A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis

M. T. Bazelier, T. P. van Staa, B. M. J. Uitdehaag, C. Cooper, H. G. M. Leufkens, P. Vestergaard, J. Bentzen, F. de Vries

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Objective: To derive a simple score for estimating the long-term risk of osteoporotic and hip fracture in individual patients with MS. Methods: Using the UK General Practice Research Database linked to the National Hospital Registry (1997-2008), we identified patients with incident MS (n = 5,494). They were matched 1:6 by year of birth, sex, and practice with patients without MS (control subjects). Cox proportional hazards models were used to calculate the long-term risk of osteoporotic and hip fracture. We fitted the regression model with general and specific risk factors, and the final Cox model was converted into integer risk scores. Results: In comparison with the FRAX calculator, our risk score contains several new risk factors that have been linked with fracture, which include MS, use of antidepressants, use of anticonvulsants, history of falling, and history of fatigue. We estimated the 5- and 10-year risks of osteoporotic and hip fracture in relation to the risk score. The C-statistic was moderate (0.67) for the prediction of osteoporotic fracture and excellent (0.89) for the prediction of hip fracture. Conclusion: This is the first clinical risk score for fracture risk estimation involving MS as a risk factor. Neurology (R) 2012;79:922-928
    Original languageEnglish
    JournalNeurology
    Volume79
    Issue number9
    Pages (from-to)922-928
    Number of pages7
    ISSN0028-3878
    DOIs
    Publication statusPublished - 2012

    Cite this

    Bazelier, M. T., van Staa, T. P., Uitdehaag, B. M. J., Cooper, C., Leufkens, H. G. M., Vestergaard, P., ... de Vries, F. (2012). A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis. Neurology, 79(9), 922-928. https://doi.org/10.1212/WNL.0b013e318266faae
    Bazelier, M. T. ; van Staa, T. P. ; Uitdehaag, B. M. J. ; Cooper, C. ; Leufkens, H. G. M. ; Vestergaard, P. ; Bentzen, J. ; de Vries, F. / A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis. In: Neurology. 2012 ; Vol. 79, No. 9. pp. 922-928.
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    title = "A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis",
    abstract = "Objective: To derive a simple score for estimating the long-term risk of osteoporotic and hip fracture in individual patients with MS. Methods: Using the UK General Practice Research Database linked to the National Hospital Registry (1997-2008), we identified patients with incident MS (n = 5,494). They were matched 1:6 by year of birth, sex, and practice with patients without MS (control subjects). Cox proportional hazards models were used to calculate the long-term risk of osteoporotic and hip fracture. We fitted the regression model with general and specific risk factors, and the final Cox model was converted into integer risk scores. Results: In comparison with the FRAX calculator, our risk score contains several new risk factors that have been linked with fracture, which include MS, use of antidepressants, use of anticonvulsants, history of falling, and history of fatigue. We estimated the 5- and 10-year risks of osteoporotic and hip fracture in relation to the risk score. The C-statistic was moderate (0.67) for the prediction of osteoporotic fracture and excellent (0.89) for the prediction of hip fracture. Conclusion: This is the first clinical risk score for fracture risk estimation involving MS as a risk factor. Neurology (R) 2012;79:922-928",
    author = "Bazelier, {M. T.} and {van Staa}, {T. P.} and Uitdehaag, {B. M. J.} and C. Cooper and Leufkens, {H. G. M.} and P. Vestergaard and J. Bentzen and {de Vries}, F.",
    year = "2012",
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    language = "English",
    volume = "79",
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    Bazelier, MT, van Staa, TP, Uitdehaag, BMJ, Cooper, C, Leufkens, HGM, Vestergaard, P, Bentzen, J & de Vries, F 2012, 'A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis', Neurology, vol. 79, no. 9, pp. 922-928. https://doi.org/10.1212/WNL.0b013e318266faae

    A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis. / Bazelier, M. T.; van Staa, T. P.; Uitdehaag, B. M. J.; Cooper, C.; Leufkens, H. G. M.; Vestergaard, P.; Bentzen, J.; de Vries, F.

    In: Neurology, Vol. 79, No. 9, 2012, p. 922-928.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis

    AU - Bazelier, M. T.

    AU - van Staa, T. P.

    AU - Uitdehaag, B. M. J.

    AU - Cooper, C.

    AU - Leufkens, H. G. M.

    AU - Vestergaard, P.

    AU - Bentzen, J.

    AU - de Vries, F.

    PY - 2012

    Y1 - 2012

    N2 - Objective: To derive a simple score for estimating the long-term risk of osteoporotic and hip fracture in individual patients with MS. Methods: Using the UK General Practice Research Database linked to the National Hospital Registry (1997-2008), we identified patients with incident MS (n = 5,494). They were matched 1:6 by year of birth, sex, and practice with patients without MS (control subjects). Cox proportional hazards models were used to calculate the long-term risk of osteoporotic and hip fracture. We fitted the regression model with general and specific risk factors, and the final Cox model was converted into integer risk scores. Results: In comparison with the FRAX calculator, our risk score contains several new risk factors that have been linked with fracture, which include MS, use of antidepressants, use of anticonvulsants, history of falling, and history of fatigue. We estimated the 5- and 10-year risks of osteoporotic and hip fracture in relation to the risk score. The C-statistic was moderate (0.67) for the prediction of osteoporotic fracture and excellent (0.89) for the prediction of hip fracture. Conclusion: This is the first clinical risk score for fracture risk estimation involving MS as a risk factor. Neurology (R) 2012;79:922-928

    AB - Objective: To derive a simple score for estimating the long-term risk of osteoporotic and hip fracture in individual patients with MS. Methods: Using the UK General Practice Research Database linked to the National Hospital Registry (1997-2008), we identified patients with incident MS (n = 5,494). They were matched 1:6 by year of birth, sex, and practice with patients without MS (control subjects). Cox proportional hazards models were used to calculate the long-term risk of osteoporotic and hip fracture. We fitted the regression model with general and specific risk factors, and the final Cox model was converted into integer risk scores. Results: In comparison with the FRAX calculator, our risk score contains several new risk factors that have been linked with fracture, which include MS, use of antidepressants, use of anticonvulsants, history of falling, and history of fatigue. We estimated the 5- and 10-year risks of osteoporotic and hip fracture in relation to the risk score. The C-statistic was moderate (0.67) for the prediction of osteoporotic fracture and excellent (0.89) for the prediction of hip fracture. Conclusion: This is the first clinical risk score for fracture risk estimation involving MS as a risk factor. Neurology (R) 2012;79:922-928

    U2 - 10.1212/WNL.0b013e318266faae

    DO - 10.1212/WNL.0b013e318266faae

    M3 - Journal article

    VL - 79

    SP - 922

    EP - 928

    JO - Neurology

    JF - Neurology

    SN - 0028-3878

    IS - 9

    ER -

    Bazelier MT, van Staa TP, Uitdehaag BMJ, Cooper C, Leufkens HGM, Vestergaard P et al. A simple score for estimating the long-term risk of fracture in patients with multiple sclerosis. Neurology. 2012;79(9):922-928. https://doi.org/10.1212/WNL.0b013e318266faae