A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

Tom E Andersen, Bente Finsen, Andre M Goffinet, Olaf-Georg Issinger, Brigitte Boldyreff

Research output: Contribution to journalJournal articleResearchpeer-review


In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20.
Original languageEnglish
JournalBrain Research. Molecular Brain Research
Issue number1-2
Pages (from-to)153-6
Number of pages3
Publication statusPublished - 2002


  • Animals
  • Base Sequence
  • Cell Adhesion Molecules, Neuronal
  • Cerebellum
  • DNA
  • Down-Regulation
  • Exons
  • Extracellular Matrix Proteins
  • Female
  • Gene Deletion
  • Male
  • Mice
  • Mice, Neurologic Mutants
  • Mutation
  • Nerve Tissue Proteins
  • Phenotype
  • RNA, Messenger
  • Serine Endopeptidases


Dive into the research topics of 'A reeler mutant mouse with a new, spontaneous mutation in the reelin gene'. Together they form a unique fingerprint.

Cite this