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2019

A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24

Mirza, M. R., Bergmann, T. K., Mau-Sørensen, M., Christensen, R. D., Åvall-Lundqvist, E., Birrer, M. J., Jørgensen, M., Roed, H., Malander, S., Nielsen, F., Lassen, U., Brøsen, K., Bjørge, L. & Mäenpää, J., Oct 2019, In : Cancer Chemotherapy and Pharmacology. 84, 4, p. 791-798

Research output: Contribution to journalJournal articleResearchpeer-review

Platinum
Angiogenesis Inhibitors
Germ-Line Mutation
Ovarian Neoplasms
Disease-Free Survival

A randomised, double-blind, placebo-controlled trial of metformin on myocardial efficiency in insulin-resistant chronic heart failure patients without diabetes

Larsen, A. H., Jessen, N., Nørrelund, H., Tolbod, L. P., Harms, H. J., Feddersen, S., Nielsen, F., Brøsen, K., Hansson, N. H., Frøkiaer, J., Poulsen, S. H., Sörensen, J. & Wiggers, H., 21. Dec 2019, In : European Journal of Heart Failure.

Research output: Contribution to journalJournal articleResearchpeer-review

Placebos
Insulin
Oxygen Consumption
Confidence Intervals
Exercise

Farmakogenetik/farmakogenomik

Brøsen, K., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 119-128

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

Hepatic exposure of metformin in patients with non-alcoholic fatty liver disease

Sundelin, E. I. O., Gormsen, L. C., Heebøll, S., Vendelbo, M. H., Jakobsen, S., Munk, O. L., Feddersen, S., Brøsen, K., Hamilton-Dutoit, S. J., Pedersen, S. B., Grønbaek, H. & Jessen, N., Aug 2019, In : British Journal of Clinical Pharmacology. 85, 8, p. 1761-1770

Research output: Contribution to journalJournal articleResearchpeer-review

Liver
Cations
Type 2 Diabetes Mellitus
Insulin Resistance
Western World

Lægemiddelforbrug

Hallas, J., Andersen, M. & Brøsen, K., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 1138-1142

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

Lægemiddelinteraktioner

Bergmann, T. K., Brøsen, K. & Christensen, H. R., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 992-1000

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

Lægemidlers elimination

Brøsen, K., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 100-118

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

Lægemidlers skæbne i organismen

Brøsen, K., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 65-99

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

Metformin increases endogenous glucose production in non-diabetic individuals and individuals with recent-onset type 2 diabetes

Gormsen, L. C., Søndergaard, E., Christensen, N. L., Brøsen, K., Jessen, N. & Nielsen, S., 1. Jul 2019, In : Diabetologia. 62, 7, p. 1251-1256

Research output: Contribution to journalLetterResearchpeer-review

Type 2 Diabetes Mellitus
Placebos
Glucose Clamp Technique
Random Allocation
Glucagon

Paul M. Vanhoutte

Brøsen, K., Simonsen, U. & Mulvany, M. J., Nov 2019, In : Basic & Clinical Pharmacology & Toxicology Online. 125, 5, p. 418-419 2 p.

Research output: Contribution to journalJournal articleResearch

Styret terapi og biomarkører

Damkier, P. & Brøsen, K., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 1119-1125

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

Udvalgte definitioner

Brøsen, K. & Simonsen, U., 2019, Basal og klinisk farmakologi. Brøsen, K., Dalhoff, K. & Simonsen, U. (eds.). 6. ed. FADL's Forlag, p. 1185-1196

Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

26 Downloads (Pure)

Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics

Stage, T. B., Wellhagen, G., Christensen, M. M. H., Guiastrennec, B., Brøsen, K. & Kjellsson, M. C., Jan 2019, In : Basic & Clinical Pharmacology & Toxicology. 124, 1, p. 105-114

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pharmacokinetics
Metformin
Urine
Automatic teller machines
Polymorphism
2018
89 Downloads (Pure)

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro

Stage, T. B., Graff, M., Wong, S., Rasmussen, L. L., Nielsen, F., Pottegård, A., Brøsen, K., Kroetz, D. L., Cyrus Khojasteh, S. & Damkier, P., Mar 2018, In : British Journal of Clinical Pharmacology. 84, 3, p. 510-519

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Dicloxacillin
Cytochrome P-450 CYP3A
Confidence Intervals
Cytochrome P-450 Enzyme System
Hepatocytes
145 Downloads (Pure)

Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes

Stage, T. B., Christensen, M-M. H., Jørgensen, N. R., Beck-Nielsen, H., Brøsen, K., Gram, J. & Frost, M., Jul 2018, In : Bone. 112, p. 35-41

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
rosiglitazone
Type 2 Diabetes Mellitus
Insulin
Placebos
Hypoglycemic Agents

Letter from the Editor

Brøsen, K., Jan 2018, In : Basic & Clinical Pharmacology & Toxicology. 122, 1, p. 3-4

Research output: Contribution to journalEditorialResearch

Obituary

Brøsen, K., Simonsen, U. & Gether, U., Nov 2018, In : Basic & Clinical Pharmacology & Toxicology. 123, 5, p. 521-522

Research output: Contribution to journalComment/debateCommunication

94 Downloads (Pure)

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

Mccreight, L. J., Stage, T. B., Connelly, P., Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brøsen, K. & Pearson, E. R., Jul 2018, In : Diabetes, Obesity and Metabolism. 20, 7, p. 1593-1601

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pharmacokinetics
Lactic Acid
Area Under Curve
Enterocytes
Intestines
3 Downloads (Pure)

Preface

Brøsen, K. & Damkier, P., 2018, Pharmacogenetics. Brøsen, K. & Damkier, P. (eds.). Academic Press, Vol. 83. p. xv-xvi (Advances in Pharmacology, Vol. 83).

Research output: Chapter in Book/Report/Conference proceedingPreface/postscriptResearchpeer-review

Open Access
File
32 Downloads (Pure)

Use of Dicloxacillin and Risk of Pregnancy among Users of Oral Contraceptives

Pottegård, A., Broe, A., Stage, T. B., Brøsen, K., Hallas, J. & Damkier, P., Sep 2018, In : Basic & Clinical Pharmacology & Toxicology. 123, 3, p. 288-293

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Dicloxacillin
Oral Contraceptives
Odds Ratio
Accidental Falls
Anti-Bacterial Agents
2017

Clopidogrel paclitaxel drug-drug interaction: A pharmacoepidemiologic study

Agergaard, K., Mau-Sørensen, M., Stage, T. B., Jørgensen, T. L., Hassel, R. E., Dahl Steffensen, K., Pedersen, J. W., Milo, M. L. H., Poulsen, S. H., Pottegård, A., Hallas, J., Brøsen, K. & Bergmann, T. K., Sep 2017, In : Clinical Pharmacology and Therapeutics. 102, 3, p. 547–553

Research output: Contribution to journalJournal articleResearchpeer-review

clopidogrel
Drug Interactions
Pharmaceutical Preparations
Confidence Intervals
Glucuronides

Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans

Sundelin, E. I. O., Gormsen, L. C., Jensen, J. B., Vendelbo, M. H., Jakobsen, S., Munk, O. L., Christensen, M. M. H., Brøsen, K., Frøkiaer, J. & Jessen, N., 2017, In : Clinical Pharmacology and Therapeutics. 102, p. 841-848

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Polymorphisms
Liver
Pharmacogenetics
Type 2 Diabetes Mellitus
Pharmacokinetics

Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics

Nielsen, L. M., Sverrisdóttir, E., Stage, T. B., Feddersen, S., Brøsen, K., Christrup, L. L., Drewes, A. M. & Olesen, A. E., 2017, In : European Journal of Pharmaceutical Sciences. 99, p. 337-342

Research output: Contribution to journalJournal articleResearchpeer-review

Glucuronosyltransferase
Morphine
Protein Isoforms
Pharmacokinetics
Muscles

Letter from the Editor

Brøsen, K., 2017, In : Basic & Clinical Pharmacology & Toxicology. 120, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorialResearch

Mogens Brandt Kristensen

Brøsen, K. & Bredesen, J. L., 1. Mar 2017, In : Ugeskrift for Laeger. 179, 11, 1 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Open letter on access to the BIA 10-2474 clinical trial data

Brøsen, K., Funck-Brentano, C., Kroemer, H. K., Pirmohamed, M. & Schwab, M., 2017, In : The Lancet Oncology. 389, 10065, p. 156 1 p.

Research output: Contribution to journalComment/debateResearch

Professor Jens Sølver Schou 10 October 1929-8 March 2017

Brøsen, K. & Hoppe Mouret, G., 2017, In : Basic & Clinical Pharmacology & Toxicology. 121, 1, p. 5 1 p.

Research output: Contribution to journalComment/debateCommunication

The BCPT 2016 prize to Jan Alexander, Norway

Brøsen, K., 2017, In : Basic & Clinical Pharmacology & Toxicology. 121, 1, p. 3-4

Research output: Contribution to journalEditorialResearchpeer-review

The impact of serum drug concentration on the efficacy of imipramine, pregabalin and their combination in painful polyneuropathy

Sindrup, S. H., Holbech, J. V., Bach, F. W., Finnerup, N. B., Brøsen, K. & Jensen, T. S., 15. Jun 2017.

Research output: Contribution to conference without publisher/journalPosterResearch

The Impact of Serum Drug Concentration on the Efficacy of Imipramine, Pregabalin and their Combination in Painful Polyneuropathy

Sindrup, S. H., Holbech, J. V., Bach, F. W., Finnerup, N. B., Brøsen, K. & Jensen, T. S., 2017, In : Clinical Journal of Pain. 33, 12, p. 1047-1052

Research output: Contribution to journalJournal articleResearchpeer-review

Imipramine
Serum
Pharmaceutical Preparations
Drug Interactions
Cross-Over Studies
109 Downloads (Pure)

The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients

Juul Madsen, M., Bergmann, T. K., Brøsen, K. & Thiesson, H. C., 2017, In : Drugs in R&D. 17, 2, p. 279–286

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cytochrome P-450 CYP3A
Pharmacogenetics
Tacrolimus
Adrenal Cortex Hormones
Pediatrics
111 Downloads (Pure)

Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis

Dujic, T., Zhou, K., Yee, S. W., van Leeuwen, N., de Keyser, C. E., Javorský, M., Goswami, S., Zaharenko, L., Christensen, M. M. H., Out, M., Tavendale, R., Kubo, M., Hedderson, M. M., van der Heijden, A. A., Klimčáková, L., Pirags, V., Kooy, A., Brøsen, K., Klovins, J., Semiz, S. & 6 others, Tkáč, I., Stricker, B. H., Palmer, C. N. A., 't Hart, L. M., Giacomini, K. M. & Pearson, E. R., 2017, In : Clinical Pharmacology & Therapeutics. 101, 6, p. 763-772

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Meta-Analysis
Pharmacokinetics
Type 2 Diabetes Mellitus
Pharmaceutical Preparations
2016
127 Downloads (Pure)

Antipsykotika: bivirkninger og interaktioner

Fink-Jensen, A., Hedegaard, U., Brøsen, K. & Krag, M. Ø., 2016, In : Rationel Farmakoterapi. 2016, 3, 4 p.

Research output: Contribution to journalJournal articleCommunication

Open Access
File

Clinical Pharmacology in Denmark in 2016: 40 Years with the Danish Society of Clinical Pharmacology and 20 Years as a Medical Speciality

Brøsen, K., Andersen, S. E., Borregaard, J., Christensen, H. R., Christensen, P. M., Dalhoff, K. P., Damkier, P., Hallas, J., Heisterberg, J., Jessen, N., Jürgens, G., Kampmann, J. P. K., Laursen, B. E., Laursen, T., Nielsen, L. P., Poulsen, B. K., Poulsen, H. E., Andersen, L. V., Senderovitz, T. & Sonne, J., 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 6, p. 523-532

Research output: Contribution to journalReviewResearchpeer-review

Clinical Pharmacology
Denmark
Medicine
Pharmaceutical Preparations
Information services

Early Discontinuation of Metformin in Individuals Treated with Inhibitors of Transporters of Metformin

Stage, T. B., Lee, M. P., Hallas, J., Christensen, M. M. H., Brøsen, K., Christensen, K., Gagne, J. J. & Pottegård, A., Jun 2016, In : Basic & Clinical Pharmacology & Toxicology. 118, 6, p. 487-95

Research output: Contribution to journalJournal articleResearchpeer-review

Metformin
Odds Ratio
Codeine
Pharmaceutical Preparations
Organic Cation Transporter 1

Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort

Stage, T. B., Damkier, P., Christensen, M. M. H., Nielsen, L. B-K., Højlund, K. & Brøsen, K., 2016, In : Basic & Clinical Pharmacology & Toxicology. 118, 3, p. 219-224

Research output: Contribution to journalConference articleResearchpeer-review

Hypericum
Glucose Intolerance
Glucose
Insulin
Insulin Resistance
International Normalized Ratio
Phenprocoumon
Warfarin
Hypoglycemic Agents
Pharmaceutical Preparations

In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

Gormsen, L. C., Sundelin, E. I., Jensen, J. B., Vendelbo, M. H., Jakobsen, S., Munk, O. L., Hougaard Christensen, M. M., Brøsen, K., Frøkiær, J. & Jessen, N., 2016, In : The Journal of Nuclear Medicine. 57, 12, p. 1920-1926

Research output: Contribution to journalJournal articleResearchpeer-review

Radiometry
Kidney
Skeletal Muscle
Liver
Intestines

LBA50 - Influence of concomitant clopidogrel consumption on development of paclitaxel-associated toxicity: A pharmacoepidemiological study

K, A., Mau-Sørensen, M., Stage, T. B., Dahl Steffensen, K., Hallas, J., Brøsen, K. & Bergmann, T. K., 8. Oct 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Open Access

Letter from the Editor

Brøsen, K., 2016, In : Basic & Clinical Pharmacology & Toxicology. 118, 1, p. 3 1 p.

Research output: Contribution to journalEditorialResearchpeer-review

Limited sampling strategy for determining metformin area under the plasma concentration-time curve

Santoro, A. B., Stage, T. B., Struchiner, C. J., Christensen, M. M. H., Brosen, K. & Suarez-Kurtz, G., 2016, In : British Journal of Clinical Pharmacology. 82, 4, p. 1002–1010

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Area Under Curve
Linear Models
Cohort Studies
Regression Analysis
Research Personnel

Philippe Grandjean is the 2015 BCPT Nordic Prize Awardee

Brøsen, K., Aug 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 2, p. 123-125

Research output: Contribution to journalLetterResearch

Opioid Analgesics
Sudden Death
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Methadone
371 Downloads (Pure)

The Monoamine Oxidase Inhibitor Isocarboxazid is a Relevant Treatment Option in Treatment-Resistant Depression: Experience-Based Strategies in Danish Psychiatry

Larsen, J. K., Krogh-Nielsen, L. & Brøsen, K., 2016, In : Health Care: Current Reviews. 4, 2, 4 p.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
2015

A comprehensive review on drug-drug interactions with metformin

Stage, T. B., Brøsen, K. & Christensen, M. M. H., Aug 2015, In : Clinical Pharmacokinetics. 54, 8, p. 811-824

Research output: Contribution to journalReviewResearchpeer-review