A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

Tom E Andersen; Bente Finsen; Andre M Goffinet; Olaf-Georg Issinger; Brigitte Boldyreff

doi:10.1016/s0169-328x(02)00389-3

A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

Tom E Andersen, Bente Finsen, Andre M Goffinet, Olaf-Georg Issinger, Brigitte Boldyreff

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20.

Original language	English
Journal	Molecular Brain Research
Volume	105
Issue number	1-2
Pages (from-to)	153-6
Number of pages	3
ISSN	0169-328X
DOIs	https://doi.org/10.1016/s0169-328x(02)00389-3
Publication status	Published - 2002

Keywords

Animals
Base Sequence
Cell Adhesion Molecules, Neuronal
Cerebellum
DNA
Down-Regulation
Exons
Extracellular Matrix Proteins
Female
Gene Deletion
Male
Mice
Mice, Neurologic Mutants
Mutation
Nerve Tissue Proteins
Phenotype
RNA, Messenger
Serine Endopeptidases

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10.1016/s0169-328x(02)00389-3

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title = "A reeler mutant mouse with a new, spontaneous mutation in the reelin gene",

abstract = "In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20.",

keywords = "Animals, Base Sequence, Cell Adhesion Molecules, Neuronal, Cerebellum, DNA, Down-Regulation, Exons, Extracellular Matrix Proteins, Female, Gene Deletion, Male, Mice, Mice, Neurologic Mutants, Mutation, Nerve Tissue Proteins, Phenotype, RNA, Messenger, Serine Endopeptidases",

author = "Andersen, {Tom E} and Bente Finsen and Goffinet, {Andre M} and Olaf-Georg Issinger and Brigitte Boldyreff",

year = "2002",

doi = "10.1016/s0169-328x(02)00389-3",

language = "English",

volume = "105",

pages = "153--6",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier",

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TY - JOUR

T1 - A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

AU - Andersen, Tom E

AU - Finsen, Bente

AU - Goffinet, Andre M

AU - Issinger, Olaf-Georg

AU - Boldyreff, Brigitte

PY - 2002

Y1 - 2002

N2 - In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20.

AB - In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20.

KW - Animals

KW - Base Sequence

KW - Cell Adhesion Molecules, Neuronal

KW - Cerebellum

KW - DNA

KW - Down-Regulation

KW - Exons

KW - Extracellular Matrix Proteins

KW - Female

KW - Gene Deletion

KW - Male

KW - Mice

KW - Mice, Neurologic Mutants

KW - Mutation

KW - Nerve Tissue Proteins

KW - Phenotype

KW - RNA, Messenger

KW - Serine Endopeptidases

U2 - 10.1016/s0169-328x(02)00389-3

DO - 10.1016/s0169-328x(02)00389-3

M3 - Journal article

C2 - 12399118

SN - 0169-328X

VL - 105

SP - 153

EP - 156

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

Abstract

Keywords

Documents & Links

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