A rare clinical presentation of Waldenström Macroglobulinemia mimicking lung cancer

Michael RT Laursen*, Shailesh Kolekar, Pradeesh Sivapalan, Paul F. Clementsen, Uffe Bodtger

*Corresponding author for this work

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Waldenström macroglobulinemia rarely presents as pulmonary symptoms, and even rarer as chylothorax. We present a patient who presented with bilateral pleural effusion and a 30 mm solid lesion in the lung. Biochemical analysis of the pleural fluid revealed chylothorax. The 18-fluorodeoxygenase positron emission tomography, bronchoscopy, endobronchial ultrasound, and cytological examination of the pleural fluid, showed no apparent cause of the chylothorax. The diagnostic breakthrough was made with flow cytometry of the pleural fluid, which revealed a small group of clonal B-cells. Biopsy from the parietal pleura and bone marrow led to the diagnosis Waldenström macroglobulinemia. This demonstrates that flow cytometry should be considered when routine diagnostics do not lead to a reach a specific diagnosis.

Original languageEnglish
Article number101580
JournalRespiratory Medicine Case Reports
Number of pages4
Publication statusPublished - Jan 2022

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  • Chylothorax
  • Flow cytometry
  • Waldenström macroglobulinemia


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