Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children

Jostein Steene-Johannessen, Elin Kolle, Lars Bo Andersen, Sigmund A Anderssen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

PURPOSE: The purpose of this study was to describe levels of inflammation markers in Norwegian children and to examine the associations of adiposity, aerobic fitness and muscle fitness with markers of inflammation. METHODS: In 2005-2006, 1467 9-year-olds wererandomly selected from all regions in Norway. The participation rate was 89%. The inflammatory markers evaluated included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis factor- α (TNF-α), hepatocyte growth factor, resistin and interleukin-6. We assessed muscular strength by measuring explosive, isometric and endurance strength. Aerobic fitness was measured directly during a maximal cycle ergometer test. Adiposity was expressed as waist circumference (WC). RESULTS: The girls had significantly higher levels of CRP, leptin, adiponectin and resistin and lower levels of TNF-α compared to the boys. We observed a graded association of CRP and leptin levels across quintiles of WC, aerobic fitness and muscle fitness (P ≤0.001 for all participants). The regression analyses revealed that WC, aerobic fitness and muscle fitness were independently associated with the CRP (WC β= 0.158, P <0.001; aerobic fitness β= -0.190, P <0.001; muscle fitness β= -0.158, P <0.002) after adjustments for gender, age, Tanner pubertal stage and the other independent variables. The same pattern was observed for leptin levels (WC β= 0.406, P <0.001; aerobic fitness β= -0.298, P <0.001; muscle fitness β= -0.064, P <0.036). CONCLUSIONS: These data represent a reference material with respect to inflammatory markers. Our results show that adiposity, aerobic and muscle fitness were independently associated with the CRP and leptin levels.
Original languageEnglish
JournalMedicine and Science in Sports and Exercise
Volume45
Issue number4
Pages (from-to)714–721
Number of pages8
ISSN0195-9131
DOIs
Publication statusPublished - Apr 2013

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Adiposity
Leptin
Muscles
Resistin
Adiponectin
Tumor Necrosis Factor-alpha
Hepatocyte Growth Factor
Plasminogen Activator Inhibitor 1
Norway
Interleukin-6
Regression Analysis

Cite this

Steene-Johannessen, Jostein ; Kolle, Elin ; Andersen, Lars Bo ; Anderssen, Sigmund A. / Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children. In: Medicine and Science in Sports and Exercise. 2013 ; Vol. 45, No. 4. pp. 714–721.
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title = "Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children",
abstract = "PURPOSE: The purpose of this study was to describe levels of inflammation markers in Norwegian children and to examine the associations of adiposity, aerobic fitness and muscle fitness with markers of inflammation. METHODS: In 2005-2006, 1467 9-year-olds wererandomly selected from all regions in Norway. The participation rate was 89{\%}. The inflammatory markers evaluated included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis factor- α (TNF-α), hepatocyte growth factor, resistin and interleukin-6. We assessed muscular strength by measuring explosive, isometric and endurance strength. Aerobic fitness was measured directly during a maximal cycle ergometer test. Adiposity was expressed as waist circumference (WC). RESULTS: The girls had significantly higher levels of CRP, leptin, adiponectin and resistin and lower levels of TNF-α compared to the boys. We observed a graded association of CRP and leptin levels across quintiles of WC, aerobic fitness and muscle fitness (P ≤0.001 for all participants). The regression analyses revealed that WC, aerobic fitness and muscle fitness were independently associated with the CRP (WC β= 0.158, P <0.001; aerobic fitness β= -0.190, P <0.001; muscle fitness β= -0.158, P <0.002) after adjustments for gender, age, Tanner pubertal stage and the other independent variables. The same pattern was observed for leptin levels (WC β= 0.406, P <0.001; aerobic fitness β= -0.298, P <0.001; muscle fitness β= -0.064, P <0.036). CONCLUSIONS: These data represent a reference material with respect to inflammatory markers. Our results show that adiposity, aerobic and muscle fitness were independently associated with the CRP and leptin levels.",
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Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children. / Steene-Johannessen, Jostein; Kolle, Elin; Andersen, Lars Bo; Anderssen, Sigmund A.

In: Medicine and Science in Sports and Exercise, Vol. 45, No. 4, 04.2013, p. 714–721.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children

AU - Steene-Johannessen, Jostein

AU - Kolle, Elin

AU - Andersen, Lars Bo

AU - Anderssen, Sigmund A

N1 - Accepted for publication October 2012

PY - 2013/4

Y1 - 2013/4

N2 - PURPOSE: The purpose of this study was to describe levels of inflammation markers in Norwegian children and to examine the associations of adiposity, aerobic fitness and muscle fitness with markers of inflammation. METHODS: In 2005-2006, 1467 9-year-olds wererandomly selected from all regions in Norway. The participation rate was 89%. The inflammatory markers evaluated included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis factor- α (TNF-α), hepatocyte growth factor, resistin and interleukin-6. We assessed muscular strength by measuring explosive, isometric and endurance strength. Aerobic fitness was measured directly during a maximal cycle ergometer test. Adiposity was expressed as waist circumference (WC). RESULTS: The girls had significantly higher levels of CRP, leptin, adiponectin and resistin and lower levels of TNF-α compared to the boys. We observed a graded association of CRP and leptin levels across quintiles of WC, aerobic fitness and muscle fitness (P ≤0.001 for all participants). The regression analyses revealed that WC, aerobic fitness and muscle fitness were independently associated with the CRP (WC β= 0.158, P <0.001; aerobic fitness β= -0.190, P <0.001; muscle fitness β= -0.158, P <0.002) after adjustments for gender, age, Tanner pubertal stage and the other independent variables. The same pattern was observed for leptin levels (WC β= 0.406, P <0.001; aerobic fitness β= -0.298, P <0.001; muscle fitness β= -0.064, P <0.036). CONCLUSIONS: These data represent a reference material with respect to inflammatory markers. Our results show that adiposity, aerobic and muscle fitness were independently associated with the CRP and leptin levels.

AB - PURPOSE: The purpose of this study was to describe levels of inflammation markers in Norwegian children and to examine the associations of adiposity, aerobic fitness and muscle fitness with markers of inflammation. METHODS: In 2005-2006, 1467 9-year-olds wererandomly selected from all regions in Norway. The participation rate was 89%. The inflammatory markers evaluated included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis factor- α (TNF-α), hepatocyte growth factor, resistin and interleukin-6. We assessed muscular strength by measuring explosive, isometric and endurance strength. Aerobic fitness was measured directly during a maximal cycle ergometer test. Adiposity was expressed as waist circumference (WC). RESULTS: The girls had significantly higher levels of CRP, leptin, adiponectin and resistin and lower levels of TNF-α compared to the boys. We observed a graded association of CRP and leptin levels across quintiles of WC, aerobic fitness and muscle fitness (P ≤0.001 for all participants). The regression analyses revealed that WC, aerobic fitness and muscle fitness were independently associated with the CRP (WC β= 0.158, P <0.001; aerobic fitness β= -0.190, P <0.001; muscle fitness β= -0.158, P <0.002) after adjustments for gender, age, Tanner pubertal stage and the other independent variables. The same pattern was observed for leptin levels (WC β= 0.406, P <0.001; aerobic fitness β= -0.298, P <0.001; muscle fitness β= -0.064, P <0.036). CONCLUSIONS: These data represent a reference material with respect to inflammatory markers. Our results show that adiposity, aerobic and muscle fitness were independently associated with the CRP and leptin levels.

U2 - 10.1249/MSS.0b013e318279707a

DO - 10.1249/MSS.0b013e318279707a

M3 - Journal article

C2 - 23135365

VL - 45

SP - 714

EP - 721

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 4

ER -