A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients

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Abstract

OBJECTIVE: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer.

RESULTS: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). A median of 19 (range 10-41; n = 434) lymph nodes were removed per patient. Pelvic lymph nodes with detectable FDG uptake were seen in two patients only, but the FDG-avid lesion on PET did not correspond with pathological findings in either patient. We found a significant increase in maximal standardized uptake value of the prostate of around 30% between early and late imaging. We found no correlation between clinical findings after radical prostatectomy and PET measurements.

Original languageEnglish
Article number871
JournalBMC Research Notes
Volume11
Number of pages4
ISSN1756-0500
DOIs
Publication statusPublished - 7. Dec 2018

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Fluorodeoxyglucose F18
Prostatic Neoplasms
Prospective Studies
Dissection
Image acquisition
Surgery
Lymph Nodes
Robots
Imaging techniques
Prostate

Keywords

  • Diagnostic imaging
  • Fluorodeoxyglucose
  • Positron emission tomography
  • Prostatic neoplasms

Cite this

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title = "A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients",
abstract = "OBJECTIVE: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer.RESULTS: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45{\%}). A median of 19 (range 10-41; n = 434) lymph nodes were removed per patient. Pelvic lymph nodes with detectable FDG uptake were seen in two patients only, but the FDG-avid lesion on PET did not correspond with pathological findings in either patient. We found a significant increase in maximal standardized uptake value of the prostate of around 30{\%} between early and late imaging. We found no correlation between clinical findings after radical prostatectomy and PET measurements.",
keywords = "Diagnostic imaging, Fluorodeoxyglucose, Positron emission tomography, Prostatic neoplasms",
author = "Mortensen, {Mike Allan} and Vilstrup, {Mie Holm} and Poulsen, {Mads Hvid} and Oke Gerke and H{\o}ilund-Carlsen, {Poul Flemming} and Lars Lund",
year = "2018",
month = "12",
day = "7",
doi = "10.1186/s13104-018-3985-2",
language = "English",
volume = "11",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "BioMed Central",

}

A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients. / Mortensen, Mike Allan; Vilstrup, Mie Holm; Poulsen, Mads Hvid; Gerke, Oke; Høilund-Carlsen, Poul Flemming; Lund, Lars.

In: BMC Research Notes, Vol. 11, 871, 07.12.2018.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients

AU - Mortensen, Mike Allan

AU - Vilstrup, Mie Holm

AU - Poulsen, Mads Hvid

AU - Gerke, Oke

AU - Høilund-Carlsen, Poul Flemming

AU - Lund, Lars

PY - 2018/12/7

Y1 - 2018/12/7

N2 - OBJECTIVE: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer.RESULTS: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). A median of 19 (range 10-41; n = 434) lymph nodes were removed per patient. Pelvic lymph nodes with detectable FDG uptake were seen in two patients only, but the FDG-avid lesion on PET did not correspond with pathological findings in either patient. We found a significant increase in maximal standardized uptake value of the prostate of around 30% between early and late imaging. We found no correlation between clinical findings after radical prostatectomy and PET measurements.

AB - OBJECTIVE: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer.RESULTS: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). A median of 19 (range 10-41; n = 434) lymph nodes were removed per patient. Pelvic lymph nodes with detectable FDG uptake were seen in two patients only, but the FDG-avid lesion on PET did not correspond with pathological findings in either patient. We found a significant increase in maximal standardized uptake value of the prostate of around 30% between early and late imaging. We found no correlation between clinical findings after radical prostatectomy and PET measurements.

KW - Diagnostic imaging

KW - Fluorodeoxyglucose

KW - Positron emission tomography

KW - Prostatic neoplasms

U2 - 10.1186/s13104-018-3985-2

DO - 10.1186/s13104-018-3985-2

M3 - Journal article

VL - 11

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

M1 - 871

ER -