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Publication Year

  • 2019
  • 2017
  • 2016

Author

  • Jesper Wengel
Conference abstract in journal

Combining nucleic acid mimics and spectral imaging with fluorescence in situ hybridization for the analysis of the gastric micro-biogeography

Azevedo, A. S., Teixeira, H., Ferreira, R., Figueiredo, C., Wengel, J., Almeida, C. & Azevedo, N., 1. Sep 2019, In : Helicobacter. 24, Suppl. 1, p. 21 1 p., W6.2.

Research output: Contribution to journalConference abstract in journal

Inhibition of miR-29a and miR-146a accelerates the wound closure in a mouse model of type 1 diabetes

Petkovic, M., Leal, E. C., Sorensen, A. E., Ottesen, J. T., Jorgensen, P. T., Wengel, J., Carvalho, E. & Dalgaard, L. T., 1. Sep 2019, In : Diabetologia. 62, Suppl. I, p. S53 1 p.

Research output: Contribution to journalConference abstract in journal

Journal article

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes

Ejlersen, M., Langkjær, N. & Wengel, J., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2073-2085

Research output: Contribution to journalJournal article

Open Access
File
195 Downloads (Pure)

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

Bienk, K., Hvam, M. L., Pakula, M. M., Dagnæs-Hansen, F., Wengel, J., Malle, B. M., Kragh-Hansen, U., Cameron, J., Bukrinski, J. T. & Howard, K. A., 2016, In : Journal of Controlled Release. 232, p. 143-151

Research output: Contribution to journalJournal article

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J. S., Sohn, E., Bienk, K., Schaffert, D., Sørensen, E. S., Wengel, J., Dupont, D. M. & Howard, K. A., 2017, In : Molecular Therapy - Nucleic Acids. 9, p. 284-293

Research output: Contribution to journalJournal article

Open Access
File
200 Downloads (Pure)

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

Fontenete, S., Carvalho, D. R., Guimarães, N., Madureira, P., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2016, In : Applied Microbiology and Biotechnology. 100, 13, p. 5897-5906

Research output: Contribution to journalJournal article

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, In : Theranostics. 9, 9, p. 2662-2677

Research output: Contribution to journalJournal article

Open Access
File
144 Downloads (Pure)

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Zaghloul, E. M., Gissberg, O., Moreno, P. M. D., Siggens, L., Hällbrink, M., Jørgensen, A. S., Ekwall, K., Zain, R., Wengel, J., Lundin, K. E. & Smith, C. I. E., 2017, In : Nucleic Acids Research. 45, 9, p. 5153-5169

Research output: Contribution to journalJournal article

Open Access
File
335 Downloads (Pure)

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs

Gissberg, O., Zaghloul, E. M., Lundin, K. E., Nguyen, C-H., Landras-Guetta, C., Wengel, J., Zain, R. & Smith, C. I. E., 2016, In : Nucleic Acid Therapeutics. 26, 3, p. 183-189

Research output: Contribution to journalJournal article

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule

Aaldering, L. J., Poongavanam, V., Langkjær, N., Murugan, N. A., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2017, In : ChemBioChem. 18, 8, p. 755–763

Research output: Contribution to journalJournal article

Open Access
File
198 Downloads (Pure)

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J. S., Wengel, J., Kjems, J. & Howard, K. A., 2017, In : Molecular Therapy. 25, 7, p. 1710-1717

Research output: Contribution to journalJournal article

Open Access
File
155 Downloads (Pure)

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28. Jan 2019, In : Journal of Controlled Release. 294, p. 247-258

Research output: Contribution to journalJournal article

Open Access
File
219 Downloads (Pure)

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

Fontenete, S., Leite, M., Cappoen, D., Santos, R., Ginneken, C. V., Figueiredo, C., Wengel, J., Cos, P. & Azevedo, N. F., 2016, In : P L o S One. 11, 2, 18 p., e0148353.

Research output: Contribution to journalJournal article

Open Access
File
336 Downloads (Pure)

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

Lou, C., Christensen, N. J., Martos-Maldonado, M. C., Midtgaard, S. R., Ejlersen, M., Thulstrup, P. W., Sørensen, K. K., Jensen, K. J. & Wengel, J., 2017, In : Chemistry: A European Journal. 23, 39, p. 9297–9305

Research output: Contribution to journalJournal article

Open Access
File
197 Downloads (Pure)

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14. Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2499-2507

Research output: Contribution to journalJournal article

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

Pabon-Martinez, Y. V., Xu, Y., Villa, A., Lundin, K. E., Geny, S., Nguyen, C-H., Pedersen, E. B., Jørgensen, P. T., Wengel, J., Nilsson, L., Smith, C. I. E. & Zain, R., 2017, In : Scientific Reports. 7, 1, 16 p., 11043.

Research output: Contribution to journalJournal article

Open Access
File
247 Downloads (Pure)

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9. Apr 2019, In : Scientific Reports. 9, 11 p., 5836.

Research output: Contribution to journalJournal article

Open Access
File
148 Downloads (Pure)

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

Gasparri, F., Wengel, J., Grutter, T. & Pless, S. A., 1. Jul 2019, In : Journal of General Physiology. 151, 7, p. 898-911 14 p.

Research output: Contribution to journalJournal article

Open Access
File
90 Downloads (Pure)

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Geny, S., Moreno, P. M. D., Krzywkowski, T., Gissberg, O., Andersen, N. K., Isse, A. J., El-Madani, A. M., Lou, C., Pabon, Y. V., Anderson, B. A., Zaghloul, E. M., Zain, R., Hrdlicka, P. J., Jørgensen, P. T., Nilsson, M., Lundin, K. E., Pedersen, E. B., Wengel, J. & Smith, C. I. E., 18. Mar 2016, In : Nucleic Acids Research. 44, 5, p. 2007-2019

Research output: Contribution to journalJournal article

Open Access
File
394 Downloads (Pure)

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

Kristensen, K. V., Paul, S., Kosbar, T., Wengel, J. & Caruthers, M. H., 2017, In : Bioorganic & Medicinal Chemistry Letters. 27, 14, p. 3173–3176

Research output: Contribution to journalJournal article

Open Access
File
291 Downloads (Pure)

Oligonucleotide binding to non-B-DNA in MYC

Umek, T., Sollander, K., Bergquist, H., Wengel, J., Lundin, K. E., Edvard Smith, C. I. & Zain, R., 12. Mar 2019, In : Molecules. 24, 5, 11 p., 1000.

Research output: Contribution to journalJournal article

Open Access
File
117 Downloads (Pure)

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA

Lou, C., Samuelsen, S. V., Christensen, N. J., Vester, B. & Wengel, J., 2017, In : Bioconjugate Chemistry. 28, 4, p. 1214-1220

Research output: Contribution to journalJournal article

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J., 2016, In : Nature Communications. 7, p. 1-9 12294.

Research output: Contribution to journalJournal article

Open Access
File
218 Downloads (Pure)

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models

Fontenete, S., Guimarães, N., Wengel, J. & Azevedo, N. F., 2016, In : Critical Reviews in Biotechnology. 36, 3, p. 566-577

Research output: Contribution to journalJournal article

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

Hartono, Y. D., Pabon-Martinez, Y. V., Uyar, A., Wengel, J., Lundin, K. E., Zain, R., Smith, C. I. E., Nilsson, L. & Villa, A., 2017, In : ACS Omega. 2, 5, p. 2165-2177 13 p.

Research output: Contribution to journalJournal article

Open Access
File
271 Downloads (Pure)

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding

Schmøkel, J., Voldum, A., Tsakiridou, G., Kuhlmann, M., Cameron, J., Sørensen, E. S., Wengel, J. & Howard, K. A., 2017, In : Nanotechnology. 28, 20, 9 p., 204004.

Research output: Contribution to journalJournal article

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2'-Amino-LNA Monomers

Ries, A., Kumar, R., Lou, C., Kosbar, T., Vengut-Climent, E., Jørgensen, P. T., Morales, J. C. & Wengel, J., 13. Oct 2016, In : The Journal of Organic Chemistry. 81, 22, p. 10845-10856

Research output: Contribution to journalJournal article

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units

Kumar, R., Ries, A. & Wengel, J., 2017, In : Molecules. 22, 5, 13 p., 852.

Research output: Contribution to journalJournal article

Open Access
File
218 Downloads (Pure)

Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides

Yadav, Y., Sharma, D., Kaushik, K., Kumar, V., Jha, A., Prasad, A. K., Len, C., Malhotra, S. V., Wengel, J. & Parmar, V. S., 30. Oct 2019, In : Molecules. 24, 21, 16 p., 3922.

Research output: Contribution to journalJournal article

Open Access
File
92 Downloads (Pure)

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Xu, Y., Gissberg, O., Pabon-Martinez, Y. V., Wengel, J., Lundin, K. E., Smith, C. I. E., Zain, R., Nilsson, L. & Villa, A., 2019, In : PLOS ONE. 14, 2, 14 p., e0211651.

Research output: Contribution to journalJournal article

Open Access
File
165 Downloads (Pure)
Poster

Evaluation of nucleolin and somatostatin receptor targeting for therapeutic delivery to lung cancer stem cells

Hansen, P. L., Holmboe, S., Olsen, B. B., Thisgaard, H., Christiansen, H., Schmidt, S., Block, I., Müller, C., Langkjær, N., Jørgensen, P. T., Vogel, S., Wengel, J., Høilund-Carlsen, P. F. & Mollenhauer, J., 27. Jun 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review