A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary

V. Papp, A. Iljicsov, C. Rajda, M. Magyari, N. Koch-Henriksen, T. Petersen, G. Jakab, I. Deme, F. Nagy, P. Imre, Z. Lohner, K. Kovács, A. J. Birkás, Köves, G. Rum, Z. Nagy, L. Kerényi, L. Vécsei, K. Bencsik, Z. Jobbágy & 13 others P. Diószeghy, L. Horváth, G. Galántai, J. Kasza, G. Molnár, M. Simó, M. Sátori, C. Rózsa, P. Ács, T. Berki, G. Lovas, S. Komoly, Z. Illes*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background and purpose: The goal of this study was to determine the prevalence and incidence of neuromyelitis optica spectrum disorder (NMOSD) in Hungary based on the 2015 International Panel of NMO Diagnosis (IPND) criteria. Methods: A retrospective population-based cohort study was conducted of 6.4 million Hungarians (age ≥ 16 years) between 1 January 2006 and 31 December 2016. Possible NMOSD patients were selected via multistage re-evaluation from multiple sources. Crude and sex- and serostatus-specific prevalence (per 100 000 persons) and incidence rates (per 1 000 000 person-years) from 2006 to 2015 were estimated and age-adjusted rates were determined. Results: Of 2262 study candidates, 154 NMOSD patients (age ≥ 16 years) with onset until 31 December 2016 were identified based on 2015 IPND criteria. The prevalence analysis on 1 January 2016 included 123 NMOSD living cases, resulting in a prevalence of 1.91 [95% confidence interval (CI) 1.52–2.28] per 100 000 persons. The 101 incident cases emerging from the observed 76 394 288 person-years provided an incidence rate of 1.32 (95% CI 1.08–1.61) per 1 000 000 person-years. Age-adjusted prevalence was 1.87 (95% CI 1.56–2.23) per 100 000 persons and incidence was 1.20 (95% CI 0.98–1.46) per 1 000 000 person-years. Conclusions: In this first report of a large population-based epidemiological study from an Eastern European Caucasian population using robust case validation, a greater prevalence and incidence of NMOSD was found compared to previous large studies in Caucasian populations.

Original languageEnglish
JournalEuropean Journal of Neurology
ISSN1351-5101
DOIs
Publication statusE-pub ahead of print - 29. Aug 2019

Fingerprint

Neuromyelitis Optica
Hungary
Epidemiologic Studies
Population
Confidence Intervals
Incidence
Cohort Studies

Keywords

  • AQP4
  • incidence
  • IPND
  • neuromyelitis optica
  • population-based
  • prevalence

Cite this

Papp, V. ; Iljicsov, A. ; Rajda, C. ; Magyari, M. ; Koch-Henriksen, N. ; Petersen, T. ; Jakab, G. ; Deme, I. ; Nagy, F. ; Imre, P. ; Lohner, Z. ; Kovács, K. ; Birkás, A. J. ; Köves ; Rum, G. ; Nagy, Z. ; Kerényi, L. ; Vécsei, L. ; Bencsik, K. ; Jobbágy, Z. ; Diószeghy, P. ; Horváth, L. ; Galántai, G. ; Kasza, J. ; Molnár, G. ; Simó, M. ; Sátori, M. ; Rózsa, C. ; Ács, P. ; Berki, T. ; Lovas, G. ; Komoly, S. ; Illes, Z. / A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary. In: European Journal of Neurology. 2019.
@article{2a7272cca9be4d58a4124eca8f357455,
title = "A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary",
abstract = "Background and purpose: The goal of this study was to determine the prevalence and incidence of neuromyelitis optica spectrum disorder (NMOSD) in Hungary based on the 2015 International Panel of NMO Diagnosis (IPND) criteria. Methods: A retrospective population-based cohort study was conducted of 6.4 million Hungarians (age ≥ 16 years) between 1 January 2006 and 31 December 2016. Possible NMOSD patients were selected via multistage re-evaluation from multiple sources. Crude and sex- and serostatus-specific prevalence (per 100 000 persons) and incidence rates (per 1 000 000 person-years) from 2006 to 2015 were estimated and age-adjusted rates were determined. Results: Of 2262 study candidates, 154 NMOSD patients (age ≥ 16 years) with onset until 31 December 2016 were identified based on 2015 IPND criteria. The prevalence analysis on 1 January 2016 included 123 NMOSD living cases, resulting in a prevalence of 1.91 [95{\%} confidence interval (CI) 1.52–2.28] per 100 000 persons. The 101 incident cases emerging from the observed 76 394 288 person-years provided an incidence rate of 1.32 (95{\%} CI 1.08–1.61) per 1 000 000 person-years. Age-adjusted prevalence was 1.87 (95{\%} CI 1.56–2.23) per 100 000 persons and incidence was 1.20 (95{\%} CI 0.98–1.46) per 1 000 000 person-years. Conclusions: In this first report of a large population-based epidemiological study from an Eastern European Caucasian population using robust case validation, a greater prevalence and incidence of NMOSD was found compared to previous large studies in Caucasian populations.",
keywords = "AQP4, incidence, IPND, neuromyelitis optica, population-based, prevalence",
author = "V. Papp and A. Iljicsov and C. Rajda and M. Magyari and N. Koch-Henriksen and T. Petersen and G. Jakab and I. Deme and F. Nagy and P. Imre and Z. Lohner and K. Kov{\'a}cs and Birk{\'a}s, {A. J.} and K{\"o}ves and G. Rum and Z. Nagy and L. Ker{\'e}nyi and L. V{\'e}csei and K. Bencsik and Z. Jobb{\'a}gy and P. Di{\'o}szeghy and L. Horv{\'a}th and G. Gal{\'a}ntai and J. Kasza and G. Moln{\'a}r and M. Sim{\'o} and M. S{\'a}tori and C. R{\'o}zsa and P. {\'A}cs and T. Berki and G. Lovas and S. Komoly and Z. Illes",
year = "2019",
month = "8",
day = "29",
doi = "10.1111/ene.14079",
language = "English",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",

}

Papp, V, Iljicsov, A, Rajda, C, Magyari, M, Koch-Henriksen, N, Petersen, T, Jakab, G, Deme, I, Nagy, F, Imre, P, Lohner, Z, Kovács, K, Birkás, AJ, Köves, Rum, G, Nagy, Z, Kerényi, L, Vécsei, L, Bencsik, K, Jobbágy, Z, Diószeghy, P, Horváth, L, Galántai, G, Kasza, J, Molnár, G, Simó, M, Sátori, M, Rózsa, C, Ács, P, Berki, T, Lovas, G, Komoly, S & Illes, Z 2019, 'A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary', European Journal of Neurology. https://doi.org/10.1111/ene.14079

A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary. / Papp, V.; Iljicsov, A.; Rajda, C.; Magyari, M.; Koch-Henriksen, N.; Petersen, T.; Jakab, G.; Deme, I.; Nagy, F.; Imre, P.; Lohner, Z.; Kovács, K.; Birkás, A. J.; Köves; Rum, G.; Nagy, Z.; Kerényi, L.; Vécsei, L.; Bencsik, K.; Jobbágy, Z.; Diószeghy, P.; Horváth, L.; Galántai, G.; Kasza, J.; Molnár, G.; Simó, M.; Sátori, M.; Rózsa, C.; Ács, P.; Berki, T.; Lovas, G.; Komoly, S.; Illes, Z.

In: European Journal of Neurology, 29.08.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary

AU - Papp, V.

AU - Iljicsov, A.

AU - Rajda, C.

AU - Magyari, M.

AU - Koch-Henriksen, N.

AU - Petersen, T.

AU - Jakab, G.

AU - Deme, I.

AU - Nagy, F.

AU - Imre, P.

AU - Lohner, Z.

AU - Kovács, K.

AU - Birkás, A. J.

AU - Köves,

AU - Rum, G.

AU - Nagy, Z.

AU - Kerényi, L.

AU - Vécsei, L.

AU - Bencsik, K.

AU - Jobbágy, Z.

AU - Diószeghy, P.

AU - Horváth, L.

AU - Galántai, G.

AU - Kasza, J.

AU - Molnár, G.

AU - Simó, M.

AU - Sátori, M.

AU - Rózsa, C.

AU - Ács, P.

AU - Berki, T.

AU - Lovas, G.

AU - Komoly, S.

AU - Illes, Z.

PY - 2019/8/29

Y1 - 2019/8/29

N2 - Background and purpose: The goal of this study was to determine the prevalence and incidence of neuromyelitis optica spectrum disorder (NMOSD) in Hungary based on the 2015 International Panel of NMO Diagnosis (IPND) criteria. Methods: A retrospective population-based cohort study was conducted of 6.4 million Hungarians (age ≥ 16 years) between 1 January 2006 and 31 December 2016. Possible NMOSD patients were selected via multistage re-evaluation from multiple sources. Crude and sex- and serostatus-specific prevalence (per 100 000 persons) and incidence rates (per 1 000 000 person-years) from 2006 to 2015 were estimated and age-adjusted rates were determined. Results: Of 2262 study candidates, 154 NMOSD patients (age ≥ 16 years) with onset until 31 December 2016 were identified based on 2015 IPND criteria. The prevalence analysis on 1 January 2016 included 123 NMOSD living cases, resulting in a prevalence of 1.91 [95% confidence interval (CI) 1.52–2.28] per 100 000 persons. The 101 incident cases emerging from the observed 76 394 288 person-years provided an incidence rate of 1.32 (95% CI 1.08–1.61) per 1 000 000 person-years. Age-adjusted prevalence was 1.87 (95% CI 1.56–2.23) per 100 000 persons and incidence was 1.20 (95% CI 0.98–1.46) per 1 000 000 person-years. Conclusions: In this first report of a large population-based epidemiological study from an Eastern European Caucasian population using robust case validation, a greater prevalence and incidence of NMOSD was found compared to previous large studies in Caucasian populations.

AB - Background and purpose: The goal of this study was to determine the prevalence and incidence of neuromyelitis optica spectrum disorder (NMOSD) in Hungary based on the 2015 International Panel of NMO Diagnosis (IPND) criteria. Methods: A retrospective population-based cohort study was conducted of 6.4 million Hungarians (age ≥ 16 years) between 1 January 2006 and 31 December 2016. Possible NMOSD patients were selected via multistage re-evaluation from multiple sources. Crude and sex- and serostatus-specific prevalence (per 100 000 persons) and incidence rates (per 1 000 000 person-years) from 2006 to 2015 were estimated and age-adjusted rates were determined. Results: Of 2262 study candidates, 154 NMOSD patients (age ≥ 16 years) with onset until 31 December 2016 were identified based on 2015 IPND criteria. The prevalence analysis on 1 January 2016 included 123 NMOSD living cases, resulting in a prevalence of 1.91 [95% confidence interval (CI) 1.52–2.28] per 100 000 persons. The 101 incident cases emerging from the observed 76 394 288 person-years provided an incidence rate of 1.32 (95% CI 1.08–1.61) per 1 000 000 person-years. Age-adjusted prevalence was 1.87 (95% CI 1.56–2.23) per 100 000 persons and incidence was 1.20 (95% CI 0.98–1.46) per 1 000 000 person-years. Conclusions: In this first report of a large population-based epidemiological study from an Eastern European Caucasian population using robust case validation, a greater prevalence and incidence of NMOSD was found compared to previous large studies in Caucasian populations.

KW - AQP4

KW - incidence

KW - IPND

KW - neuromyelitis optica

KW - population-based

KW - prevalence

U2 - 10.1111/ene.14079

DO - 10.1111/ene.14079

M3 - Journal article

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

ER -