A 3-year follow-up after anterior colporrhaphy compared with collagen-coated transvaginal mesh for anterior vaginal wall prolapse: a randomised controlled trial

Martin Rudnicki, E Laurikainen, R Pogosean, I Kinne, U Jakobsson, P Teleman

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective To compare the 1-year (previously published) and 3-year objective and subjective cure rates, and complications, related to the use of a collagen-coated transvaginal mesh for anterior vaginal wall prolapse against a conventional anterior repair. Design Randomised controlled study. Setting Six departments of obstetrics and gynaecology in Norway, Sweden, Finland, and Denmark. Population A total of 138 women, of 55 years of age or older, admitted for stage ≥2 anterior vaginal wall prolapse. Methods The women scheduled for primary anterior vaginal wall prolapse surgery were randomised between conventional anterior colporrhaphy and surgery with a collagen-coated prolene mesh. All patients were evaluated using the Pelvic Organ Prolapse Quantification (POP-Q) assessment before and after surgery. Symptoms related to pelvic organ prolapse were evaluated using the Pelvic Floor Impact Questionnaire (PFIQ-7) and the Pelvic Floor Distress Inventory (PFDI-20). Main outcome measures Objective cure, defined as POP-Q stage <2 prolapse at the 1- and 3-year follow-ups. Furthermore, mesh exposure and dyspareunia were also recorded. Results In total, 138 patients (70 from the mesh group versus 68 from the conventional anterior colporrhaphy group) out of 160 (86.3%) participated in the 3-year follow-up. POP-Q revealed an objective anatomic cure for 88.1 and 91.4%, respectively, in the mesh group at the 1- and 3-year follow-ups, compared with 39.9 and 41.2% in the colporrhaphy group. No difference between the groups was observed regarding PFIQ-7, PFDI-20, and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) scores. The number of mesh exposures did not change during the study period and all exposures were minor. Conclusion Our study demonstrates that although the objective outcome was superior in the mesh group, the use of mesh had no impact on the subjective outcome. Tweetable abstract POP-Q deteriorates after anterior prolapse surgery but remains stable in women with mesh implantation. Tweetable abstract POP-Q deteriorates after anterior prolapse surgery but remains stable in women with mesh implantation.

Original languageEnglish
JournalB J O G
Volume123
Issue number1
Pages (from-to)136-142
ISSN1470-0328
DOIs
Publication statusPublished - Jan 2016

Keywords

  • Anterior colporrhaphy
  • erosion
  • pelvic organ prolapse
  • synthetic mesh
  • Prospective Studies
  • Follow-Up Studies
  • Humans
  • Norway/epidemiology
  • Gynecologic Surgical Procedures/instrumentation
  • Treatment Outcome
  • Vagina/surgery
  • Finland/epidemiology
  • Pelvic Organ Prolapse/epidemiology
  • Denmark/epidemiology
  • Surgical Mesh
  • Collagen
  • Quality of Life
  • Female
  • Surveys and Questionnaires
  • Dyspareunia/epidemiology
  • Sweden/epidemiology

Fingerprint Dive into the research topics of 'A 3-year follow-up after anterior colporrhaphy compared with collagen-coated transvaginal mesh for anterior vaginal wall prolapse: a randomised controlled trial'. Together they form a unique fingerprint.

Cite this