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2019
31 Downloads (Pure)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. Nov 2019, In : Cell Death & Disease. 10, 11, 12 p., 841.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

Patel, V. L., Busch, E. L., Friebel, T. M., Cronin, A., Leslie, G., McGuffog, L., Adlard, J., Agata, S., Agnarsson, B. A., Ahmed, M., Aittomäki, K., Alducci, E., Andrulis, I. L., Arason, A., Arnold, N., Artioli, G., Arver, B., Auber, B., Azzollini, J., Balmaña, J. & 243 others, Barkardottir, R. B., Barnes, D. R., Barroso, A., Barrowdale, D., Belotti, M., Benitez, J., Bertelsen, B., Blok, M. J., Bodrogi, I., Bonadona, V., Bonanni, B., Bondavalli, D., Boonen, S. E., Borde, J., Borg, A., Bradbury, A. R., Brady, A., Brewer, C., Brunet, J., Buecher, B., Buys, S. S., Cabezas-Camarero, S., Caldés, T., Caliebe, A., Caligo, M. A., Calvello, M., Campbell, I. G., Carnevali, I., Carrasco, E., Chan, T. L., Chu, A. T. W., Chung, W. K., Claes, K. B. M., Collaborators, G. S., Collaborators, E., Cook, J., Cortesi, L., Couch, F. J., Daly, M. B., Damante, G., Darder, E., Davidson, R., de la Hoya, M., Della Puppa, L., Dennis, J., Díez, O., Ding, Y. C., Ditsch, N., Domchek, S. M., Donaldson, A., Dworniczak, B., Easton, D. F., Eccles, D. M., Eeles, R. A., Ehrencrona, H., Ejlertsen, B., Engel, C., Evans, D. G., Faivre, L., Faust, U., Feliubadaló, L., Foretova, L., Fostira, F., Fountzilas, G., Frost, D., García-Barberán, V., Garre, P., Gauthier-Villars, M., Géczi, L., Gehrig, A., Gerdes, A-M., Gesta, P., Giannini, G., Glendon, G., Godwin, A. K., Goldgar, D. E., Greene, M. H., Gutierrez-Barrera, A. M., Hahnen, E., Hamann, U., Hauke, J., Herold, N., Hogervorst, F. B. L., Honisch, E., Hopper, J. L., Hulick, P. J., Investigators, KC., Investigators, H., Izatt, L., Jager, A., James, P., Janavicius, R., Jensen, U. B., Jensen, T. D., Johannsson, O. T., John, E. M., Joseph, V., Kang, E., Kast, K., Kiiski, J. I., Kim, S-W., Kim, Z., Ko, K-P., Konstantopoulou, I., Kramer, G., Krogh, L., Kruse, T. A., Kwong, A., Larsen, M., Lasset, C., Lautrup, C., Lázaro, C., Lee, J., Lee, J. W., Lee, M. H., Lemke, J., Lesueur, F., Liljegren, A., Lindblom, A., Llovet, P., Lopez-Fernández, A., Lopez-Perolio, I., Lorca, V., Loud, J. T., Ma, E. S. K., Mai, P. L., Manoukian, S., Mari, V., Martin, L., Matricardi, L., Mebirouk, N., Medici, V., Meijers-Heijboer, H. E. J., Meindl, A., Mensenkamp, A. R., Miller, C., Molina Gomes, D., Montagna, M., Mooij, T. M., Moserle, L., Mouret-Fourme, E., Mulligan, A. M., Nathanson, K. L., Navratilova, M., Nevanlinna, H., Niederacher, D., Cilius Nielsen, F. C., Nikitina-Zake, L., Offit, K., Olah, E., Olopade, O. I., Ong, K-R., Osorio, A., Ott, C-E., Palli, D., Park, S. K., Parsons, M. T., Pedersen, I. S., Peissel, B., Peixoto, A., Pérez-Segura, P., Peterlongo, P., Høgh Petersen, A., Porteous, M. E., Pujana, M. A., Radice, P., Ramser, J., Rantala, J., Rashid, M. U., Rhiem, K., Rizzolo, P., Robson, M. E., Rookus, M. A., Rossing, C. M., Ruddy, K. J., Santos, C., Saule, C., Scarpitta, R., Schmutzler, R. K., Schuster, H., Senter, L., Seynaeve, C. M., Shah, P. D., Sharma, P., Shin, V. Y., Silvestri, V., Simard, J., Singer, C. F., Skytte, A-B., Snape, K., Solano, A. R., Soucy, P., Southey, M. C., Spurdle, A. B., Steele, L., Steinemann, D., Stoppa-Lyonnet, D., Stradella, A., Sunde, L., Sutter, C., Tan, Y. Y., Teixeira, M. R., Teo, S. H., Thomassen, M., Tibiletti, M. G., Tischkowitz, M., Tognazzo, S., Toland, A. E., Tommasi, S., Torres, D., Toss, A., Trainer, A. H., Tung, N., van Asperen, C. J., van der Baan, F. H., van der Kolk, L. E., van der Luijt, R. B., van Hest, L. P., Varesco, L., Varon-Mateeva, R., Viel, A., Vierstraete, J., Villa, R., von Wachenfeldt, A., Wagner, P., Wang-Gohrke, S., Wappenschmidt, B., Weitzel, J. N., Wieme, G., Yadav, S., Yannoukakos, D., Yoon, S-Y., Zanzottera, C., Zorn, K. K., D'Amico, A. V., Freedman, M. L., Pomerantz, M. M., Chenevix-Trench, G., Antoniou, A. C., Neuhausen, S. L., Ottini, L., Nielsen, H. R. & Rebbeck, T. R., 13. Nov 2019, In : Cancer research.

Research output: Contribution to journalJournal articleResearchpeer-review

Prostatic Neoplasms
Prostate Cancer, Hereditary, 7
Genetic Association Studies

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3

Block, I., Müller, C., Sdogati, D., Pedersen, H., List, M., Jaskot, A. M., Syse, S. D., Lund Hansen, P., Schmidt, S., Christiansen, H., Casella, C., Bering Olsen, S., Blomstrøm, M. M., Riedel, A., Thomassen, M., Kruse, T. A., Karlskov Hansen, S. W., Kioschis, P. & Mollenhauer, J., 6. Jun 2019, In : Oncogene. 38, 23, p. 4560-4573

Research output: Contribution to journalJournal articleResearchpeer-review

Properdin
Up-Regulation
Growth
Neoplasms
Mutation

Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia

Garabet, L., Ghanima, W., Monceyron Jonassen, C., Skov, V., Holst, R., Mowinckel, M-C., Hans, C. H., Torben, A. K., Thomassen, M., Liebman, H., Bussel, J. B. & Sandset, P. M., 17. Feb 2019, In : Platelets. 30, 2, p. 206-212

Research output: Contribution to journalJournal articleResearchpeer-review

Thrombopoietin Receptors
P-Selectin
Idiopathic Thrombocytopenic Purpura
Plasminogen Activator Inhibitor 1
Platelet Count

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

Jacobsen, V. M., Li, S., Wang, A., Zhu, D., Liu, M., Thomassen, M., Kruse, T. A. & Tan, Q., 3. Aug 2019, In : Gynecological Endocrinology. 35, 8, p. 691-694

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Epigenomics
DNA Methylation
HLA-G Antigens
Chromosomes, Human, Pair 19

Evaluation of tumor-infiltrating lymphocytes and association with prognosis in BRCA-mutated breast cancer

Sønderstrup, I. M. H., Jensen, M. B., Ejlertsen, B., Eriksen, J. O., Gerdes, A. M., Kruse, T. A., Larsen, M. J., Thomassen, M. & Laenkholm, A. V., 4. Mar 2019, In : Acta Oncologica. 58, 3, p. 363-370

Research output: Contribution to journalJournal articleResearchpeer-review

Tumor-Infiltrating Lymphocytes
Mutation
Germ-Line Mutation
Risk Reduction Behavior
Paraffin

Genomic Profiling of a Phase III Clinical Trial of Interferon Versus Hydroxyurea in MPN Patients Reveals Mutation-Specific and Treatment-Specific Patterns of Response

Knudsen, T. A., Skov, V., Werner, L., Duke, W., Gibson, C. J., Nag, A., Thorner, A. R., Wollison, B., Lund Hansen, D., Larsen, T. S., Ellervik, C., El Fassi, D., de Stricker, K., Ocias, L. F., Brabrand, M., Weiss Bjerrum, O., Overgaard, U. M., Frederiksen, M., Kielsgaard Kristensen, T., Kruse, T. A. & 11 others, Thomassen, M., Mourits-Andersen, T., Severinsen, M. T., Jesper, S., Starklint, J., Møller, P., Neuberg, D. S., Kjær, L., Hasselbalch, H. C., Coleman Lindsley, R. & Mullally, A., 9. Dec 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Genomic Profiling of a Phase III Clinical Trial of Interferon Versus Hydroxyurea in MPN Patients Reveals Mutation-Specific and Treatment-Specific Patterns of Response

Knudsen, T. A., Skov, V., Werner, L., Duke, W., Gibson, C. J., Nag, A., Thorner, A. R., Wollison, B., Lund Hansen, D., Larsen, T. S., Ellervik, C., El Fassi, D., de Stricker, K., Ocias, L. F., Brabrand, M., Weiss Bjerrum, O., Overgaard, U. M., Frederiksen, M., Kielsgaard Kristensen, T., Kruse, T. A. & 11 others, Thomassen, M., Mourits-Andersen, H. T., Severinsen, M. T., Jesper, S., Starklint, J., Møller, P., Neuberg, D. S., Kjær, L., Hasselbalch, H. C., Coleman Lindsley, R. & Mullally, A., 13. Nov 2019, In : Blood. 134, Supplement 1, 4202.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Genomisk medicin og kunstig intelligens

Translated title of the contribution: Genomic medicine and artificial intelligenceKruse, T. A., Larsen, M. J., Tan, Q., Andersen, L. & Thomassen, M., 1. Apr 2019, In : Ugeskrift for Laeger. 181, 7A, V02190085.

Research output: Contribution to journalJournal articleResearchpeer-review

Medicine
Datasets
Clinical Decision-Making

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Lautrup, C. K. & kConFab Investigators, Sep 2019, In : Human Mutation. 40, 9, p. 1557-1578

Research output: Contribution to journalJournal articleResearchpeer-review

Virulence
Computational Biology
Pathology
Messenger RNA
Research

Molecular profiling reveals highly de-regulated insulin growth factor binding proteins in patients with myelofibrosis and related neoplasms

Skov, V., Thomassen, M., Kjær, L., Riley, C. H., Larsen, T. S., Weiss Bjerrum, O., Kruse, T. A. & Hasselbalch, H. C., 14. Jun 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

15 Downloads (Pure)

Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Elkjaer, M. L., Frisch, T., Reynolds, R., Kacprowski, T., Burton, M., Kruse, T. A., Thomassen, M., Baumbach, J. & Illes, Z., 11. Dec 2019, In : Acta Neuropathologica Communications. 7, 17 p., 205.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Endophenotypes
Heat-Shock Response
White Matter
Heat-Shock Proteins

Significantly Upregulated Thrombo-Inflammatory Genes Are Normoregulated or Significantly Downregulated during Treatment with Interferon-Alpha2 in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms

Skov, V., Riley, C. H., Thomassen, M., Kjær, L., Larsen, T. S., Kruse, T. A. & Hasselbalch, H. C., 8. Dec 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

39 Downloads (Pure)

Subtypes in BRCA-mutated breast cancer

Sønderstrup, I., Jensen, M. B., Ejlertsen, B., Eriksen, J. O., Gerdes, A. M., Kruse, T. A., Larsen, M. J., Thomassen, M. & Lænkholm, A. V., 1. Feb 2019, In : Human Pathology. 84, p. 192-201

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Germ Cells
Germ-Line Mutation
Neoplasms
Hormones
Breast Cancer 3

The Optimal Sequencing Depth of Tumor Biopsies for Identifying Clonal Cell Populations

Tabatabaeifar, S., Larsen, M. J., Thomassen, M., Larsen, S. R., Kruse, T. A. & Sørensen, J. A., 1. Sep 2019, In : Journal of Molecular Diagnostics. 21, 5, p. 790-795

Research output: Contribution to journalJournal articleResearchpeer-review

Population
Neoplasms
Research Personnel
DNA Sequence Analysis
Cluster Analysis
Open Access
File
DNA
Neoplasms
Mutation
Residual Neoplasm
2018

A Danish national effort of BRCA1/2 variant classification

Pedersen, I. S., Schmidt, A. Y., Bertelsen, B., Ernst, A., Andersen, C. L. T., Kruse, T., Rossing, M. & Thomassen, M., 2. Jan 2018, In : Acta Oncologica. 57, 1, p. 159-162

Research output: Contribution to journalComment/debateResearchpeer-review

133 Downloads (Pure)

Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer

Block, I., Burton, M., Sørensen, K. P., Andersen, L., Larsen, M. J., Bak, M., Cold, S., Thomassen, M., Tan, Q. & Kruse, T. A., 6. Feb 2018, In : OncoTarget. 9, 10, p. 9030-9042

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG

Soenderstrup, I. M. H., Laenkholm, A. V., Jensen, M. B., Eriksen, J. O., Gerdes, A. M., Hansen, T. V. O., Kruse, T. A., Larsen, M. J., Pedersen, I. S., Rossing, M., Thomassen, M. & Ejlertsen, B., Jan 2018, In : Acta Oncologica. 57, 1, p. 95-101

Research output: Contribution to journalConference articleResearchpeer-review

Disease-Free Survival
Neoplasms
Mutation
Proportional Hazards Models
Paraffin
100 Downloads (Pure)

Differential effect of surgical manipulation on gene expression in normal breast tissue and breast tumor tissue

Pedersen, I. S., Thomassen, M., Tan, Q., Kruse, T. A., Thorlacius-Ussing, O., Garne, J. P. & Krarup, H. B., 16. Nov 2018, In : Molecular Medicine. 24, 8 p., 57.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Gene Expression Profiling
Transcriptome
Freezing
120 Downloads (Pure)

Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression

Krøigård, A. B., Larsen, M. J., Lænkholm, A-V., Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Thomassen, M. & Kruse, T. A., 1. Jan 2018, In : PLOS ONE. 13, 1, 18 p., e0189887.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
metastasis
breast neoplasms
Genes
neoplasms
genes

Interferon-alfa2 Treatment of Patients with Polycythemia Vera and Related Neoplasms Impacts Deregulation of Oxidative Stress Genes and Antioxidative Defence Mechanisms. Potential Implications of IFN-Alfa Induced Changes in TP53, NRF2 and CXCR4 for Genomic Instability and CD34+ Mobilisation.

Skov, V., Riley, C. H., Thomassen, M., Kjær, L., Larsen, T. S., Weiss Bjerrum, O., Kruse, T. A. & Hasselbalch, H. C., 3. Dec 2018.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

48 Downloads (Pure)

Interim analysis of the Daliah trial - a randomized controlled phase iii clinical trial Comparing recombinant interferon alpha-2 vs. Hydroxyurea in MPN patients.

Knudsen, T. A., Lund Hansen, D., Ocias, L. F., Weiss Bjerrum, O., Brabrand, M., El Fassi, D., Frederiksen, M., Kjær, L., Kielsgaard Kristensen, T., Kruse, T. A., Mourits-Andersen, H. T., Møller, P., Overgaard, U. M., Severinsen, M. T., Skov, V. H., Stentoft, J., Starklint, J., de Stricker, K., Thomassen, M., Larsen, T. S. & 1 others, Hasselbalch, H. C., 15. Jun 2018, In : HemaSphere. 2, S1, p. 18-19 S131.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
File

Molecular heterogeneity of mantle cell lymphoma

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 4. May 2018.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

151 Downloads (Pure)

Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations

Rebbeck, T. R., Friebel, T. M., Friedman, E., Hamann, U., Huo, D., Kwong, A., Olah, E., Olopade, O. I., Solano, A. R., Teo, S-H., Thomassen, M., Weitzel, J. N., Chan, T. L., Couch, F. J., Goldgar, D. E., Kruse, T. A., Palmero, E. I., Park, S. K., Torres, D., van Rensburg, E. J. & 31 others, McGuffog, L., Parsons, M. T., Leslie, G., Aalfs, C. M., Abugattas, J., Adlard, J., Agata, S., Aittomäki, K., Andrews, L., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Asseryanis, E., Auerbach, L., Azzollini, J., Balmaña, J., Barile, M., Barkardottir, R. B., Barrowdale, D., Benitez, J., Berger, A., Berger, R., Blanco, A. M., Blazer, K. R., Blok, M. J., Bonadona, V., Gerdes, A-M., Nielsen, H. R., Skytte, A-B. & EMBRACE, May 2018, In : Human Mutation. 39, 5, p. 593-620

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Mutation
Population
Research Personnel
Germ-Line Mutation
Mutation Rate

Myeloproliferative Neoplasms in Danish Twins

Andersen, M. A., Bjerrum, O. W., Ranjan, A., Skov, V., Kruse, T. A., Thomassen, M., Skytthe, A., Hasselbalch, H. C. & Christensen, K., 3. May 2018, In : Acta Haematologica. 139, 3, p. 195-198

Research output: Contribution to journalJournal articleResearchpeer-review

Neoplasms
Monozygotic Twins
Registries
Dizygotic Twins
Cell Lineage

NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. Jun 2018.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. Jun 2018, In : EHA Learning Center. 2018, PB2322.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

58 Downloads (Pure)

Publisher Correction: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3)

Nielsen, H. M., Andersen, C. L., Westman, M., Kristensen, L. S., Asmar, F., Kruse, T. A., Thomassen, M., Larsen, T. S., Skov, V., Hansen, L. L., Bjerrum, O. W., Hasselbalch, H. C., Punj, V. & Grønbæk, K., 20. Nov 2018, In : Scientific Reports. 8, 1 p., 17311.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
File
Epigenomics
Mutation

SAFETY AND EFFICACY OF COMBINATION THERAPY OF INTERFERON ΑLPHA-2 AND RUXOLITINIB IN POLYCYTHEMIA VERA AND LOW-/INTERMEDIATE-1-RISK MYELOFIBROSIS – A ONE YEAR FOLLOW-UP UPDATE OF A PHASE II STUDY

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Skov, V., Andersen, C. B. L., Weiss Bjerrum, O., Brochmann Mortensen, N., El Fassi, D., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M. & Hasselbalch, H. C., Jun 2018, In : EHA Learning Center. 2018, PF620.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

137 Downloads (Pure)

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Andersen, C. B. L., Bjerrum, O. W., Brochmann, N., Fassi, D. E., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M., Skov, V. & Hasselbalch, H. C., 1. Aug 2018, In : Cancer Medicine. 7, 8, p. 3571-3581

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycythemia Vera
Safety
INCB018424
Neoplasms
Alleles

Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

Kjaer, L., Holmström, M. O., Cordua, S., Andersen, M. H., Svane, I. M., Thomassen, M., Kruse, T. A., Pallisgaard, N., Skov, V. & Hasselbalch, H. C., Apr 2018, In : Leukemia and Lymphoma. 59, 4, p. 973-977

Research output: Contribution to journalComment/debateCommunication

The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium

Moghadasi, S., Meeks, H. D., Vreeswijk, M. P., Janssen, L. A., Borg, Å., Ehrencrona, H., Paulsson-Karlsson, Y., Wappenschmidt, B., Engel, C., Gehrig, A., Arnold, N., Hansen, T. V. O., Thomassen, M., Jensen, U. B., Kruse, T. A., Ejlertsen, B., Gerdes, A-M., Pedersen, I. S., Caputo, S. M., Couch, F. & 20 others, Hallberg, E. J., van den Ouweland, A. M., Collée, M. J., Teugels, E., Adank, M. A., van der Luijt, R. B., Mensenkamp, A. R., Oosterwijk, J. C., Blok, M. J., Janin, N., Claes, K. B., Tucker, K., Viassolo, V., Toland, A. E., Eccles, D. E., Devilee, P., Van Asperen, C. J., Spurdle, A. B., Goldgar, D. E. & Garcia, E. B. G., Jan 2018, In : Journal of Medical Genetics. 55, 1, p. 15-20

Research output: Contribution to journalLetterResearchpeer-review

Ovarian Neoplasms
Alleles
Neoplasms
Ovariectomy
81 Downloads (Pure)

Whole Blood Gene Expression Profiling in patients undergoing colon cancer surgery identifies differential expression of genes involved in immune surveillance, inflammation and carcinogenesis

Watt, S. K., Hasselbalch, H. C., Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M. & Gögenur, I., Jun 2018, In : Surgical Oncology. 27, 2, p. 208-215

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Gene Expression Profiling
Colonic Neoplasms
Ambulatory Surgical Procedures
Down-Regulation
Chemical Databases
2017
178 Downloads (Pure)

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Li, S., Zhu, D., Duan, H., Ren, A., Glintborg, D., Andersen, M., Skov, V., Thomassen, M., Kruse, T. & Tan, Q., 1. Jan 2017, In : Oncotarget. 8, 13, p. 20656-20666

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycystic Ovary Syndrome
DNA Methylation
Epigenomics
Prolactin
DNA
137 Downloads (Pure)

Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

Myrtue Nielsen, H., Lykkegaard Andersen, C., Westman, M., Sommer Kristensen, L., Asmar, F., Kruse, T. A., Thomassen, M., Stauffer Larsen, T., Skov, V., Lotte Hansen, L., Weis Bjerrum, O., Carl Hasselbalch, H., Punj, V. & Grønbæk, K., 1. Dec 2017, In : Scientific Reports. 7, 11 p., 6774.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epigenomics
Mutation
DNA Methylation
Histones
Nucleic Acid Regulatory Sequences
136 Downloads (Pure)
Open Access
File
Cluster Analysis
Health
152 Downloads (Pure)

Genomic analyses of breast cancer progression reveal distinct routes of metastasis emergence

Krøigård, A. B., Larsen, M. J., Brasch-Andersen, C., Lænkholm, A. V., Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Thomassen, M. & Kruse, T. A., 2017, In : Scientific Reports. 7, 9 p., 43813.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Exome
Clone Cells
Research

Identification, replication and characterization of epigenetic remodelling in the aging genome

Li, S., Christiansen, L., Christensen, K., Kruse, T. A., Redmond, P., Marioni, R. E., Deary, L. J. & Tan, Q., 2017. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Epigenomics
CpG Islands
DNA
DNA Methylation
105 Downloads (Pure)

Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

Li, S., Christiansen, L., Christensen, K., Kruse, T. A., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 2017, In : Scientific Reports. 7, 1, 8 p., 8183.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epigenomics
CpG Islands
Population
DNA Methylation
108 Downloads (Pure)

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Phelan, C. M., Kuchenbaecker, K. B., Tyrer, J. P., Kar, S. P., Lawrenson, K., Winham, S. J., Dennis, J., Pirie, A., Riggan, M. J., Chornokur, G., Earp, M. A., Lyra, P. C., Lee, J. M., Coetzee, S., Beesley, J., McGuffog, L., Soucy, P., Dicks, E., Lee, A., Barrowdale, D. & 31 others, Lecarpentier, J., Leslie, G., Aalfs, C. M., Aben, K. K. H., Adams, M., Adlard, J., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Aravantinos, G., Arnold, N., Arun, B. K., Arver, B., Azzollini, J., Balmaña, J., Banerjee, S. N., Barjhoux, L., Barkardottir, R. B., Bean, Y., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bermisheva, M., Bernardini, M. Q., Birrer, M. J., Bjorge, L., Bojesen, A., Gerdes, A-M., Kruse, T. A., Thomassen, M. & AOCS study group, 2017, In : Nature Genetics. 49, 5, p. 680-691

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Mutation
Ovarian Neoplasms
Meta-Analysis
Alleles
116 Downloads (Pure)

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Adams, M., Adlard, J., Agata, S. & 31 others, Ahmed, S., Ahsan, H., Aittomäki, K., Al-Ejeh, F., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. E. M., Azzollini, J., Bacot, F., Balmaña, J., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Bojesen, A., Gerdes, A-M., Kruse, T. A., Lænkholm, A-V., Thomassen, M. & ABCTB Investigators, 2017, In : Nature Genetics. 49, 12, p. 1767–1778

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
Genome-Wide Association Study
Mutation

Investigating a case of possible field cancerization in oral squamous cell carcinoma by the use of next-generation sequencing

Tabatabaeifar, S., Larsen, M. J., Larsen, S. R., Kruse, T. A., Thomassen, M. & Sørensen, J. A., 2017, In : Oral Oncology. 68, p. 74-80

Research output: Contribution to journalJournal articleResearchpeer-review

Mutation
Neoplasms
Oral Stage
Exome
Paraffin
92 Downloads (Pure)

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-Hoeyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T. A., Thomassen, M., Troelsen, J., Hasselbalch, H. C. & Ottesen, J. T., 2017, In : PLOS ONE. 12, 8, 18 p., e0183620.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Stem cells
mathematical models
inflammation
neoplasms
Feedback
149 Downloads (Pure)

Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

Lecarpentier, J., Silvestri, V., Kuchenbaecker, K. B., Barrowdale, D., Dennis, J., McGuffog, L., Soucy, P., Leslie, G., Rizzolo, P., Navazio, A. S., Valentini, V., Zelli, V., Lee, A., Amin Al Olama, A., Tyrer, J. P., Southey, M., John, E. M., Conner, T. A., Goldgar, D. E., Buys, S. & 31 others, Janavicius, R., Steele, L., Ding, Y. C., Neuhausen, S. L., Hansen, T. V. O., Osorio, A., Weitzel, J. N., Toss, A., Medici, V., Cortesi, L., Zanna, I., Palli, D., Radice, P., Manoukian, S., Peissel, B., Azzollini, J., Viel, A., Cini, G., Damante, G., Tommasi, S., Peterlongo, P., Fostira, F., Hamann, U., Evans, D. G., Bojesen, A., Nielsen, H. R., Skytte, A-B., Krogh, L., Kruse, T. A., Thomassen, M. & EMBRACE, 2017, In : Journal of Clinical Oncology. 35, 20, p. 2240-2250

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Prostatic Neoplasms
Mutation
Odds Ratio
Neoplasms
Research Personnel

The gene expression and immunohistochemical time-course of diphenylcyclopropenone induced contact allergy in healthy humans following repeated epicutaneous challenges

Mose, K. F., Burton, M., Thomassen, M., Andersen, F., Kruse, T. A., Tan, Q., Skov, L., Almose Røpke, M., Litman, T., Clemmensen, O., Kristensen, B. W., S. Friedmann, P. & Andersen, K. E., 2017, In : Experimental Dermatology. 26, 10, p. 926–933

Research output: Contribution to journalJournal articleResearchpeer-review

Hypersensitivity
diphenylcyclopropenone
Polymerase Chain Reaction
Interleukin-17
Gene Expression Profiling

The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms

Skov, V., Riley, C. H., Thomassen, M., Kjær, L., Stauffer Larsen, T., Bjerrum, O. W., Kruse, T. A. & Hasselbalch, H. C., Aug 2017, In : Leukemia and Lymphoma. 58, 8, p. 1914-1921

Research output: Contribution to journalJournal articleResearchpeer-review

Polycythemia Vera
Neoplasms
Up-Regulation
Down-Regulation
Clonal Evolution
215 Downloads (Pure)

The subclonal structure and genomic evolution of oral squamous cell carcinoma revealed by ultra-deep sequencing

Tabatabaeifar, S., Thomassen, M., Larsen, M. J., Larsen, S. R., Kruse, T. A. & Sørensen, J. A., 2017, In : OncoTarget. 8, 10, p. 16571-16580

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Lymph Nodes
Exome
Squamous Cell Neoplasms
Mouth Neoplasms
2016
129 Downloads (Pure)

A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis

Skov, V., Burton, M., Thomassen, M., Stauffer Larsen, T., Riley, C. H., Brinch Madelung, A., Kjær, L., Bondo, H., Stamp, I., Ehinger, M., Dahl-Sørensen, R., Brochmann Mortensen, N., Nielsen, K., Thiele, J., Jensen, M. K., Weis Bjerrum, O., Kruse, T. A. & Hasselbalch, H. C., 2016, In : P L o S One. 11, 8, p. 1-15 e0161570.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
thrombocythemia
Genes
L-Lactate Dehydrogenase
lactate dehydrogenase
genes