A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids

Liang Xu, Steven W Plouffe, Jenny Chong, Jesper Wengel, Dong Wang

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.
Original languageEnglish
JournalAngewandte Chemie International Edition
Volume52
Issue number47
Pages (from-to)12341-12345
ISSN1433-7851
DOIs
Publication statusPublished - 2013

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