Addressing challenges in future surveillance after surgery for early-stage cervical cancer

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: This study examines surveillance after early-stage cervical cancer surgery. Since the 1980s, the value of surveillance has been discussed continuously. The main question explored is whether surveillance serves the purpose of ensuring early diagnosis of recurrence.

MATERIALS AND METHODS: A retrospective cohort study included 389 women with cervical cancer who underwent surgery as the primary treatment modality at the Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark, from 1996 to 2011. We used data from patient files and the Danish National Pathology Data Bank. The cumulative risk was estimated by the Kaplan-Meier method and tested by the log-rank test.

RESULTS: Forty-three women (11%) had recurrence. Only 27% of the recurrent cases were diagnosed at a scheduled surveillance appointment, but they were often asymptomatic and seemed to have a better outcome after treatment compared with the recurrent cases diagnosed at self-referral.The 5-year survival was overall 91.3%, recurrence-free survival was 96%, and cancer-specific survival was 54%. The median recurrence-free interval was 23 months (range, 4-144) for the symptomatic patients and 14 months (range, 4-48) for the asymptomatic patients. The median survival after recurrence was 12 months (range, 2-132) for the symptomatic patients and 156 months (range, 40-180) for the asymptomatic patients.

CONCLUSIONS: At the moment, neither the value of surveillance nor the significance of self-referral related to survival after recurrence is known. In this study, those who are diagnosed with recurrence before symptom onset seem to fare better in terms of 5-year survival than those who are diagnosed after self-referral because of symptoms.

Original languageEnglish
JournalInternational Journal of Gynecological Cancer
Volume25
Issue number2
Pages (from-to)309-314
ISSN1048-891X
DOIs
Publication statusPublished - Feb 2015

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell
  • Denmark
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Monitoring, Physiologic
  • Neoplasm Staging
  • Recurrence
  • Retrospective Studies
  • Risk Assessment
  • Survival Analysis
  • Uterine Cervical Neoplasms
  • Watchful Waiting
  • Young Adult
  • Journal Article
  • Survival
  • Surveillance
  • Surgical treatment
  • Early-stage cervical cancer

Fingerprint

Dive into the research topics of 'Addressing challenges in future surveillance after surgery for early-stage cervical cancer'. Together they form a unique fingerprint.

Cite this