Abstract

BACKGROUND: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management.

OBJECTIVE: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON.

METHOD: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly.

RESULTS: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16-66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44-4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients.

CONCLUSION: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

Original languageEnglish
JournalMultiple sclerosis
Volume23
Issue number14
Pages (from-to)1893-1901
ISSN1352-4585
DOIs
Publication statusPublished - 5. Oct 2017

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Optic Neuritis
Prospective Studies
Population
Incidence
Neurologic Examination

Keywords

  • Journal Article

Cite this

Soelberg, K ; Jarius, S ; Skejoe, Hanne Pernille Bro ; Engberg, H ; Mehlsen, Jesper ; Nilsson, A C ; Madsen, J S ; Reindl, M ; Wildemann, B ; Grauslund, J ; Kyvik, K O ; Smith, T J ; Lillevang, S T ; Paul, Friedemann ; Weinshenker, B G ; Asgari, N. / A population-based prospective study of optic neuritis. In: Multiple sclerosis. 2017 ; Vol. 23, No. 14. pp. 1893-1901.
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title = "A population-based prospective study of optic neuritis",
abstract = "BACKGROUND: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management.OBJECTIVE: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON.METHOD: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly.RESULTS: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16-66); 44 (86{\%}) had a single episode of ON (four bilateral), while 7/51 (14{\%}) had recurrent ON. The overall age-specific incidence was 3.28 (2.44-4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients.CONCLUSION: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4{\%} of cases.",
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author = "K Soelberg and S Jarius and Skejoe, {Hanne Pernille Bro} and H Engberg and Jesper Mehlsen and Nilsson, {A C} and Madsen, {J S} and M Reindl and B Wildemann and J Grauslund and Kyvik, {K O} and Smith, {T J} and Lillevang, {S T} and Friedemann Paul and Weinshenker, {B G} and N Asgari",
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doi = "10.1177/1352458517734070",
language = "English",
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A population-based prospective study of optic neuritis. / Soelberg, K; Jarius, S; Skejoe, Hanne Pernille Bro; Engberg, H; Mehlsen, Jesper; Nilsson, A C; Madsen, J S; Reindl, M; Wildemann, B; Grauslund, J; Kyvik, K O; Smith, T J; Lillevang, S T; Paul, Friedemann; Weinshenker, B G; Asgari, N.

In: Multiple sclerosis, Vol. 23, No. 14, 05.10.2017, p. 1893-1901.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A population-based prospective study of optic neuritis

AU - Soelberg, K

AU - Jarius, S

AU - Skejoe, Hanne Pernille Bro

AU - Engberg, H

AU - Mehlsen, Jesper

AU - Nilsson, A C

AU - Madsen, J S

AU - Reindl, M

AU - Wildemann, B

AU - Grauslund, J

AU - Kyvik, K O

AU - Smith, T J

AU - Lillevang, S T

AU - Paul, Friedemann

AU - Weinshenker, B G

AU - Asgari, N

PY - 2017/10/5

Y1 - 2017/10/5

N2 - BACKGROUND: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management.OBJECTIVE: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON.METHOD: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly.RESULTS: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16-66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44-4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients.CONCLUSION: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

AB - BACKGROUND: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management.OBJECTIVE: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON.METHOD: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly.RESULTS: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16-66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44-4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients.CONCLUSION: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

KW - Journal Article

U2 - 10.1177/1352458517734070

DO - 10.1177/1352458517734070

M3 - Journal article

C2 - 28980518

VL - 23

SP - 1893

EP - 1901

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 14

ER -