TY - JOUR
T1 - Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau
T2 - A beneficial effect of BCG vaccination for girls: Community based case-control study
AU - Stensballe, Lone Graff
AU - Nante, Ernesto
AU - Jensen, Inge Panum
AU - Kofoed, Poul Erik
AU - Poulsen, Anja
AU - Jensen, Henrik
AU - Newport, Melanie
AU - Marchant, Arnaud
AU - Aaby, Peter
N1 - Funding Information:
The studies of RSV received support from Danish Development Research Council, Danish Medical Research Council, WHO, and Novo Nordisk Foundation. Contributors: P.-E.K. and P.A. initiated the RSV studies. L.G.S., E.N., A.P., and P.-E.K. implemented the field studies. I.P.J. was responsible for testing of RSV antigen and antibodies. M.N., A.M., and P.A. developed the plan for the present study. L.G.S., H.J., and P.A. carried out the analyses. L.G.S. and P.A. wrote the first draft of the paper, and all authors contributed to the final version. Conflict of interest statement: None declared.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/1/26
Y1 - 2005/1/26
N2 - Among measles unvaccinated infants in Guinea-Bissau, we tested whether case infants with acute lower respiratory tract infection (ALRI), especially ALRI caused by respiratory syncytial virus (RSV), were more likely to be Bacille Calmette Guérin (BCG)-unvaccinated and to have no scar after BCG vaccination than were control infants without symptoms of ALRI. Three hundred and eighty-six case infants with ALRI were identified at a paediatric clinic (N = 84), a health centre (N = 82), and in a community morbidity surveillance system (N = 220). Control infants were matched on sex, age, and district and were also measles unvaccinated. In ALRI case infants, the adjusted OR of being BCG unvaccinated was 2.87 (1.31-6.32), 1.72 (0.48-6.19) in boys and 4.45 (1.48-13.4) in girls. Among BCG vaccinated ALRI case infants, the adjusted OR of having no BCG scar was 1.54 (0.86-2.75), 0.93 (0.45-1.91) in boys and 2.70 (1.21-6.02) in girls. In ALRI case infants with RSV infection, similar trends were observed. BCG vaccination may have a non-targeted protective effect against ALRI, the effect being most marked in girls.
AB - Among measles unvaccinated infants in Guinea-Bissau, we tested whether case infants with acute lower respiratory tract infection (ALRI), especially ALRI caused by respiratory syncytial virus (RSV), were more likely to be Bacille Calmette Guérin (BCG)-unvaccinated and to have no scar after BCG vaccination than were control infants without symptoms of ALRI. Three hundred and eighty-six case infants with ALRI were identified at a paediatric clinic (N = 84), a health centre (N = 82), and in a community morbidity surveillance system (N = 220). Control infants were matched on sex, age, and district and were also measles unvaccinated. In ALRI case infants, the adjusted OR of being BCG unvaccinated was 2.87 (1.31-6.32), 1.72 (0.48-6.19) in boys and 4.45 (1.48-13.4) in girls. Among BCG vaccinated ALRI case infants, the adjusted OR of having no BCG scar was 1.54 (0.86-2.75), 0.93 (0.45-1.91) in boys and 2.70 (1.21-6.02) in girls. In ALRI case infants with RSV infection, similar trends were observed. BCG vaccination may have a non-targeted protective effect against ALRI, the effect being most marked in girls.
KW - Acute lower respiratory tract infection (ALRI)
KW - Bacille Calmette Guérin vaccine (BCG)
KW - Respiratory syncytial virus (RSV)
UR - http://www.scopus.com/inward/record.url?scp=12344307260&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2004.09.006
DO - 10.1016/j.vaccine.2004.09.006
M3 - Journal article
C2 - 15652667
AN - SCOPUS:12344307260
VL - 23
SP - 1251
EP - 1257
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 10
ER -