A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection

Kristian Stærk, Rasmus Birkholm Grønnemose, Yaseelan Palarasah, Hans Jørn Kolmos, Lars Lund, Martin Alm, Peter Thomsen, Thomas Emil Andersen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background: Catheter-associated urinary tract infection (CAUTI) is a frequent community-acquired infection and the most common nosocomial infection. Here, we developed a novel antimicrobial catheter concept that utilizes a silicone-based interpenetrating polymer network (IPN) as balloon material to facilitate a topical slow-release prophylaxis of antibacterial agents across the balloon to the urinary bladder. Methods: The balloon material was achieved by modifying low shore hardness silicone tubes with a hydrogel interpenetrating polymer in supercritical CO2 using the sequential method. Release properties and antibacterial efficacy of the IPN balloon treatment concept was investigated in vitro and in a porcine CAUTI model developed for the study. In the latter, Bactiguard Infection Protection (BIP) Foley catheters were also assessed to enable benchmark with the traditional antimicrobial coating principle. Results: Uropathogenic Escherichia coli was undetectable in urinary bladders and on retrieved catheters in the IPN treatment group as compared to control that revealed significant bacteriuria (>105 colony forming units/ml) as well as catheter-associated biofilm. The BIP catheters failed to prevent E. coli colonization of the bladder but significantly reduced catheter biofilm formation compared to the control. Conclusion: The IPN-catheter concept provides a novel, promising delivery route for local treatment in the urinary tract.

Original languageEnglish
Article number685698
JournalFrontiers in Microbiology
Volume12
ISSN1664-302X
DOIs
Publication statusPublished - 25. Jun 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Stærk, Grønnemose, Palarasah, Kolmos, Lund, Alm, Thomsen and Andersen.

Keywords

  • CAUTI
  • drug release
  • interpenetrating polymer network
  • large animal model
  • urinary catheter
  • uropathogenic Escherichia coli

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