Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up. Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged. Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

Original languageEnglish
Article number577913
JournalJournal of Neuroimmunology
Number of pages10
Publication statusPublished - 15. Aug 2022


  • FAS
  • MRI
  • Neurosarcoidosis
  • SDMT
  • Treatment
  • mRS
  • Neuropsychological Tests
  • Central Nervous System Diseases/diagnostic imaging
  • Prospective Studies
  • Follow-Up Studies
  • Sarcoidosis
  • Humans


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