A rare cause of severe hepatomegaly with an improving outcome

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A previously healthy 43-year-old man presented with dyspnoea, 15 kg weight loss, severe hepatomegaly and alkaline phosphatase at 5400 U/L. Examinations seemed to suggest cirrhosis, but blood samples did not show any signs of underlying liver disease. Liver biopsy revealed amyloid light chain (AL) amyloidosis and bone marrow showed multiple myeloma (MM). The patient was treated with drugs of choice cyclophosphamide, bortezomib and dexamethasone. He responded well to the treatment and so far achieved partial response. Previously MM was associated with poor prognosis but due to improved treatment for AL the patient can achieve a progression-free period with good quality of life.

Original languageEnglish
JournalBMJ Case Reports
Volume2014
Number of pages3
ISSN1757-790X
DOIs
Publication statusPublished - 3. Apr 2014

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Hepatomegaly
Alkaline Phosphatase
Liver Diseases
Quality of Life
Liver
Pharmaceutical Preparations
Bortezomib

Cite this

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title = "A rare cause of severe hepatomegaly with an improving outcome",
abstract = "A previously healthy 43-year-old man presented with dyspnoea, 15 kg weight loss, severe hepatomegaly and alkaline phosphatase at 5400 U/L. Examinations seemed to suggest cirrhosis, but blood samples did not show any signs of underlying liver disease. Liver biopsy revealed amyloid light chain (AL) amyloidosis and bone marrow showed multiple myeloma (MM). The patient was treated with drugs of choice cyclophosphamide, bortezomib and dexamethasone. He responded well to the treatment and so far achieved partial response. Previously MM was associated with poor prognosis but due to improved treatment for AL the patient can achieve a progression-free period with good quality of life.",
author = "Godskesen, {Line Elberg} and Niels Abildgaard and Jens Kjeldsen and Aleksander Krag",
year = "2014",
month = "4",
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language = "English",
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A rare cause of severe hepatomegaly with an improving outcome. / Godskesen, Line Elberg; Abildgaard, Niels; Kjeldsen, Jens; Krag, Aleksander.

In: BMJ Case Reports, Vol. 2014, 03.04.2014.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A rare cause of severe hepatomegaly with an improving outcome

AU - Godskesen, Line Elberg

AU - Abildgaard, Niels

AU - Kjeldsen, Jens

AU - Krag, Aleksander

PY - 2014/4/3

Y1 - 2014/4/3

N2 - A previously healthy 43-year-old man presented with dyspnoea, 15 kg weight loss, severe hepatomegaly and alkaline phosphatase at 5400 U/L. Examinations seemed to suggest cirrhosis, but blood samples did not show any signs of underlying liver disease. Liver biopsy revealed amyloid light chain (AL) amyloidosis and bone marrow showed multiple myeloma (MM). The patient was treated with drugs of choice cyclophosphamide, bortezomib and dexamethasone. He responded well to the treatment and so far achieved partial response. Previously MM was associated with poor prognosis but due to improved treatment for AL the patient can achieve a progression-free period with good quality of life.

AB - A previously healthy 43-year-old man presented with dyspnoea, 15 kg weight loss, severe hepatomegaly and alkaline phosphatase at 5400 U/L. Examinations seemed to suggest cirrhosis, but blood samples did not show any signs of underlying liver disease. Liver biopsy revealed amyloid light chain (AL) amyloidosis and bone marrow showed multiple myeloma (MM). The patient was treated with drugs of choice cyclophosphamide, bortezomib and dexamethasone. He responded well to the treatment and so far achieved partial response. Previously MM was associated with poor prognosis but due to improved treatment for AL the patient can achieve a progression-free period with good quality of life.

U2 - 10.1136/bcr-2013-203360

DO - 10.1136/bcr-2013-203360

M3 - Journal article

C2 - 24700044

VL - 2014

JO - B M J Case Reports

JF - B M J Case Reports

SN - 1757-790X

ER -