A perspective on muscle phenotyping in musculoskeletal research

Ines Foessl; Cheryl L. Ackert-Bicknell; Erika Kague; Faidra Laskou; Franz Jakob; David Karasik; Barbara Obermayer-Pietsch; Co-authors; Neha Sharma; Kent Søe

doi:10.1016/j.tem.2024.01.004

A perspective on muscle phenotyping in musculoskeletal research

Ines Foessl^*, Cheryl L. Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Co-authors, Neha Sharma (Member of author group), Kent Søe (Member of author group)

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	35
Issue number	6
Pages (from-to)	478-489
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2024.01.004
Publication status	Published - Jun 2024

Keywords

animal models
muscle
musculoskeletal phenotyping
sarcopenia
Humans
Osteoporosis/metabolism
Muscle, Skeletal/metabolism
Zebrafish
Sarcopenia/metabolism
Phenotype
Animals
Musculoskeletal Diseases/physiopathology
Mice

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10.1016/j.tem.2024.01.004Licence: CC BY

Open Access VersionFinal published version, 1.62 MBLicence: CC BY

Cite this

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title = "A perspective on muscle phenotyping in musculoskeletal research",

abstract = "Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term {\textquoteleft}osteosarcopenia{\textquoteright}, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action {\textquoteleft}Genomics of MusculoSkeletal traits Translational Network{\textquoteright} (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.",

keywords = "animal models, muscle, musculoskeletal phenotyping, sarcopenia, Humans, Osteoporosis/metabolism, Muscle, Skeletal/metabolism, Zebrafish, Sarcopenia/metabolism, Phenotype, Animals, Musculoskeletal Diseases/physiopathology, Mice",

author = "Ines Foessl and Ackert-Bicknell, {Cheryl L.} and Erika Kague and Faidra Laskou and Franz Jakob and David Karasik and Barbara Obermayer-Pietsch and Co-authors and Neha Sharma and Kent S{\o}e",

year = "2024",

month = jun,

doi = "10.1016/j.tem.2024.01.004",

language = "English",

volume = "35",

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journal = "Trends in Endocrinology and Metabolism",

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T1 - A perspective on muscle phenotyping in musculoskeletal research

AU - Foessl, Ines

AU - Ackert-Bicknell, Cheryl L.

AU - Kague, Erika

AU - Laskou, Faidra

AU - Jakob, Franz

AU - Karasik, David

AU - Obermayer-Pietsch, Barbara

AU - Co-authors

A2 - Sharma, Neha

A2 - Søe, Kent

PY - 2024/6

Y1 - 2024/6

N2 - Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

AB - Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

KW - animal models

KW - muscle

KW - musculoskeletal phenotyping

KW - sarcopenia

KW - Humans

KW - Osteoporosis/metabolism

KW - Muscle, Skeletal/metabolism

KW - Zebrafish

KW - Sarcopenia/metabolism

KW - Phenotype

KW - Animals

KW - Musculoskeletal Diseases/physiopathology

KW - Mice

U2 - 10.1016/j.tem.2024.01.004

DO - 10.1016/j.tem.2024.01.004

M3 - Journal article

C2 - 38553405

SN - 1043-2760

VL - 35

SP - 478

EP - 489

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 6

ER -

A perspective on muscle phenotyping in musculoskeletal research

Abstract

Keywords

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