A genome-wide association study of cognitive function in Chinese adult twins

Chunsheng Xu, Dongfeng Zhang, Yili Wu, Xiaocao Tian, Zengchang Pang, Shuxia Li, Qihua Tan

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions. Regression-based mixed-effect kinship model of GWAS was conducted to test the SNPs. Gene-based analysis was performed on VEGAS2. The statistically significant genes were then subject to gene set enrichment analysis to further identify the specific biological pathways associated with cognitive function. No SNPs reached genome-wide significance although there were 13 SNPs of suggestive significance (P < 10(-5)). Gene-based analysis found 823 significant genes topped by TNRC18P1 (P = 1.00 × 10(-6)), FGFR1OP2 (P = 6.00 × 10(-6)), and AKR1D1 (P = 2.30 × 10(-5)). Enrichment analysis identified 46 biological pathways, mainly involving in signaling transmission, metabolic process and Alzheimer's disease. Analysis of SNPs involved in the regulatory motif detected cell-type specific enhancers involving aorta and colon smooth muscle both have been reported to implicate in cognition. We conclude that genetic variations are significantly involved in functional genes, biological pathways and the regulatory domain that mediate cognitive performances.

Original languageEnglish
JournalBiogerontology
Volume18
Issue number5
Pages (from-to)811–819
ISSN1389-5729
DOIs
Publication statusPublished - 2017

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Genome-Wide Association Study
Cognition
Single Nucleotide Polymorphism
Dizygotic Twins
Metabolic Diseases
Smooth Muscle
Alzheimer Disease
Colon
Population

Keywords

  • Journal Article

Cite this

Xu, Chunsheng ; Zhang, Dongfeng ; Wu, Yili ; Tian, Xiaocao ; Pang, Zengchang ; Li, Shuxia ; Tan, Qihua. / A genome-wide association study of cognitive function in Chinese adult twins. In: Biogerontology. 2017 ; Vol. 18, No. 5. pp. 811–819.
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abstract = "Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions. Regression-based mixed-effect kinship model of GWAS was conducted to test the SNPs. Gene-based analysis was performed on VEGAS2. The statistically significant genes were then subject to gene set enrichment analysis to further identify the specific biological pathways associated with cognitive function. No SNPs reached genome-wide significance although there were 13 SNPs of suggestive significance (P < 10(-5)). Gene-based analysis found 823 significant genes topped by TNRC18P1 (P = 1.00 × 10(-6)), FGFR1OP2 (P = 6.00 × 10(-6)), and AKR1D1 (P = 2.30 × 10(-5)). Enrichment analysis identified 46 biological pathways, mainly involving in signaling transmission, metabolic process and Alzheimer's disease. Analysis of SNPs involved in the regulatory motif detected cell-type specific enhancers involving aorta and colon smooth muscle both have been reported to implicate in cognition. We conclude that genetic variations are significantly involved in functional genes, biological pathways and the regulatory domain that mediate cognitive performances.",
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A genome-wide association study of cognitive function in Chinese adult twins. / Xu, Chunsheng; Zhang, Dongfeng; Wu, Yili; Tian, Xiaocao; Pang, Zengchang; Li, Shuxia; Tan, Qihua.

In: Biogerontology, Vol. 18, No. 5, 2017, p. 811–819.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A genome-wide association study of cognitive function in Chinese adult twins

AU - Xu, Chunsheng

AU - Zhang, Dongfeng

AU - Wu, Yili

AU - Tian, Xiaocao

AU - Pang, Zengchang

AU - Li, Shuxia

AU - Tan, Qihua

PY - 2017

Y1 - 2017

N2 - Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions. Regression-based mixed-effect kinship model of GWAS was conducted to test the SNPs. Gene-based analysis was performed on VEGAS2. The statistically significant genes were then subject to gene set enrichment analysis to further identify the specific biological pathways associated with cognitive function. No SNPs reached genome-wide significance although there were 13 SNPs of suggestive significance (P < 10(-5)). Gene-based analysis found 823 significant genes topped by TNRC18P1 (P = 1.00 × 10(-6)), FGFR1OP2 (P = 6.00 × 10(-6)), and AKR1D1 (P = 2.30 × 10(-5)). Enrichment analysis identified 46 biological pathways, mainly involving in signaling transmission, metabolic process and Alzheimer's disease. Analysis of SNPs involved in the regulatory motif detected cell-type specific enhancers involving aorta and colon smooth muscle both have been reported to implicate in cognition. We conclude that genetic variations are significantly involved in functional genes, biological pathways and the regulatory domain that mediate cognitive performances.

AB - Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions. Regression-based mixed-effect kinship model of GWAS was conducted to test the SNPs. Gene-based analysis was performed on VEGAS2. The statistically significant genes were then subject to gene set enrichment analysis to further identify the specific biological pathways associated with cognitive function. No SNPs reached genome-wide significance although there were 13 SNPs of suggestive significance (P < 10(-5)). Gene-based analysis found 823 significant genes topped by TNRC18P1 (P = 1.00 × 10(-6)), FGFR1OP2 (P = 6.00 × 10(-6)), and AKR1D1 (P = 2.30 × 10(-5)). Enrichment analysis identified 46 biological pathways, mainly involving in signaling transmission, metabolic process and Alzheimer's disease. Analysis of SNPs involved in the regulatory motif detected cell-type specific enhancers involving aorta and colon smooth muscle both have been reported to implicate in cognition. We conclude that genetic variations are significantly involved in functional genes, biological pathways and the regulatory domain that mediate cognitive performances.

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