A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations

Aksel Karl Georg Jensen, Henrik Ravn, S. Sorup, Per Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload. Copyright (C) 2016 John Wiley & Sons, Ltd.
Original languageEnglish
JournalStatistics in Medicine
Volume35
Issue number27
Pages (from-to)5051-5069
ISSN0277-6715
DOIs
Publication statusPublished - 30. Nov 2016

Bibliographical note

ISI Document Delivery No.: EB4NA Times Cited: 0 Cited Reference Count: 35 Jensen, Aksel K. G. Ravn, Henrik Sorup, Signe Andersen, Per Danish National Research Foundation (DNRF) supports the Research Center for Vitamins and Vaccines [DNRF108] The Danish National Research Foundation (DNRF) supports the Research Center for Vitamins and Vaccines (DNRF108). 0 1 Wiley-blackwell Hoboken 1097-0258

Keywords

  • marginal structural model recurrent events continuously updated weights non-specific effects of vaccination multi-state model randomized-trial multistate models causal inference measles-vaccine epidemiology admissions zidovudine birth bcg age Mathematical & Computational Biology Public, Environmental & Occupational Health Medical Informatics Research & Experimental Medicine Mathematics
  • multi-state model
  • continuously updated weights
  • non-specific effects of vaccination
  • recurrent events
  • marginal structural model
  • Humans
  • Hospitalization
  • Models, Statistical
  • Vaccines
  • Immunity, Heterologous
  • Denmark
  • Registries
  • Child
  • Cohort Studies

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