A short leucocyte telomere length is associated with development of insulin resistance

Simon Verhulst, Christine Dalgård, Carlos Labat, Jeremy D Kark, Masayuki Kimura, Kaare Christensen, Simon Toupance, Abraham Aviv, Kirsten O Kyvik, Athanase Benetos

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

AIMS/HYPOTHESIS: A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof.

METHODS: Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs.

RESULTS: Age at baseline examination was 37.4 ± 9.6 (mean ± SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL.

CONCLUSIONS/INTERPRETATION: These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.

Original languageEnglish
JournalDiabetologia
Volume59
Issue number6
Pages (from-to)1258-65
Number of pages8
ISSN0012-186X
DOIs
Publication statusPublished - Jun 2016

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Telomere
Insulin Resistance
Longitudinal Studies
Registries
Type 2 Diabetes Mellitus
Cohort Studies

Cite this

Verhulst, Simon ; Dalgård, Christine ; Labat, Carlos ; Kark, Jeremy D ; Kimura, Masayuki ; Christensen, Kaare ; Toupance, Simon ; Aviv, Abraham ; Kyvik, Kirsten O ; Benetos, Athanase. / A short leucocyte telomere length is associated with development of insulin resistance. In: Diabetologia. 2016 ; Vol. 59, No. 6. pp. 1258-65.
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title = "A short leucocyte telomere length is associated with development of insulin resistance",
abstract = "AIMS/HYPOTHESIS: A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof.METHODS: Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs.RESULTS: Age at baseline examination was 37.4 ± 9.6 (mean ± SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL.CONCLUSIONS/INTERPRETATION: These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.",
keywords = "Genetics/epidemiology (all), Human, Insulin sensitivity and resistance",
author = "Simon Verhulst and Christine Dalg{\aa}rd and Carlos Labat and Kark, {Jeremy D} and Masayuki Kimura and Kaare Christensen and Simon Toupance and Abraham Aviv and Kyvik, {Kirsten O} and Athanase Benetos",
year = "2016",
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pages = "1258--65",
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A short leucocyte telomere length is associated with development of insulin resistance. / Verhulst, Simon; Dalgård, Christine; Labat, Carlos; Kark, Jeremy D; Kimura, Masayuki; Christensen, Kaare; Toupance, Simon; Aviv, Abraham; Kyvik, Kirsten O; Benetos, Athanase.

In: Diabetologia, Vol. 59, No. 6, 06.2016, p. 1258-65.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A short leucocyte telomere length is associated with development of insulin resistance

AU - Verhulst, Simon

AU - Dalgård, Christine

AU - Labat, Carlos

AU - Kark, Jeremy D

AU - Kimura, Masayuki

AU - Christensen, Kaare

AU - Toupance, Simon

AU - Aviv, Abraham

AU - Kyvik, Kirsten O

AU - Benetos, Athanase

PY - 2016/6

Y1 - 2016/6

N2 - AIMS/HYPOTHESIS: A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof.METHODS: Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs.RESULTS: Age at baseline examination was 37.4 ± 9.6 (mean ± SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL.CONCLUSIONS/INTERPRETATION: These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.

AB - AIMS/HYPOTHESIS: A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof.METHODS: Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs.RESULTS: Age at baseline examination was 37.4 ± 9.6 (mean ± SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL.CONCLUSIONS/INTERPRETATION: These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.

KW - Genetics/epidemiology (all)

KW - Human

KW - Insulin sensitivity and resistance

U2 - 10.1007/s00125-016-3915-6

DO - 10.1007/s00125-016-3915-6

M3 - Journal article

C2 - 27020448

VL - 59

SP - 1258

EP - 1265

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 6

ER -