A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases

A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Vibeke Andersen, Uffe Holmskov, Signe Bek Sørensen, Mohamad Jawhara, Karina W Andersen, Anette Bygum, Lone Sylvester Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan Alexander Villadsen, Søren Geill Kjær, Jan Fallingborg, Seyed A G R Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens Frederik Dahlerup, Ole Haagen Nielsen & 18 others Robin Christensen, Anders Bo Bojesen, Grith Lykke Sorensen, Steffen Thiel, Nils J Færgeman, Ivan Brandslund, Allan Stensballe, Erik Berg Schmidt, Andre Franke, David Ellinghaus, Philip Rosenstiel, Jeroen Raes, Berit Heitmann, Mette Boye, Charlotte Lindgaard Nielsen, Lars Werner, Jens Kjeldsen, Torkell Ellingsen

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Abstract

Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

Original languageEnglish
Article number499
JournalNutrients
Volume9
Issue number5
Number of pages16
ISSN2072-6643
DOIs
Publication statusPublished - 2017

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Precision Medicine
tumor necrosis factors
lifestyle
medicine
inflammatory bowel disease
Tumor Necrosis Factor-alpha
psoriasis
therapeutics
rheumatoid arthritis
Crohn disease
dietary recommendations
Inflammatory Bowel Diseases
colitis
metabolomics
arthritis
proteomics
biopsy
Hidradenitis Suppurativa
urine
feces

Keywords

  • Journal Article

Cite this

Andersen, Vibeke ; Holmskov, Uffe ; Sørensen, Signe Bek ; Jawhara, Mohamad ; Andersen, Karina W ; Bygum, Anette ; Sylvester Hvid, Lone ; Grauslund, Jakob ; Wied, Jimmi ; Glerup, Henning ; Fredberg, Ulrich ; Villadsen, Jan Alexander ; Kjær, Søren Geill ; Fallingborg, Jan ; Moghadd, Seyed A G R ; Knudsen, Torben ; Brodersen, Jacob ; Frøjk, Jesper ; Dahlerup, Jens Frederik ; Nielsen, Ole Haagen ; Christensen, Robin ; Bojesen, Anders Bo ; Sorensen, Grith Lykke ; Thiel, Steffen ; Færgeman, Nils J ; Brandslund, Ivan ; Stensballe, Allan ; Schmidt, Erik Berg ; Franke, Andre ; Ellinghaus, David ; Rosenstiel, Philip ; Raes, Jeroen ; Heitmann, Berit ; Boye, Mette ; Lindgaard Nielsen, Charlotte ; Werner, Lars ; Kjeldsen, Jens ; Ellingsen, Torkell. / A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases : A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine. In: Nutrients. 2017 ; Vol. 9, No. 5.
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abstract = "Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.",
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A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases : A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine. / Andersen, Vibeke; Holmskov, Uffe; Sørensen, Signe Bek; Jawhara, Mohamad; Andersen, Karina W; Bygum, Anette; Sylvester Hvid, Lone ; Grauslund, Jakob; Wied, Jimmi; Glerup, Henning; Fredberg, Ulrich; Villadsen, Jan Alexander; Kjær, Søren Geill; Fallingborg, Jan; Moghadd, Seyed A G R; Knudsen, Torben; Brodersen, Jacob; Frøjk, Jesper; Dahlerup, Jens Frederik; Nielsen, Ole Haagen; Christensen, Robin; Bojesen, Anders Bo; Sorensen, Grith Lykke; Thiel, Steffen; Færgeman, Nils J; Brandslund, Ivan; Stensballe, Allan; Schmidt, Erik Berg; Franke, Andre; Ellinghaus, David; Rosenstiel, Philip; Raes, Jeroen; Heitmann, Berit; Boye, Mette; Lindgaard Nielsen, Charlotte; Werner, Lars; Kjeldsen, Jens; Ellingsen, Torkell.

In: Nutrients, Vol. 9, No. 5, 499, 2017.

Research output: Contribution to journalLetterResearchpeer-review

TY - JOUR

T1 - A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases

T2 - A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

AU - Andersen, Vibeke

AU - Holmskov, Uffe

AU - Sørensen, Signe Bek

AU - Jawhara, Mohamad

AU - Andersen, Karina W

AU - Bygum, Anette

AU - Sylvester Hvid, Lone

AU - Grauslund, Jakob

AU - Wied, Jimmi

AU - Glerup, Henning

AU - Fredberg, Ulrich

AU - Villadsen, Jan Alexander

AU - Kjær, Søren Geill

AU - Fallingborg, Jan

AU - Moghadd, Seyed A G R

AU - Knudsen, Torben

AU - Brodersen, Jacob

AU - Frøjk, Jesper

AU - Dahlerup, Jens Frederik

AU - Nielsen, Ole Haagen

AU - Christensen, Robin

AU - Bojesen, Anders Bo

AU - Sorensen, Grith Lykke

AU - Thiel, Steffen

AU - Færgeman, Nils J

AU - Brandslund, Ivan

AU - Stensballe, Allan

AU - Schmidt, Erik Berg

AU - Franke, Andre

AU - Ellinghaus, David

AU - Rosenstiel, Philip

AU - Raes, Jeroen

AU - Heitmann, Berit

AU - Boye, Mette

AU - Lindgaard Nielsen, Charlotte

AU - Werner, Lars

AU - Kjeldsen, Jens

AU - Ellingsen, Torkell

PY - 2017

Y1 - 2017

N2 - Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

AB - Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

KW - Journal Article

U2 - 10.3390/nu9050499

DO - 10.3390/nu9050499

M3 - Letter

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 5

M1 - 499

ER -