Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Abdellatif El-Ahmadi*, Mujahed Sebastian Abassi, Hedvig Bille Andersson, Thomas Engstrøm, Peter Clemmensen, Steffen Helqvist, Erik Jørgensen, Henning Kelbæk, Frants Pedersen, Kari Saunamäki, Jacob Lønborg, Lene Holmvang

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

38 Downloads (Pure)

Abstract

Objectives The aim of the study was to investigate the incidence, risk factors and long-term prognosis of acute kidney injury (AKI) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (primary PCI). Method A large-scale, retrospective cohort study based on procedure-related variables, biochemical and mortality data collected between 2009 and 2014 at Rigshospitalet, Copenhagen, Denmark. AKI was defined as an increase in serum creatinine of 25% during the first 72 hours after the index procedure. Results A total of 4239 patients were treated with primary PCI of whom 4002 had available creatinine measurements allowing for assessment of AKI and inclusion in this study. The mean creatinine value upon presentation for all patients was 84 μmol/l (standard deviation (SD) ±40) and 97 μmol/l (SD ±53) at peak. AKI occurred in a total of 765 (19.1%) patients. Independent risk factors for the occurrence of AKI were age, time from symptom onset to procedure, peak value of troponin-T, female sex and the contrast volume to eGFR ratio. In a multivariable adjusted analysis AKI was independently associated with a higher mortality rate at 5 years follow-up (hazard ratio 1.39 [95%-confidence interval 1.03–1.88]). Conclusion In STEMI patients treated with primary PCI one in five experiences acute kidney injury, which was associated with a substantial increase in both short- and long-term mortality.

Original languageEnglish
Article numbere0226625
JournalPLOS ONE
Volume14
Issue number12
Number of pages11
ISSN1932-6203
DOIs
Publication statusPublished - 20. Dec 2019

Fingerprint Dive into the research topics of 'Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction'. Together they form a unique fingerprint.

Cite this