Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Jonas Mengel-From; Anne Marie Svane; Cino Pertoldi; Torsten Nygård Kristensen; Volker Loeschcke; Axel Skytthe; Kaare Christensen; Rune Lindahl-Jacobsen; Jacob Hjelmborg; Lene Christiansen

doi:10.1093/gerona/glz070

Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Jonas Mengel-From^*, Anne Marie Svane, Cino Pertoldi, Torsten Nygård Kristensen, Volker Loeschcke, Axel Skytthe, Kaare Christensen, Rune Lindahl-Jacobsen, Jacob Hjelmborg, Lene Christiansen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.

Original language	English
Journal	The Journals of Gerontology Series A
Volume	74
Issue number	12
Pages (from-to)	1853-1860
ISSN	1758-535X
DOIs	https://doi.org/10.1093/gerona/glz070
Publication status	Published - 13. Nov 2019

Bibliographical note

Keywords

Drosophila
Gender differences
Human ageing
Mitochondria
Human aging

Documents & Links

10.1093/gerona/glz070

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357451/pdf/glz070.pdf

Cite this

Mengel-From, J., Svane, A. M., Pertoldi, C., Kristensen, T. N., Loeschcke, V., Skytthe, A., Christensen, K., Lindahl-Jacobsen, R., Hjelmborg, J., & Christiansen, L. (2019). Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies. The Journals of Gerontology Series A, 74(12), 1853-1860. https://doi.org/10.1093/gerona/glz070

@article{391bcc03e77c416e820b248066a19245,

title = "Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies",

abstract = "Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.",

keywords = "Drosophila, Gender differences, Human ageing, Mitochondria, Human aging",

author = "Jonas Mengel-From and Svane, {Anne Marie} and Cino Pertoldi and Kristensen, {Torsten Nyg{\aa}rd} and Volker Loeschcke and Axel Skytthe and Kaare Christensen and Rune Lindahl-Jacobsen and Jacob Hjelmborg and Lene Christiansen",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2019",

month = nov,

day = "13",

doi = "10.1093/gerona/glz070",

language = "English",

volume = "74",

pages = "1853--1860",

journal = "The Journals of Gerontology Series A",

issn = "1758-535X",

publisher = "Oxford University Press",

number = "12",

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Mengel-From, J, Svane, AM, Pertoldi, C, Kristensen, TN, Loeschcke, V, Skytthe, A , Christensen, K , Lindahl-Jacobsen, R , Hjelmborg, J & Christiansen, L 2019, 'Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies', The Journals of Gerontology Series A, vol. 74, no. 12, pp. 1853-1860. https://doi.org/10.1093/gerona/glz070

TY - JOUR

T1 - Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

AU - Mengel-From, Jonas

AU - Svane, Anne Marie

AU - Pertoldi, Cino

AU - Kristensen, Torsten Nygård

AU - Loeschcke, Volker

AU - Skytthe, Axel

AU - Christensen, Kaare

AU - Lindahl-Jacobsen, Rune

AU - Hjelmborg, Jacob

AU - Christiansen, Lene

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.

AB - Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.

KW - Drosophila

KW - Gender differences

KW - Human ageing

KW - Mitochondria

KW - Human aging

U2 - 10.1093/gerona/glz070

DO - 10.1093/gerona/glz070

M3 - Journal article

C2 - 30874797

SN - 1758-535X

VL - 74

SP - 1853

EP - 1860

JO - The Journals of Gerontology Series A

JF - The Journals of Gerontology Series A

IS - 12

ER -

Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Abstract

Bibliographical note

Keywords

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