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Publication Year

  • 2019
  • 2018
  • 2015

Author

  • Jesper Wengel
Conference abstract in journal

Combining nucleic acid mimics and spectral imaging with fluorescence in situ hybridization for the analysis of the gastric micro-biogeography

Azevedo, A. S., Teixeira, H., Ferreira, R., Figueiredo, C., Wengel, J., Almeida, C. & Azevedo, N., 1. Sep 2019, In : Helicobacter. 24, Suppl. 1, p. 21 1 p., W6.2.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

Garcia, J., Stein, J., Cai, Y., Wexselblatt, E., Creemers, L., Wengel, J., Howard, K., Saris, D. & Yayon, A., 1. Apr 2018, In : Osteoarthritis and Cartilage. 26, Suppl. 1, p. S145

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Inhibition of miR-29a and miR-146a accelerates the wound closure in a mouse model of type 1 diabetes

Petkovic, M., Leal, E. C., Sorensen, A. E., Ottesen, J. T., Jorgensen, P. T., Wengel, J., Carvalho, E. & Dalgaard, L. T., 1. Sep 2019, In : Diabetologia. 62, Suppl. I, p. S53 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Peptide-Oligonucleotide Conjugates as Nanoscale Building Blocks

Boesen, J., Sorensen, K., Lou, C., Wengel, J. & Jensen, K. J., 1. Sep 2018, In : Journal of Peptide Science. 24, Suppl. 2, p. S157 1 p.

Research output: Contribution to journalConference abstract in journalResearch

Journal article

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, In : Theranostics. 9, 9, p. 2662-2677

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
126 Downloads (Pure)

Detection and discrimination of biofilm populations using locked nucleic acid/2'-O-methyl-RNA fluorescence in situ hybridization (LNA/2'OMe-FISH)

Azevedo, A. S., Almeida, C., Pereira, B., Madureira, P., Wengel, J. & Azevedo, N. F., 2015, In : Biochemical Engineering Journal. 104, 15 December, p. 64-73 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Santos, R. S., Dakwar, G. R., Xiong, R., Forier, K., Remaut, K., Stremersch, S., Guimarães, N., Fontenete, S., Wengel, J., Leite, M., Figueiredo, C., De Smedt, S. C., Braeckmans, K. & Azevedo, N. F., 10. Dec 2015, In : Molecular Therapy - Nucleic Acids. 4, p. e269 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
163 Downloads (Pure)

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28. Jan 2019, In : Journal of Controlled Release. 294, p. 247-258

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
198 Downloads (Pure)

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Moreno, P. M. D., Ferreira, A. R., Salvador, D., Rodrigues, M. T., Torrado, M., Carvalho, E. D., Tedebark, U., Sousa, M. M., Amaral, I. F., Wengel, J. & Pêgo, A. P., 2018, In : Molecular Therapy - Nucleic Acids. 11, p. 393-406

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
283 Downloads (Pure)

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14. Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2499-2507

Research output: Contribution to journalJournal articleResearchpeer-review

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9. Apr 2019, In : Scientific Reports. 9, 11 p., 5836.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
131 Downloads (Pure)

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J. & Xodo, L. E., 2018, In : RNA Biology. 15, 10, p. 1273-1285

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
145 Downloads (Pure)

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids

Fontenete, S., Joana, B., Pedro, M., Céu, F., Wengel, J. & Filipe, A. N., May 2015, In : Applied Microbiology and Biotechnology. 99, 9, p. 3961-3969

Research output: Contribution to journalJournal articleResearchpeer-review

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

Opazo, F., Eiden, L., Hansen, L., Rohrbach, F., Wengel, J., Kjems, J. & Mayer, G., 2015, In : Molecular Therapy - Nucleic Acids. 4, 10 p., e251.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
183 Downloads (Pure)

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

Gasparri, F., Wengel, J., Grutter, T. & Pless, S. A., 1. Jul 2019, In : Journal of General Physiology. 151, 7, p. 898-911 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
78 Downloads (Pure)

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

Vejlegaard, K., Wegeberg, C., McKee, V. & Wengel, J., 2018, In : Organic & Biomolecular Chemistry. 16, 8, p. 1312-1321

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
139 Downloads (Pure)

Oligonucleotide binding to non-B-DNA in MYC

Umek, T., Sollander, K., Bergquist, H., Wengel, J., Lundin, K. E., Edvard Smith, C. I. & Zain, R., 12. Mar 2019, In : Molecules. 24, 5, 11 p., 1000.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
106 Downloads (Pure)

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance

Lou, C., Vester, B. & Wengel, J., 9. Feb 2015, In : Chemical Communications. 51, 19, p. 4024-4027

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
189 Downloads (Pure)

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

Cai, Y., Makarova, A-M., Wengel, J. & Howard, K. A., 2018, In : Journal of Gene Medicine. 20, 7-8, p. 1-6

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
115 Downloads (Pure)

Selection of LNA-containing DNA aptamers against recombinant human CD73

Elle, I. C., Karlsen, K. K., Terp, M. G., Larsen, N., Nielsen, R., Derbyshire, N., Mandrup, S., Ditzel, H. J. & Wengel, J., 21. Apr 2015, In : Molecular BioSystems. 11, 5, p. 1260-1270

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
227 Downloads (Pure)

Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides

Yadav, Y., Sharma, D., Kaushik, K., Kumar, V., Jha, A., Prasad, A. K., Len, C., Malhotra, S. V., Wengel, J. & Parmar, V. S., 30. Oct 2019, In : Molecules. 24, 21, 16 p., 3922.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
74 Downloads (Pure)

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides

Lima, J. F., Carvalho, J., Pinto-Ribeiro, I., Almeida, C., Wengel, J., Cerqueira, L., Figueiredo, C., Oliveira, C. & Azevedo, N. F., 7. Jun 2018, In : BMC Molecular Biology. 19, 13 p., 6.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
133 Downloads (Pure)

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

Edwards, S. L., Poongavanam, V., R Kanwar, J., Roy, K., M. Hillman, K., Prasad, N., Leth-Larsen, R., Petersen, M., Marusic, M., Plavec, J., Wengel, J. & Veedu, R. N., 7. May 2015, In : Chemical Communications. 51, 46, p. 9499-9502

Research output: Contribution to journalJournal articleResearchpeer-review

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Xu, Y., Gissberg, O., Pabon-Martinez, Y. V., Wengel, J., Lundin, K. E., Smith, C. I. E., Zain, R., Nilsson, L. & Villa, A., 2019, In : PLOS ONE. 14, 2, 14 p., e0211651.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
141 Downloads (Pure)

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Kotkowiak, W., Lisowiec-Wachnicka, J., Grynda, J., Kierzek, R., Wengel, J. & Pasternak, A., 2018, In : Molecular Therapy - Nucleic Acids. 10, p. 304-316

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
112 Downloads (Pure)

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

Fontenete, S., Leite, M., Guimarães, N., Madureira, P., Ferreira, R. M., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2015, In : PLOS ONE. 10, 4, p. e0125494 22 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
368 Downloads (Pure)

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens

Le, B. T., Hughes, Q., Rakesh, S., Baker, R., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2018, In : RSC Advances. 8, 57, p. 32770-32774

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
134 Downloads (Pure)

Watson-Crick hydrogen bonding of unlocked nucleic acids

Langkjær, N., Wengel, J. & Pasternak, A., 15. Nov 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 22, p. 5064-6 3 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Letter

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Ejlersen, M., Lou, C., Sanghvi, Y. S., Tor, Y. & Wengel, J., 12. Jul 2018, In : Chemical Communications. 54, 57, p. 8003-8006

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
106 Downloads (Pure)

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA

Ejlersen, M., Christensen, N. J., Sørensen, K. K., Jensen, K. J., Wengel, J. & Lou, C., 2018, In : Bioconjugate Chemistry. 29, 4, p. 1025–1029

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
125 Downloads (Pure)