A protein-centric view of in vitro biological model systems for schizophrenia

Abinaya Chandrasekaran, Pia Jensen, Fadumo A. Mohamed, Madeline Lancaster, Michael E. Benros, Martin R. Larsen, Kristine K. Freude*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Here we provide an overview of the state of the art of neuronal two-dimensional and three-dimensional model systems that can be combined with proteomics analyses to decipher specific brain pathology and detection of alternative entry points for drug development.

Original languageEnglish
JournalStem Cells
ISSN1066-5099
DOIs
Publication statusE-pub ahead of print - 25. Aug 2021

Bibliographical note

Publisher Copyright:
©2021 The Authors. Stem Cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2021

Keywords

  • experimental models
  • induced pluripotent stem cells
  • neural differentiation
  • tissue engineering

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