sclerosis : A prospective cohort study based on the Danish National Birth Cohort. / Nielsen, Nete Munk; Harpsøe, Maria; Simonsen, Jacob; Stenager, Egon; Magyari, Melinda; Koch-Henriksen, Nils; Baker, Jennifer L.; Hjalgrim, Henrik; Frisch, Morten; Bager, Peter.

In: American Journal of Epidemiology, Vol. 185, No. 8, 01.01.2017, p. 712-719.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Age at menarche and risk of multiple sclerosis

T2 - A prospective cohort study based on the Danish National Birth Cohort

AU - Nielsen, Nete Munk

AU - Harpsøe, Maria

AU - Simonsen, Jacob

AU - Stenager, Egon

AU - Magyari, Melinda

AU - Koch-Henriksen, Nils

AU - Baker, Jennifer L.

AU - Hjalgrim, Henrik

AU - Frisch, Morten

AU - Bager, Peter

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Few studies have addressed the possible association between age at menarche and multiple sclerosis (MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95% confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13% (hazard ratio = 0.87, 95% confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.

AB - Few studies have addressed the possible association between age at menarche and multiple sclerosis (MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95% confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13% (hazard ratio = 0.87, 95% confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.

KW - Cohort studies

KW - Danish National Birth Cohort

KW - Menarcheal age

KW - Multiple sclerosis

U2 - 10.1093/aje/kww160

DO - 10.1093/aje/kww160

M3 - Journal article

C2 - 28369233

AN - SCOPUS:85019741364

VL - 185

SP - 712

EP - 719

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 8

ER -