Acute presentation of craniopharyngioma in children and adults in a Danish national cohort

E H Nielsen, J O Jørgensen, Peter Bjørn Bjerre, M Andersen, Claus Andersen, Ulla Feldt-Rasmussen, Lars Poulsgaard, L O Kristensen, Jens Astrup, J Jørgensen, Peter Laurberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We aimed to study the occurrence of acute-onset symptoms at initial presentation in a national Danish cohort of patients with childhood- or adult-onset craniopharyngioma, and to investigate potential risk factors for acute presentation. Medical records of 189 consecutive patients (39 children, 150 adults) presenting with craniopharyngioma during the period 1985-2004 were reviewed, and data regarding initial symptoms, neuroimaging results, vision and pituitary function were systematically collected. Acute symptoms preceding hospital admission were noted. Subgroup analyses were based on age, gender and calendar year period. Potential risk factors for acute presentation were analysed through uni- and multivariate analyses. Acute symptoms were reported in 24 (13 %) patients. Acute visual symptoms, headache, nausea or vomiting were most frequently reported, and acute symptoms were more frequent among children (28 %) than among adults (9 %) (P 
Original languageEnglish
JournalPituitary
Volume16
Issue number4
Pages (from-to)528-535
Number of pages8
ISSN1386-341X
DOIs
Publication statusPublished - 2013

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