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  • 2019
  • 2018
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Author

  • Jesper Wengel
2019

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, In : Theranostics. 9, 9, p. 2662-2677

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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136 Downloads (Pure)

Combining nucleic acid mimics and spectral imaging with fluorescence in situ hybridization for the analysis of the gastric micro-biogeography

Azevedo, A. S., Teixeira, H., Ferreira, R., Figueiredo, C., Wengel, J., Almeida, C. & Azevedo, N., 1. Sep 2019, In : Helicobacter. 24, Suppl. 1, p. 21 1 p., W6.2.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28. Jan 2019, In : Journal of Controlled Release. 294, p. 247-258

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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212 Downloads (Pure)

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14. Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2499-2507

Research output: Contribution to journalJournal articleResearchpeer-review

Inhibition of miR-29a and miR-146a accelerates the wound closure in a mouse model of type 1 diabetes

Petkovic, M., Leal, E. C., Sorensen, A. E., Ottesen, J. T., Jorgensen, P. T., Wengel, J., Carvalho, E. & Dalgaard, L. T., 1. Sep 2019, In : Diabetologia. 62, Suppl. I, p. S53 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9. Apr 2019, In : Scientific Reports. 9, 11 p., 5836.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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137 Downloads (Pure)

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

Gasparri, F., Wengel, J., Grutter, T. & Pless, S. A., 1. Jul 2019, In : Journal of General Physiology. 151, 7, p. 898-911 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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88 Downloads (Pure)

Oligonucleotide binding to non-B-DNA in MYC

Umek, T., Sollander, K., Bergquist, H., Wengel, J., Lundin, K. E., Edvard Smith, C. I. & Zain, R., 12. Mar 2019, In : Molecules. 24, 5, 11 p., 1000.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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114 Downloads (Pure)

Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides

Yadav, Y., Sharma, D., Kaushik, K., Kumar, V., Jha, A., Prasad, A. K., Len, C., Malhotra, S. V., Wengel, J. & Parmar, V. S., 30. Oct 2019, In : Molecules. 24, 21, 16 p., 3922.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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84 Downloads (Pure)

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Xu, Y., Gissberg, O., Pabon-Martinez, Y. V., Wengel, J., Lundin, K. E., Smith, C. I. E., Zain, R., Nilsson, L. & Villa, A., 2019, In : PLOS ONE. 14, 2, 14 p., e0211651.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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146 Downloads (Pure)
2018

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

Garcia, J., Stein, J., Cai, Y., Wexselblatt, E., Creemers, L., Wengel, J., Howard, K., Saris, D. & Yayon, A., 1. Apr 2018, In : Osteoarthritis and Cartilage. 26, Suppl. 1, p. S145

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Moreno, P. M. D., Ferreira, A. R., Salvador, D., Rodrigues, M. T., Torrado, M., Carvalho, E. D., Tedebark, U., Sousa, M. M., Amaral, I. F., Wengel, J. & Pêgo, A. P., 2018, In : Molecular Therapy - Nucleic Acids. 11, p. 393-406

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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298 Downloads (Pure)

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J. & Xodo, L. E., 2018, In : RNA Biology. 15, 10, p. 1273-1285

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
161 Downloads (Pure)

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Ejlersen, M., Lou, C., Sanghvi, Y. S., Tor, Y. & Wengel, J., 12. Jul 2018, In : Chemical Communications. 54, 57, p. 8003-8006

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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113 Downloads (Pure)

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

Vejlegaard, K., Wegeberg, C., McKee, V. & Wengel, J., 2018, In : Organic & Biomolecular Chemistry. 16, 8, p. 1312-1321

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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149 Downloads (Pure)

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

Cai, Y., Makarova, A-M., Wengel, J. & Howard, K. A., 2018, In : Journal of Gene Medicine. 20, 7-8, p. 1-6

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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127 Downloads (Pure)

Peptide-Oligonucleotide Conjugates as Nanoscale Building Blocks

Boesen, J., Sorensen, K., Lou, C., Wengel, J. & Jensen, K. J., 1. Sep 2018, In : Journal of Peptide Science. 24, Suppl. 2, p. S157 1 p.

Research output: Contribution to journalConference abstract in journalResearch

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA

Ejlersen, M., Christensen, N. J., Sørensen, K. K., Jensen, K. J., Wengel, J. & Lou, C., 2018, In : Bioconjugate Chemistry. 29, 4, p. 1025–1029

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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134 Downloads (Pure)

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides

Lima, J. F., Carvalho, J., Pinto-Ribeiro, I., Almeida, C., Wengel, J., Cerqueira, L., Figueiredo, C., Oliveira, C. & Azevedo, N. F., 7. Jun 2018, In : BMC Molecular Biology. 19, 13 p., 6.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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142 Downloads (Pure)

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Kotkowiak, W., Lisowiec-Wachnicka, J., Grynda, J., Kierzek, R., Wengel, J. & Pasternak, A., 2018, In : Molecular Therapy - Nucleic Acids. 10, p. 304-316

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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119 Downloads (Pure)

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens

Le, B. T., Hughes, Q., Rakesh, S., Baker, R., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2018, In : RSC Advances. 8, 57, p. 32770-32774

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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143 Downloads (Pure)
2017

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes

Ejlersen, M., Langkjær, N. & Wengel, J., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2073-2085

Research output: Contribution to journalJournal articleResearchpeer-review

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Cai, Y., López-Ruiz, E., Wengel, J., Creemers, L. B. & Howard, K. A., 2017, In : Journal of controlled release : official journal of the Controlled Release Society. 253, p. 153-159

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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188 Downloads (Pure)

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J. S., Sohn, E., Bienk, K., Schaffert, D., Sørensen, E. S., Wengel, J., Dupont, D. M. & Howard, K. A., 2017, In : Molecular Therapy - Nucleic Acids. 9, p. 284-293

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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188 Downloads (Pure)

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Zaghloul, E. M., Gissberg, O., Moreno, P. M. D., Siggens, L., Hällbrink, M., Jørgensen, A. S., Ekwall, K., Zain, R., Wengel, J., Lundin, K. E. & Smith, C. I. E., 2017, In : Nucleic Acids Research. 45, 9, p. 5153-5169

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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329 Downloads (Pure)

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule

Aaldering, L. J., Poongavanam, V., Langkjær, N., Murugan, N. A., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2017, In : ChemBioChem. 18, 8, p. 755–763

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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190 Downloads (Pure)

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J. S., Wengel, J., Kjems, J. & Howard, K. A., 2017, In : Molecular Therapy. 25, 7, p. 1710-1717

Research output: Contribution to journalJournal articleResearchpeer-review

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151 Downloads (Pure)

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

Lou, C., Christensen, N. J., Martos-Maldonado, M. C., Midtgaard, S. R., Ejlersen, M., Thulstrup, P. W., Sørensen, K. K., Jensen, K. J. & Wengel, J., 2017, In : Chemistry: A European Journal. 23, 39, p. 9297–9305

Research output: Contribution to journalJournal articleResearchpeer-review

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174 Downloads (Pure)

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

Pabon-Martinez, Y. V., Xu, Y., Villa, A., Lundin, K. E., Geny, S., Nguyen, C-H., Pedersen, E. B., Jørgensen, P. T., Wengel, J., Nilsson, L., Smith, C. I. E. & Zain, R., 2017, In : Scientific Reports. 7, 1, 16 p., 11043.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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243 Downloads (Pure)

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

Kristensen, K. V., Paul, S., Kosbar, T., Wengel, J. & Caruthers, M. H., 2017, In : Bioorganic & Medicinal Chemistry Letters. 27, 14, p. 3173–3176

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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286 Downloads (Pure)

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA

Lou, C., Samuelsen, S. V., Christensen, N. J., Vester, B. & Wengel, J., 2017, In : Bioconjugate Chemistry. 28, 4, p. 1214-1220

Research output: Contribution to journalJournal articleResearchpeer-review

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

Hartono, Y. D., Pabon-Martinez, Y. V., Uyar, A., Wengel, J., Lundin, K. E., Zain, R., Smith, C. I. E., Nilsson, L. & Villa, A., 2017, In : ACS Omega. 2, 5, p. 2165-2177 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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263 Downloads (Pure)

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding

Schmøkel, J., Voldum, A., Tsakiridou, G., Kuhlmann, M., Cameron, J., Sørensen, E. S., Wengel, J. & Howard, K. A., 2017, In : Nanotechnology. 28, 20, 9 p., 204004.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units

Kumar, R., Ries, A. & Wengel, J., 2017, In : Molecules. 22, 5, 13 p., 852.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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208 Downloads (Pure)