A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids

Liang Xu; Steven W Plouffe; Jenny Chong; Jesper Wengel; Dong Wang

doi:10.1002/anie.201307661

A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids

Liang Xu, Steven W Plouffe, Jenny Chong, Jesper Wengel, Dong Wang

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.

Original language	English
Journal	Angewandte Chemie International Edition
Volume	52
Issue number	47
Pages (from-to)	12341-12345
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201307661
Publication status	Published - 2013

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10.1002/anie.201307661

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title = "A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids",

abstract = "Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.",

author = "Liang Xu and Plouffe, {Steven W} and Jenny Chong and Jesper Wengel and Dong Wang",

note = "Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2013",

doi = "10.1002/anie.201307661",

language = "English",

volume = "52",

pages = "12341--12345",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "Wiley-VCH",

number = "47",

}

A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids. / Xu, Liang; Plouffe, Steven W; Chong, Jenny; Wengel, Jesper; Wang, Dong.

In: Angewandte Chemie International Edition, Vol. 52, No. 47, 2013, p. 12341-12345.

Research output: Contribution to journal › Journal article › Research › peer-review

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T1 - A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids

AU - Xu, Liang

AU - Plouffe, Steven W

AU - Chong, Jenny

AU - Wengel, Jesper

AU - Wang, Dong

PY - 2013

Y1 - 2013

N2 - Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.

AB - Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.

U2 - 10.1002/anie.201307661

DO - 10.1002/anie.201307661

M3 - Journal article

C2 - 24167045

VL - 52

SP - 12341

EP - 12345

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

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