A Review of Clinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium

Manon Haché, Tom G. Hansen, Ruth Graham, Jamie W. Sinton, Phillip S. Adams, Carol Garber, Lynne Maxwell, Teeda Pinyavat*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review


Clinical researchers studying the long-term neurocognitive effects of anesthetic and sedative agents on children continue to struggle with identifying a phenotype for anesthetic neurotoxicity, the window of vulnerability, and the toxicity threshold in terms of concentration and duration. The Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) symposium at Columbia University included a moderated poster presentation session where 4 investigators presented their latest contributions to the landscape of clinical anesthetic neurotoxicity research. A lack of standardization in the design of clinical studies in terms of age at exposure, duration and type of exposure, and outcome measures assessed were highlighted by all the investigators. Suggestions for the future direction of clinical trials included the implementation of more consistent study parameters and the employment of standardized neurocognitive testing and imaging before and after exposure to general anesthesia. Presentations covered a broad range of topics including the valid translation of preclinical studies to human subjects, the quantification of real-world exposures to anesthetic and sedative medications, and possible alternatives to these exposures.

Original languageEnglish
JournalJournal of Neurosurgical Anesthesiology
Issue number1
Pages (from-to)166-169
Publication statusPublished - 1. Jan 2019



  • anesthesia
  • clinical research
  • neurodevelopment
  • neurotoxicity
  • outcomes
  • pediatric
  • surgery
  • Anesthesia/adverse effects
  • Anesthetics/adverse effects
  • Humans
  • Developmental Disabilities/chemically induced
  • Child, Preschool
  • Infant
  • Animals
  • Adolescent
  • Neurotoxicity Syndromes
  • Anesthesiology
  • Child
  • Infant, Newborn

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