Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Jonas Mengel-From*, Anne Marie Svane, Cino Pertoldi, Torsten Nygård Kristensen, Volker Loeschcke, Axel Skytthe, Kaare Christensen, Rune Lindahl-Jacobsen, Jacob Hjelmborg, Lene Christiansen

*Corresponding author for this work

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Abstract

Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.

Original languageEnglish
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume74
Issue number12
Pages (from-to)1853-1860
ISSN1079-5006
DOIs
Publication statusPublished - 13. Nov 2019

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Fruit
Parents
Maternal Age
Health
Drosophila melanogaster
Sex Characteristics

Bibliographical note

© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

  • Drosophila
  • Gender differences
  • Human ageing
  • Mitochondria

Cite this

@article{391bcc03e77c416e820b248066a19245,
title = "Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies",
abstract = "Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.",
keywords = "Drosophila, Gender differences, Human ageing, Mitochondria",
author = "Jonas Mengel-From and Svane, {Anne Marie} and Cino Pertoldi and Kristensen, {Torsten Nyg{\aa}rd} and Volker Loeschcke and Axel Skytthe and Kaare Christensen and Rune Lindahl-Jacobsen and Jacob Hjelmborg and Lene Christiansen",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2019",
month = "11",
day = "13",
doi = "10.1093/gerona/glz070",
language = "English",
volume = "74",
pages = "1853--1860",
journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",
issn = "1079-5006",
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}

Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies. / Mengel-From, Jonas; Svane, Anne Marie; Pertoldi, Cino; Kristensen, Torsten Nygård; Loeschcke, Volker; Skytthe, Axel; Christensen, Kaare; Lindahl-Jacobsen, Rune; Hjelmborg, Jacob; Christiansen, Lene.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 74, No. 12, 13.11.2019, p. 1853-1860.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

AU - Mengel-From, Jonas

AU - Svane, Anne Marie

AU - Pertoldi, Cino

AU - Kristensen, Torsten Nygård

AU - Loeschcke, Volker

AU - Skytthe, Axel

AU - Christensen, Kaare

AU - Lindahl-Jacobsen, Rune

AU - Hjelmborg, Jacob

AU - Christiansen, Lene

N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.

AB - Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.

KW - Drosophila

KW - Gender differences

KW - Human ageing

KW - Mitochondria

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DO - 10.1093/gerona/glz070

M3 - Journal article

C2 - 30874797

VL - 74

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JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

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