A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

Keld-Erik Byg; Zsolt Illés; Tobias Sejbæk; Nina N. T. T. Nguyen; Sören Möller; Kate Lykke Lambertsen; Helle Hvilsted Nielsen; Torkell Juulsgaard Ellingsen

doi:10.1016/j.jneuroim.2022.577913

A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

Keld-Erik Byg^*, Zsolt Illés, Tobias Sejbæk, Nina N. T. T. Nguyen, Sören Möller, Kate Lykke Lambertsen, Helle Hvilsted Nielsen, Torkell Juulsgaard Ellingsen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

Original language	English
Article number	577913
Journal	Journal of Neuroimmunology
Volume	369
Number of pages	10
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2022.577913
Publication status	Published - 15. Aug 2022

Keywords

FAS
MRI
Neurosarcoidosis
SDMT
Treatment
mRS
Neuropsychological Tests
Central Nervous System Diseases/diagnostic imaging
Prospective Studies
Follow-Up Studies
Sarcoidosis
Humans

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10.1016/j.jneuroim.2022.577913Licence: CC BY

Open Access VersionFinal published version, 511 KBLicence: CC BY

1 Ph.D. thesis

Neurosarcoidosis: Inflammation, Damage, and Treatment response
Byg, K-E., 30. Sept 2022, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 123 p.
Research output: Thesis › Ph.D. thesis

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@article{4dc7e18023cc41388a31a6bd0f5a8cff,

title = "A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis",

abstract = "Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.",

keywords = "FAS, MRI, Neurosarcoidosis, SDMT, Treatment, mRS, Neuropsychological Tests, Central Nervous System Diseases/diagnostic imaging, Prospective Studies, Follow-Up Studies, Sarcoidosis, Humans",

author = "Keld-Erik Byg and Zsolt Ill{\'e}s and Tobias Sejb{\ae}k and Nguyen, {Nina N. T. T.} and S{\"o}ren M{\"o}ller and Lambertsen, {Kate Lykke} and Nielsen, {Helle Hvilsted} and Ellingsen, {Torkell Juulsgaard}",

year = "2022",

month = aug,

day = "15",

doi = "10.1016/j.jneuroim.2022.577913",

language = "English",

volume = "369",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

AU - Byg, Keld-Erik

AU - Illés, Zsolt

AU - Sejbæk, Tobias

AU - Nguyen, Nina N. T. T.

AU - Möller, Sören

AU - Lambertsen, Kate Lykke

AU - Nielsen, Helle Hvilsted

AU - Ellingsen, Torkell Juulsgaard

PY - 2022/8/15

Y1 - 2022/8/15

N2 - Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

AB - Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

KW - FAS

KW - MRI

KW - Neurosarcoidosis

KW - SDMT

KW - Treatment

KW - mRS

KW - Neuropsychological Tests

KW - Central Nervous System Diseases/diagnostic imaging

KW - Prospective Studies

KW - Follow-Up Studies

KW - Sarcoidosis

KW - Humans

U2 - 10.1016/j.jneuroim.2022.577913

DO - 10.1016/j.jneuroim.2022.577913

M3 - Journal article

C2 - 35717739

SN - 0165-5728

VL - 369

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577913

ER -

A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

Abstract

Keywords

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Related Research Output

Neurosarcoidosis: Inflammation, Damage, and Treatment response

Cite this