A comparison of pediatric and adult neuromyelitis optica spectrum disorders: A review of clinical manifestation, diagnosis, and treatment

Seyed Mohammad Baghbanian*, Nasrin Asgari, Mohammad Ali Sahraian, Abdorreza Naser Moghadasi

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

184 Downloads (Pure)

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). Serum immunoglobulin G autoantibodies (NMO-IgG) are identified in the majority of NMOSD patients. The Pediatric form presents before 18 years. Based on the similarity of clinical, neuroimaging, and laboratory characteristics of pediatric NMOSD to those of the adult form, the international panel suggested that adult criteria of NMOSD also are appropriate in pediatric patients. However, the proposed criteria need validation in pediatric patients. This strategy poses challenges to the study design in clinical trials in pediatric NMOSD patients.

Original languageEnglish
JournalJournal of the Neurological Sciences
Volume388
Pages (from-to)222-231
ISSN0022-510X
DOIs
Publication statusPublished - 15. May 2018

    Fingerprint

Bibliographical note

Copyright © 2018. Published by Elsevier B.V.

Keywords

  • Neuromyelitis optica spectrum disorders - pediatric

Cite this