A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Graves' Hyperthyroidism and Graves' Orbitopathy

Roberto Negro, Laszlo Hegedüs, Roberto Attanasio, Enrico Papini, Kristian H. Winther

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: Selenium (Se) supplementation has been suggested in the treatment of Graves' disease (GD). We sought to investigate Se prescription patterns for GD across European countries. Methods: Members of the European Thyroid Association were invited to participate in an online survey investigating the use of Se in GD either without or with orbitopathy (GO). Of 872 invited members, 244 (28%) completed the survey. After exclusion of basic scientists and non-European members, 197 responses were retrieved out of clinical trials (nearly half of clinician members), of whom 61 do not use Se. Thus, 136 respondents remained for further analyses. Results: Among the 136 analyzed respondents, most (64.7%) were not aware of the Se status in their populations, did not assess Se levels (78.7%), nor considered iodine status (74.3%). In GD without GO, 38.2% recommend Se supplementation ("sometimes" [27.2%], "frequently" [5.9%] or "always" [5.1%]). When GO occurs, 94.1% recommend Se supplementation ("sometimes" [39%], "frequently" [30.1%] or "always" [25%]). Of these, 60.1% recommend Se as an alternative to watchful waiting in patients with mild ocular involvement and 44.9% as an adjuvant to the established treatment modalities in patients with moderate to severe ocular involvement. Conclusions: In Graves' hyperthyroidism without GO, 38.2% of ETA (European Thyroid Association) members recommend Se supplementation. Conversely, Se is recommended by the majority of respondents in GO, both in patients with mild and moderate to severe ocular involvement. This clinical practice is partially in disagreement with current European treatment guidelines that recommend Se as a 6-month treatment in mild GO only.

Original languageEnglish
JournalEuropean Thyroid Journal
Volume8
Issue number1
Pages (from-to)7–15
ISSN2235-0640
DOIs
Publication statusPublished - Jan 2019

Fingerprint

Selenium
Surveys and Questionnaires
Watchful Waiting
Iodine
Prescriptions
Clinical Trials
Guidelines

Keywords

  • European Thyroid Association
  • Graves' disease
  • Graves' disease treatment
  • Graves' orbitopathy
  • Questionnaire
  • Selenium supplementation

Cite this

Negro, Roberto ; Hegedüs, Laszlo ; Attanasio, Roberto ; Papini, Enrico ; Winther, Kristian H. / A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Graves' Hyperthyroidism and Graves' Orbitopathy. In: European Thyroid Journal. 2019 ; Vol. 8, No. 1. pp. 7–15.
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abstract = "Objective: Selenium (Se) supplementation has been suggested in the treatment of Graves' disease (GD). We sought to investigate Se prescription patterns for GD across European countries. Methods: Members of the European Thyroid Association were invited to participate in an online survey investigating the use of Se in GD either without or with orbitopathy (GO). Of 872 invited members, 244 (28{\%}) completed the survey. After exclusion of basic scientists and non-European members, 197 responses were retrieved out of clinical trials (nearly half of clinician members), of whom 61 do not use Se. Thus, 136 respondents remained for further analyses. Results: Among the 136 analyzed respondents, most (64.7{\%}) were not aware of the Se status in their populations, did not assess Se levels (78.7{\%}), nor considered iodine status (74.3{\%}). In GD without GO, 38.2{\%} recommend Se supplementation ({"}sometimes{"} [27.2{\%}], {"}frequently{"} [5.9{\%}] or {"}always{"} [5.1{\%}]). When GO occurs, 94.1{\%} recommend Se supplementation ({"}sometimes{"} [39{\%}], {"}frequently{"} [30.1{\%}] or {"}always{"} [25{\%}]). Of these, 60.1{\%} recommend Se as an alternative to watchful waiting in patients with mild ocular involvement and 44.9{\%} as an adjuvant to the established treatment modalities in patients with moderate to severe ocular involvement. Conclusions: In Graves' hyperthyroidism without GO, 38.2{\%} of ETA (European Thyroid Association) members recommend Se supplementation. Conversely, Se is recommended by the majority of respondents in GO, both in patients with mild and moderate to severe ocular involvement. This clinical practice is partially in disagreement with current European treatment guidelines that recommend Se as a 6-month treatment in mild GO only.",
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author = "Roberto Negro and Laszlo Heged{\"u}s and Roberto Attanasio and Enrico Papini and Winther, {Kristian H.}",
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A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Graves' Hyperthyroidism and Graves' Orbitopathy. / Negro, Roberto; Hegedüs, Laszlo; Attanasio, Roberto; Papini, Enrico; Winther, Kristian H.

In: European Thyroid Journal, Vol. 8, No. 1, 01.2019, p. 7–15.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Graves' Hyperthyroidism and Graves' Orbitopathy

AU - Negro, Roberto

AU - Hegedüs, Laszlo

AU - Attanasio, Roberto

AU - Papini, Enrico

AU - Winther, Kristian H.

PY - 2019/1

Y1 - 2019/1

N2 - Objective: Selenium (Se) supplementation has been suggested in the treatment of Graves' disease (GD). We sought to investigate Se prescription patterns for GD across European countries. Methods: Members of the European Thyroid Association were invited to participate in an online survey investigating the use of Se in GD either without or with orbitopathy (GO). Of 872 invited members, 244 (28%) completed the survey. After exclusion of basic scientists and non-European members, 197 responses were retrieved out of clinical trials (nearly half of clinician members), of whom 61 do not use Se. Thus, 136 respondents remained for further analyses. Results: Among the 136 analyzed respondents, most (64.7%) were not aware of the Se status in their populations, did not assess Se levels (78.7%), nor considered iodine status (74.3%). In GD without GO, 38.2% recommend Se supplementation ("sometimes" [27.2%], "frequently" [5.9%] or "always" [5.1%]). When GO occurs, 94.1% recommend Se supplementation ("sometimes" [39%], "frequently" [30.1%] or "always" [25%]). Of these, 60.1% recommend Se as an alternative to watchful waiting in patients with mild ocular involvement and 44.9% as an adjuvant to the established treatment modalities in patients with moderate to severe ocular involvement. Conclusions: In Graves' hyperthyroidism without GO, 38.2% of ETA (European Thyroid Association) members recommend Se supplementation. Conversely, Se is recommended by the majority of respondents in GO, both in patients with mild and moderate to severe ocular involvement. This clinical practice is partially in disagreement with current European treatment guidelines that recommend Se as a 6-month treatment in mild GO only.

AB - Objective: Selenium (Se) supplementation has been suggested in the treatment of Graves' disease (GD). We sought to investigate Se prescription patterns for GD across European countries. Methods: Members of the European Thyroid Association were invited to participate in an online survey investigating the use of Se in GD either without or with orbitopathy (GO). Of 872 invited members, 244 (28%) completed the survey. After exclusion of basic scientists and non-European members, 197 responses were retrieved out of clinical trials (nearly half of clinician members), of whom 61 do not use Se. Thus, 136 respondents remained for further analyses. Results: Among the 136 analyzed respondents, most (64.7%) were not aware of the Se status in their populations, did not assess Se levels (78.7%), nor considered iodine status (74.3%). In GD without GO, 38.2% recommend Se supplementation ("sometimes" [27.2%], "frequently" [5.9%] or "always" [5.1%]). When GO occurs, 94.1% recommend Se supplementation ("sometimes" [39%], "frequently" [30.1%] or "always" [25%]). Of these, 60.1% recommend Se as an alternative to watchful waiting in patients with mild ocular involvement and 44.9% as an adjuvant to the established treatment modalities in patients with moderate to severe ocular involvement. Conclusions: In Graves' hyperthyroidism without GO, 38.2% of ETA (European Thyroid Association) members recommend Se supplementation. Conversely, Se is recommended by the majority of respondents in GO, both in patients with mild and moderate to severe ocular involvement. This clinical practice is partially in disagreement with current European treatment guidelines that recommend Se as a 6-month treatment in mild GO only.

KW - European Thyroid Association

KW - Graves' disease

KW - Graves' disease treatment

KW - Graves' orbitopathy

KW - Questionnaire

KW - Selenium supplementation

U2 - 10.1159/000494837

DO - 10.1159/000494837

M3 - Journal article

VL - 8

SP - 7

EP - 15

JO - European Thyroid Journal

JF - European Thyroid Journal

SN - 2235-0640

IS - 1

ER -