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2019
27 Downloads (Pure)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. Nov 2019, In : Cell Death & Disease. 10, 11, 12 p., 841.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

Patel, V. L., Busch, E. L., Friebel, T. M., Cronin, A., Leslie, G., McGuffog, L., Adlard, J., Agata, S., Agnarsson, B. A., Ahmed, M., Aittomäki, K., Alducci, E., Andrulis, I. L., Arason, A., Arnold, N., Artioli, G., Arver, B., Auber, B., Azzollini, J., Balmaña, J. & 243 others, Barkardottir, R. B., Barnes, D. R., Barroso, A., Barrowdale, D., Belotti, M., Benitez, J., Bertelsen, B., Blok, M. J., Bodrogi, I., Bonadona, V., Bonanni, B., Bondavalli, D., Boonen, S. E., Borde, J., Borg, A., Bradbury, A. R., Brady, A., Brewer, C., Brunet, J., Buecher, B., Buys, S. S., Cabezas-Camarero, S., Caldés, T., Caliebe, A., Caligo, M. A., Calvello, M., Campbell, I. G., Carnevali, I., Carrasco, E., Chan, T. L., Chu, A. T. W., Chung, W. K., Claes, K. B. M., Collaborators, G. S., Collaborators, E., Cook, J., Cortesi, L., Couch, F. J., Daly, M. B., Damante, G., Darder, E., Davidson, R., de la Hoya, M., Della Puppa, L., Dennis, J., Díez, O., Ding, Y. C., Ditsch, N., Domchek, S. M., Donaldson, A., Dworniczak, B., Easton, D. F., Eccles, D. M., Eeles, R. A., Ehrencrona, H., Ejlertsen, B., Engel, C., Evans, D. G., Faivre, L., Faust, U., Feliubadaló, L., Foretova, L., Fostira, F., Fountzilas, G., Frost, D., García-Barberán, V., Garre, P., Gauthier-Villars, M., Géczi, L., Gehrig, A., Gerdes, A-M., Gesta, P., Giannini, G., Glendon, G., Godwin, A. K., Goldgar, D. E., Greene, M. H., Gutierrez-Barrera, A. M., Hahnen, E., Hamann, U., Hauke, J., Herold, N., Hogervorst, F. B. L., Honisch, E., Hopper, J. L., Hulick, P. J., Investigators, KC., Investigators, H., Izatt, L., Jager, A., James, P., Janavicius, R., Jensen, U. B., Jensen, T. D., Johannsson, O. T., John, E. M., Joseph, V., Kang, E., Kast, K., Kiiski, J. I., Kim, S-W., Kim, Z., Ko, K-P., Konstantopoulou, I., Kramer, G., Krogh, L., Kruse, T. A., Kwong, A., Larsen, M., Lasset, C., Lautrup, C., Lázaro, C., Lee, J., Lee, J. W., Lee, M. H., Lemke, J., Lesueur, F., Liljegren, A., Lindblom, A., Llovet, P., Lopez-Fernández, A., Lopez-Perolio, I., Lorca, V., Loud, J. T., Ma, E. S. K., Mai, P. L., Manoukian, S., Mari, V., Martin, L., Matricardi, L., Mebirouk, N., Medici, V., Meijers-Heijboer, H. E. J., Meindl, A., Mensenkamp, A. R., Miller, C., Molina Gomes, D., Montagna, M., Mooij, T. M., Moserle, L., Mouret-Fourme, E., Mulligan, A. M., Nathanson, K. L., Navratilova, M., Nevanlinna, H., Niederacher, D., Cilius Nielsen, F. C., Nikitina-Zake, L., Offit, K., Olah, E., Olopade, O. I., Ong, K-R., Osorio, A., Ott, C-E., Palli, D., Park, S. K., Parsons, M. T., Pedersen, I. S., Peissel, B., Peixoto, A., Pérez-Segura, P., Peterlongo, P., Høgh Petersen, A., Porteous, M. E., Pujana, M. A., Radice, P., Ramser, J., Rantala, J., Rashid, M. U., Rhiem, K., Rizzolo, P., Robson, M. E., Rookus, M. A., Rossing, C. M., Ruddy, K. J., Santos, C., Saule, C., Scarpitta, R., Schmutzler, R. K., Schuster, H., Senter, L., Seynaeve, C. M., Shah, P. D., Sharma, P., Shin, V. Y., Silvestri, V., Simard, J., Singer, C. F., Skytte, A-B., Snape, K., Solano, A. R., Soucy, P., Southey, M. C., Spurdle, A. B., Steele, L., Steinemann, D., Stoppa-Lyonnet, D., Stradella, A., Sunde, L., Sutter, C., Tan, Y. Y., Teixeira, M. R., Teo, S. H., Thomassen, M., Tibiletti, M. G., Tischkowitz, M., Tognazzo, S., Toland, A. E., Tommasi, S., Torres, D., Toss, A., Trainer, A. H., Tung, N., van Asperen, C. J., van der Baan, F. H., van der Kolk, L. E., van der Luijt, R. B., van Hest, L. P., Varesco, L., Varon-Mateeva, R., Viel, A., Vierstraete, J., Villa, R., von Wachenfeldt, A., Wagner, P., Wang-Gohrke, S., Wappenschmidt, B., Weitzel, J. N., Wieme, G., Yadav, S., Yannoukakos, D., Yoon, S-Y., Zanzottera, C., Zorn, K. K., D'Amico, A. V., Freedman, M. L., Pomerantz, M. M., Chenevix-Trench, G., Antoniou, A. C., Neuhausen, S. L., Ottini, L., Nielsen, H. R. & Rebbeck, T. R., 13. Nov 2019, In : Cancer research.

Research output: Contribution to journalJournal articleResearchpeer-review

Prostatic Neoplasms
Prostate Cancer, Hereditary, 7
Genetic Association Studies

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3

Block, I., Müller, C., Sdogati, D., Pedersen, H., List, M., Jaskot, A. M., Syse, S. D., Lund Hansen, P., Schmidt, S., Christiansen, H., Casella, C., Bering Olsen, S., Blomstrøm, M. M., Riedel, A., Thomassen, M., Kruse, T. A., Karlskov Hansen, S. W., Kioschis, P. & Mollenhauer, J., 6. Jun 2019, In : Oncogene. 38, 23, p. 4560-4573

Research output: Contribution to journalJournal articleResearchpeer-review

Properdin
Up-Regulation
Growth
Neoplasms
Mutation

Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia

Garabet, L., Ghanima, W., Monceyron Jonassen, C., Skov, V., Holst, R., Mowinckel, M-C., Hans, C. H., Torben, A. K., Thomassen, M., Liebman, H., Bussel, J. B. & Sandset, P. M., 17. Feb 2019, In : Platelets. 30, 2, p. 206-212

Research output: Contribution to journalJournal articleResearchpeer-review

Thrombopoietin Receptors
P-Selectin
Idiopathic Thrombocytopenic Purpura
Plasminogen Activator Inhibitor 1
Platelet Count

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

Jacobsen, V. M., Li, S., Wang, A., Zhu, D., Liu, M., Thomassen, M., Kruse, T. A. & Tan, Q., 3. Aug 2019, In : Gynecological Endocrinology. 35, 8, p. 691-694

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Epigenomics
DNA Methylation
HLA-G Antigens
Chromosomes, Human, Pair 19

Evaluation of tumor-infiltrating lymphocytes and association with prognosis in BRCA-mutated breast cancer

Sønderstrup, I. M. H., Jensen, M. B., Ejlertsen, B., Eriksen, J. O., Gerdes, A. M., Kruse, T. A., Larsen, M. J., Thomassen, M. & Laenkholm, A. V., 4. Mar 2019, In : Acta Oncologica. 58, 3, p. 363-370

Research output: Contribution to journalJournal articleResearchpeer-review

Tumor-Infiltrating Lymphocytes
Mutation
Germ-Line Mutation
Risk Reduction Behavior
Paraffin
49 Downloads (Pure)

FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: Today, Tomorrow, and Beyond

Centre for Personalized Response Monitoring in Oncology (PREMIO), 15. Aug 2019, In : Cancers . 11, 8, 13 p., 1190.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Disease-Free Survival
Prospective Studies
Guidelines
Response Evaluation Criteria in Solid Tumors
63 Downloads (Pure)

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

EMBRACE Collaborators, 15. Apr 2019, In : Nature Communications. 10, 18 p., 1741.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
genome
Genome-Wide Association Study
loci
Transcriptome
breast

Genomic Profiling of a Phase III Clinical Trial of Interferon Versus Hydroxyurea in MPN Patients Reveals Mutation-Specific and Treatment-Specific Patterns of Response

Knudsen, T. A., Skov, V., Werner, L., Duke, W., Gibson, C. J., Nag, A., Thorner, A. R., Wollison, B., Lund Hansen, D., Larsen, T. S., Ellervik, C., El Fassi, D., de Stricker, K., Ocias, L. F., Brabrand, M., Weiss Bjerrum, O., Overgaard, U. M., Frederiksen, M., Kielsgaard Kristensen, T., Kruse, T. A. & 11 others, Thomassen, M., Mourits-Andersen, T., Severinsen, M. T., Jesper, S., Starklint, J., Møller, P., Neuberg, D. S., Kjær, L., Hasselbalch, H. C., Coleman Lindsley, R. & Mullally, A., 9. Dec 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Genomic Profiling of a Phase III Clinical Trial of Interferon Versus Hydroxyurea in MPN Patients Reveals Mutation-Specific and Treatment-Specific Patterns of Response

Knudsen, T. A., Skov, V., Werner, L., Duke, W., Gibson, C. J., Nag, A., Thorner, A. R., Wollison, B., Lund Hansen, D., Larsen, T. S., Ellervik, C., El Fassi, D., de Stricker, K., Ocias, L. F., Brabrand, M., Weiss Bjerrum, O., Overgaard, U. M., Frederiksen, M., Kielsgaard Kristensen, T., Kruse, T. A. & 11 others, Thomassen, M., Mourits-Andersen, H. T., Severinsen, M. T., Jesper, S., Starklint, J., Møller, P., Neuberg, D. S., Kjær, L., Hasselbalch, H. C., Coleman Lindsley, R. & Mullally, A., 13. Nov 2019, In : Blood. 134, Supplement 1, 4202.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Genomisk medicin og kunstig intelligens

Translated title of the contribution: Genomic medicine and artificial intelligenceKruse, T. A., Larsen, M. J., Tan, Q., Andersen, L. & Thomassen, M., 1. Apr 2019, In : Ugeskrift for Laeger. 181, 7A, V02190085.

Research output: Contribution to journalJournal articleResearchpeer-review

Medicine
Datasets
Clinical Decision-Making

Global expression profiling of cognitive level and decline in middle-aged monozygotic twins

Nygaard, M., Larsen, M. J., Thomassen, M., McGue, M., Christensen, K., Tan, Q. & Christiansen, L., Dec 2019, In : Neurobiology of Aging. 84, p. 141-147

Research output: Contribution to journalJournal articleResearchpeer-review

Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

Thomassen, M. & GEMO Study Collaborators, 1. Apr 2019, In : National Cancer Institute. Journal (Print). 111, 4, p. 350-364

Research output: Contribution to journalJournal articleResearchpeer-review

Random Allocation
Body Mass Index
Mutation
Confidence Intervals
Proportional Hazards Models

IMPACT OF SMOKING ON JAK2V617F ALLELE BURDEN AMONG PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS TREATED WITH PEGYLATED INTERFERON ALPHA-2 OR HYDROXYUREA IN THE DALIAH TRIAL

Andersen Patel, D., Knudsen, T. A., Lund Hansen, D., Ocias, L. F., Weiss Bjerrum, O., Brabrand, M., Ellervik, C., el Fassi, D., Frederiksen, M., Kjær, L., Kielsgaard Kristensen, T., Kruse, T., Mourits-Andersen, H. T., Møller, P., Overgaard, U. M., Severinsen, M. T., Skov, V., Lindholm Sørensen, A., Jesper, S., Starklint, J. & 4 others, de Stricker, K., Thomassen, M., Larsen, T. S. & Hasselbalch, H. C., Jun 2019, In : HemaSphere. 2019, PB2210.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Lautrup, C. K. & kConFab Investigators, Sep 2019, In : Human Mutation. 40, 9, p. 1557-1578

Research output: Contribution to journalJournal articleResearchpeer-review

Virulence
Computational Biology
Pathology
Messenger RNA
Research

Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

kConFab Investigators, 19. Jun 2019, In : British Journal of Cancer. 121, 2, p. 180–192

Research output: Contribution to journalJournal articleResearchpeer-review

Random Allocation
Ovarian Neoplasms
Body Mass Index
Mutation
Confidence Intervals
96 Downloads (Pure)

MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification

Eskildsen, T. V., Ayoubi, S., Thomassen, M., Burton, M., Mandegar, M. A., Conklin, B. R., Jensen, C. H., Andersen, D. C. & Sheikh, S. P., Jan 2019, In : Developmental Biology. 445, 1, p. 1-7

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Primitive Streak
Cell Differentiation
Mesoderm
Messenger RNA

Molecular profiling reveals highly de-regulated insulin growth factor binding proteins in patients with myelofibrosis and related neoplasms

Skov, V., Thomassen, M., Kjær, L., Riley, C. H., Larsen, T. S., Weiss Bjerrum, O., Kruse, T. A. & Hasselbalch, H. C., 14. Jun 2019.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

11 Downloads (Pure)

Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Elkjaer, M. L., Frisch, T., Reynolds, R., Kacprowski, T., Burton, M., Kruse, T. A., Thomassen, M., Baumbach, J. & Illes, Z., 11. Dec 2019, In : Acta Neuropathologica Communications. 7, 17 p., 205.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Endophenotypes
Heat-Shock Response
White Matter
Heat-Shock Proteins

Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease

The Danish IBD Genetics Working Group, Apr 2019, In : Alimentary Pharmacology and Therapeutics. 49, 7, p. 890-903

Research output: Contribution to journalJournal articleResearchpeer-review

Interleukin-18
Inflammatory Bowel Diseases
Ulcerative Colitis
Tumor Necrosis Factor-alpha
Crohn Disease
106 Downloads (Pure)

Shared heritability and functional enrichment across six solid cancers

Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C. & 313 others, Antonenkova, N. N., Arnold, S. M., Aronson, K. J., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Batra, J., Beckmann, M. W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S. I., Bickeböller, H., Bien, S. A., Blomqvist, C., Boccia, S., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Brauch, H., Brenner, H., Brenton, J. D., Brook, M. N., Brunet, J., Brunnström, H., Buchanan, D. D., Burwinkel, B., Butzow, R., Cadoni, G., Caldés, T., Caligo, M. A., Campbell, I., Campbell, P. T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A. L., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chen, C., Christiani, D. C., Claes, K. B. M., Claessens, F., Clements, J., Collée, J. M., Correa, M. C., Couch, F. J., Cox, A., Cunningham, J. M., Cybulski, C., Czene, K., Daly, M. B., deFazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J. L., Dörk, T., Duell, E. J., Dunning, A. M., Dwek, M., Eccles, D. M., Edlund, C. K., Edwards, D. R. V., Ellberg, C., Evans, D. G., Fasching, P. A., Ferris, R. L., Liloglou, T., Figueiredo, J. C., Fletcher, O., Fortner, R. T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S. J., Ganz, P. A., Garber, J., García-Sáenz, J. A., Gayther, S. A., Giles, G. G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., Goode, E. L., Goodman, M. T., Goodman, G., Grankvist, K., Greene, M. H., Gronberg, H., Gronwald, J., Guénel, P., Håkansson, N., Hall, P., Hamann, U., Hamdy, F. C., Hamilton, R. J., Hampe, J., Haugen, A., Heitz, F., Herrero, R., Hillemanns, P., Hoffmeister, M., Høgdall, E., Hong, Y-C., Hopper, J. L., Houlston, R., Hulick, P. J., Hunter, D. J., Huntsman, D. G., Idos, G., Imyanitov, E. N., Ingles, S. A., Isaacs, C., Jakubowska, A., James, P., Jenkins, M. A., Johansson, M., Johansson, M., John, E. M., Joshi, A. D., Kaneva, R., Karlan, B. Y., Kelemen, L. E., Kühl, T., Khaw, K-T., Khusnutdinova, E., Kibel, A. S., Kiemeney, L. A., Kim, J., Kjaer, S. K., Knight, J. A., Kogevinas, M., Kote-Jarai, Z., Koutros, S., Kristensen, V. N., Kupryjanczyk, J., Lacko, M., Lam, S., Lambrechts, D., Landi, M. T., Lazarus, P., Le, N. D., Lee, E., Lejbkowicz, F., Lenz, H-J., Leslie, G., Lessel, D., Lester, J., Levine, D. A., Li, L., Li, C. I., Lindblom, A., Lindor, N. M., Liu, G., Loupakis, F., Lubiński, J., Maehle, L., Maier, C., Mannermaa, A., Marchand, L. L., Margolin, S., May, T., McGuffog, L., Meindl, A., Middha, P., Miller, A., Milne, R. L., MacInnis, R. J., Modugno, F., Montagna, M., Moreno, V., Moysich, K. B., Mucci, L., Muir, K., Mulligan, A. M., Nathanson, K. L., Neal, D. E., Ness, A. R., Neuhausen, S. L., Nevanlinna, H., Newcomb, P. A., Newcomb, L. F., Nielsen, F. C., Nikitina-Zake, L., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olama, A. A. A., Olopade, O. I., Olshan, A. F., Olsson, H., Osorio, A., Pandha, H., Park, J. Y., Pashayan, N., Parsons, M. T., Pejovic, T., Penney, K. L., Peters, W. H. M., Phelan, C. M., Phipps, A. I., Plaseska-Karanfilska, D., Pring, M., Prokofyeva, D., Radice, P., Stefansson, K., Ramus, S. J., Raskin, L., Rennert, G., Rennert, H. S., van Rensburg, E. J., Riggan, M. J., Risch, H. A., Risch, A., Roobol, M. J., Rosenstein, B. S., Rossing, M. A., De Ruyck, K., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schabath, M. B., Schleutker, J., Schmidt, M. K., Setiawan, V. W., Shen, H., Siegel, E. M., Sieh, W., Singer, C. F., Slattery, M. L., Sorensen, K. D., Southey, M. C., Spurdle, A. B., Stanford, J. L., Stevens, V. L., Stintzing, S., Stone, J., Sundfeldt, K., Sutphen, R., Swerdlow, A. J., Tajara, E. H., Tangen, C. M., Tardon, A., Taylor, J. A., Teare, M. D., Teixeira, M. R., Terry, M. B., Terry, K. L., Thibodeau, S. N., Thomassen, M., Bjørge, L., Tischkowitz, M., Toland, A. E., Torres, D., Townsend, P. A., Travis, R. C., Tung, N., Tworoger, S. S., Ulrich, C. M., Usmani, N., Vachon, C. M., Van Nieuwenhuysen, E., Vega, A., Aguado-Barrera, M. E., Wang, Q., Webb, P. M., Weinberg, C. R., Weinstein, S., Weissler, M. C., Weitzel, J. N., West, C. M. L., White, E., Whittemore, A. S., Wichmann, H-E., Wiklund, F., Winqvist, R., Wolk, A., Woll, P., Woods, M., Wu, A. H., Wu, X., Yannoukakos, D., Zheng, W., Zienolddiny, S., Ziogas, A., Zorn, K. K., Lane, J. M., Saxena, R., Thomas, D., Hung, R. J., Diergaarde, B., McKay, J., Peters, U., Hsu, L., García-Closas, M., Eeles, R. A., Chenevix-Trench, G., Brennan, P. J., Haiman, C. A., Simard, J., Easton, D. F., Gruber, S. B., Pharoah, P. D. P., Price, A. L., Pasaniuc, B., Amos, C. I., Kraft, P. & Lindström, S., 25. Jan 2019, In : Nature Communications. 10, 1, p. 1-23 431.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
cancer
Nucleic Acid Regulatory Sequences
Tumors
Neoplasms
Genes
31 Downloads (Pure)

Subtypes in BRCA-mutated breast cancer

Sønderstrup, I., Jensen, M. B., Ejlertsen, B., Eriksen, J. O., Gerdes, A. M., Kruse, T. A., Larsen, M. J., Thomassen, M. & Lænkholm, A. V., 1. Feb 2019, In : Human Pathology. 84, p. 192-201

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Germ Cells
Germ-Line Mutation
Neoplasms
Hormones
Breast Cancer 3
18 Downloads (Pure)

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Bojesen, S. E., Flyger, H., Nielsen, F. C., Rossing, M. & ABCTB Investigators, Nov 2019, In : n p j Breast Cancer. 5, 14 p., 38.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Chromosome Fragility
BRCA2 Gene
BRCA1 Gene
Cell Survival
Fibroblasts

The Optimal Sequencing Depth of Tumor Biopsies for Identifying Clonal Cell Populations

Tabatabaeifar, S., Larsen, M. J., Thomassen, M., Larsen, S. R., Kruse, T. A. & Sørensen, J. A., 1. Sep 2019, In : Journal of Molecular Diagnostics. 21, 5, p. 790-795

Research output: Contribution to journalJournal articleResearchpeer-review

Population
Neoplasms
Research Personnel
DNA Sequence Analysis
Cluster Analysis
DNA
Neoplasms
Mutation
Residual Neoplasm
2018

A Danish national effort of BRCA1/2 variant classification

Pedersen, I. S., Schmidt, A. Y., Bertelsen, B., Ernst, A., Andersen, C. L. T., Kruse, T., Rossing, M. & Thomassen, M., 2. Jan 2018, In : Acta Oncologica. 57, 1, p. 159-162

Research output: Contribution to journalComment/debateResearchpeer-review

132 Downloads (Pure)

Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer

Block, I., Burton, M., Sørensen, K. P., Andersen, L., Larsen, M. J., Bak, M., Cold, S., Thomassen, M., Tan, Q. & Kruse, T. A., 6. Feb 2018, In : OncoTarget. 9, 10, p. 9030-9042

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
42 Downloads (Pure)

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Lu, Y., Beeghly-Fadiel, A., Wu, L., Guo, X., Li, B., Schildkraut, J. M., Im, H. K., Chen, Y. A., Permuth, J. B., Reid, B. M., Teer, J. K., Moysich, K. B., Andrulis, I. L., Anton-Culver, H., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Benitez, J., Bjorge, L. & 124 others, Brenton, J., Butzow, R., Caldes, T., Caligo, M. A., Campbell, I., Chang-Claude, J., Claes, K. B. M., Couch, F. J., Cramer, D. W., Daly, M. B., deFazio, A., Dennis, J., Diez, O., Domchek, S. M., Dörk, T., Easton, D. F., Eccles, D. M., Fasching, P. A., Fortner, R. T., Fountzilas, G., Friedman, E., Ganz, P. A., Garber, J., Giles, G. G., Godwin, A. K., Goldgar, D. E., Goodman, M. T., Greene, M. H., Gronwald, J., Hamann, U., Heitz, F., Hildebrandt, M. A. T., Høgdall, C. K., Hollestelle, A., Hulick, P. J., Huntsman, D. G., Imyanitov, E. N., Isaacs, C., Jakubowska, A., James, P., Karlan, B. Y., Kelemen, L. E., Kiemeney, L. A., Kjaer, S. K., Kwong, A., Le, N. D., Leslie, G., Lesueur, F., Levine, D. A., Mattiello, A., May, T., McGuffog, L., McNeish, I. A., Merritt, M. A., Modugno, F., Montagna, M., Neuhausen, S. L., Nevanlinna, H., Nielsen, F. C., Nikitina-Zake, L., Nussbaum, R. L., Offit, K., Olah, E., Olopade, O. I., Olson, S. H., Olsson, H., Osorio, A., Park, S. K., Parsons, M. T., Peeters, P. H. M., Pejovic, T., Peterlongo, P., Phelan, C. M., Pujana, M. A., Ramus, S. J., Rennert, G., Risch, H., Rodriguez, G. C., Rodríguez-Antona, C., Romieu, I., Rookus, M. A., Rossing, M. A., Rzepecka, I. K., Sandler, D. P., Schmutzler, R. K., Setiawan, V. W., Sharma, P., Sieh, W., Simard, J., Singer, C. F., Song, H., Southey, M. C., Spurdle, A. B., Sutphen, R., Swerdlow, A. J., Teixeira, M. R., Teo, S. H., Thomassen, M., Tischkowitz, M., Toland, A. E., Trichopoulou, A., Tung, N., Tworoger, S. S., van Rensburg, E. J., Vanderstichele, A., Vega, A., Edwards, D. V., Webb, P. M., Weitzel, J. N., Wentzensen, N., White, E., Wolk, A., Wu, A. H., Yannoukakos, D., Zorn, K. K., Gayther, S. A., Antoniou, A. C., Berchuck, A., Goode, E. L., Chenevix-Trench, G., Sellers, T. A., Pharoah, P. D. P., Zheng, W. & Long, J., 15. Sep 2018, In : Cancer Research. 78, 18, p. 5419-5430

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Transcriptome
Genome-Wide Association Study
RNA Sequence Analysis

Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG

Soenderstrup, I. M. H., Laenkholm, A. V., Jensen, M. B., Eriksen, J. O., Gerdes, A. M., Hansen, T. V. O., Kruse, T. A., Larsen, M. J., Pedersen, I. S., Rossing, M., Thomassen, M. & Ejlertsen, B., Jan 2018, In : Acta Oncologica. 57, 1, p. 95-101

Research output: Contribution to journalConference articleResearchpeer-review

Disease-Free Survival
Neoplasms
Mutation
Proportional Hazards Models
Paraffin
100 Downloads (Pure)

Differential effect of surgical manipulation on gene expression in normal breast tissue and breast tumor tissue

Pedersen, I. S., Thomassen, M., Tan, Q., Kruse, T. A., Thorlacius-Ussing, O., Garne, J. P. & Krarup, H. B., 16. Nov 2018, In : Molecular Medicine. 24, 8 p., 57.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Gene Expression Profiling
Transcriptome
Freezing
83 Downloads (Pure)

Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer

French COVAR group collaborators, 3. Apr 2018, In : Oncotarget. 9, 25, p. 17334-17348

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ovarian Neoplasms
BRCA2 Gene
France
Virulence
BRCA1 Gene
119 Downloads (Pure)

Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression

Krøigård, A. B., Larsen, M. J., Lænkholm, A-V., Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Thomassen, M. & Kruse, T. A., 1. Jan 2018, In : PLOS ONE. 13, 1, 18 p., e0189887.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
metastasis
breast neoplasms
Genes
neoplasms
genes
45 Downloads (Pure)

Interim analysis of the Daliah trial - a randomized controlled phase iii clinical trial Comparing recombinant interferon alpha-2 vs. Hydroxyurea in MPN patients.

Knudsen, T. A., Lund Hansen, D., Ocias, L. F., Weiss Bjerrum, O., Brabrand, M., El Fassi, D., Frederiksen, M., Kjær, L., Kielsgaard Kristensen, T., Kruse, T. A., Mourits-Andersen, H. T., Møller, P., Overgaard, U. M., Severinsen, M. T., Skov, V. H., Stentoft, J., Starklint, J., de Stricker, K., Thomassen, M., Larsen, T. S. & 1 others, Hasselbalch, H. C., 15. Jun 2018, In : HemaSphere. 2, S1, p. 18-19 S131.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
File
82 Downloads (Pure)

Lecocytes mutation load declines with age in carriers of the m.3243A>G mutation: A 10-year Prospective Cohort

Langdahl, J. H., Larsen, M., Frost, M., Andersen, P. H., Yderstraede, K. B., Vissing, J., Dunø, M., Thomassen, M. & Frederiksen, A. L., Apr 2018, In : Clinical Genetics. 93, 4, p. 925-928

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
antineoplaston A10
Mutation
Longitudinal Studies

Molecular heterogeneity of mantle cell lymphoma

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 4. May 2018.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

143 Downloads (Pure)

Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations

Rebbeck, T. R., Friebel, T. M., Friedman, E., Hamann, U., Huo, D., Kwong, A., Olah, E., Olopade, O. I., Solano, A. R., Teo, S-H., Thomassen, M., Weitzel, J. N., Chan, T. L., Couch, F. J., Goldgar, D. E., Kruse, T. A., Palmero, E. I., Park, S. K., Torres, D., van Rensburg, E. J. & 31 others, McGuffog, L., Parsons, M. T., Leslie, G., Aalfs, C. M., Abugattas, J., Adlard, J., Agata, S., Aittomäki, K., Andrews, L., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Asseryanis, E., Auerbach, L., Azzollini, J., Balmaña, J., Barile, M., Barkardottir, R. B., Barrowdale, D., Benitez, J., Berger, A., Berger, R., Blanco, A. M., Blazer, K. R., Blok, M. J., Bonadona, V., Gerdes, A-M., Nielsen, H. R., Skytte, A-B. & EMBRACE, May 2018, In : Human Mutation. 39, 5, p. 593-620

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Mutation
Population
Research Personnel
Germ-Line Mutation
Mutation Rate

Myeloproliferative Neoplasms in Danish Twins

Andersen, M. A., Bjerrum, O. W., Ranjan, A., Skov, V., Kruse, T. A., Thomassen, M., Skytthe, A., Hasselbalch, H. C. & Christensen, K., 3. May 2018, In : Acta Haematologica. 139, 3, p. 195-198

Research output: Contribution to journalJournal articleResearchpeer-review

Neoplasms
Monozygotic Twins
Registries
Dizygotic Twins
Cell Lineage

NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. Jun 2018.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. Jun 2018, In : EHA Learning Center. 2018, PB2322.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

56 Downloads (Pure)

Publisher Correction: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3)

Nielsen, H. M., Andersen, C. L., Westman, M., Kristensen, L. S., Asmar, F., Kruse, T. A., Thomassen, M., Larsen, T. S., Skov, V., Hansen, L. L., Bjerrum, O. W., Hasselbalch, H. C., Punj, V. & Grønbæk, K., 20. Nov 2018, In : Scientific Reports. 8, 1 p., 17311.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
File
Epigenomics
Mutation

SAFETY AND EFFICACY OF COMBINATION THERAPY OF INTERFERON ΑLPHA-2 AND RUXOLITINIB IN POLYCYTHEMIA VERA AND LOW-/INTERMEDIATE-1-RISK MYELOFIBROSIS – A ONE YEAR FOLLOW-UP UPDATE OF A PHASE II STUDY

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Skov, V., Andersen, C. B. L., Weiss Bjerrum, O., Brochmann Mortensen, N., El Fassi, D., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M. & Hasselbalch, H. C., Jun 2018, In : EHA Learning Center. 2018, PF620.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

136 Downloads (Pure)

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Andersen, C. B. L., Bjerrum, O. W., Brochmann, N., Fassi, D. E., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M., Skov, V. & Hasselbalch, H. C., 1. Aug 2018, In : Cancer Medicine. 7, 8, p. 3571-3581

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycythemia Vera
Safety
INCB018424
Neoplasms
Alleles

Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

Kjaer, L., Holmström, M. O., Cordua, S., Andersen, M. H., Svane, I. M., Thomassen, M., Kruse, T. A., Pallisgaard, N., Skov, V. & Hasselbalch, H. C., Apr 2018, In : Leukemia and Lymphoma. 59, 4, p. 973-977

Research output: Contribution to journalComment/debateCommunication

The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium

Moghadasi, S., Meeks, H. D., Vreeswijk, M. P., Janssen, L. A., Borg, Å., Ehrencrona, H., Paulsson-Karlsson, Y., Wappenschmidt, B., Engel, C., Gehrig, A., Arnold, N., Hansen, T. V. O., Thomassen, M., Jensen, U. B., Kruse, T. A., Ejlertsen, B., Gerdes, A-M., Pedersen, I. S., Caputo, S. M., Couch, F. & 20 others, Hallberg, E. J., van den Ouweland, A. M., Collée, M. J., Teugels, E., Adank, M. A., van der Luijt, R. B., Mensenkamp, A. R., Oosterwijk, J. C., Blok, M. J., Janin, N., Claes, K. B., Tucker, K., Viassolo, V., Toland, A. E., Eccles, D. E., Devilee, P., Van Asperen, C. J., Spurdle, A. B., Goldgar, D. E. & Garcia, E. B. G., Jan 2018, In : Journal of Medical Genetics. 55, 1, p. 15-20

Research output: Contribution to journalLetterResearchpeer-review

Ovarian Neoplasms
Alleles
Neoplasms
Ovariectomy
81 Downloads (Pure)

Whole Blood Gene Expression Profiling in patients undergoing colon cancer surgery identifies differential expression of genes involved in immune surveillance, inflammation and carcinogenesis

Watt, S. K., Hasselbalch, H. C., Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M. & Gögenur, I., Jun 2018, In : Surgical Oncology. 27, 2, p. 208-215

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Gene Expression Profiling
Colonic Neoplasms
Ambulatory Surgical Procedures
Down-Regulation
Chemical Databases
2017
119 Downloads (Pure)

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Hamdi, Y., Soucy, P., Kuchenbaeker, K. B., Pastinen, T., Droit, A., Lemaçon, A., Adlard, J., Aittomäki, K., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Azzollini, J., Bane, A., Barjhoux, L., Barrowdale, D., Benítez, J., Berthet, P., Blok, M. J., Bobolis, K. A. & 31 others, Bonadona, V., Bonanni, B., Bradbury, A. R., Brewer, C., Buecher, B., Buys, S., Caligo, M. A., Chiquette, J., Chung, W. K., Claes, K. B. M., Daly, M. B., Damiola, F., Davidson, R., de la Hoya, M., De Leeneer, K., Díez, O., Ding, Y. C., Dolcetti, R., Domchek, S. M., Dorfling, C. M., Eccles, D., Eeles, R., Einbeigi, Z., Ejlertsen, B., Engel, C., Gareth Evans, D., Feliubadaló, L., Foretova, L., Gerdes, A-M., Thomassen, M. & EMBRACE, 2017, In : Breast Cancer Research and Treatment. 161, 1, p. 117-134

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Heterozygote
Single Nucleotide Polymorphism
Mutation
Quantitative Trait Loci
Progesterone Receptors

Clinical outcomes of female breast cancer according to BRCA mutation status

Cronin-Fenton, D. P., Kjaersgaard, A., Norgaard, M., Pedersen, I. S., Thomassen, M., Kaye, J. A., Gutierrez, L., Telford, C., Lewis, J., Tyczynski, J. E. & Sorensen, H. T., Aug 2017, In : Cancer Epidemiology. 49, p. 128-137

Research output: Contribution to journalJournal articleResearchpeer-review

Mutation
Germ-Line Mutation
Denmark
Selection Bias
Incidence
177 Downloads (Pure)

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Li, S., Zhu, D., Duan, H., Ren, A., Glintborg, D., Andersen, M., Skov, V., Thomassen, M., Kruse, T. & Tan, Q., 1. Jan 2017, In : Oncotarget. 8, 13, p. 20656-20666

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycystic Ovary Syndrome
DNA Methylation
Epigenomics
Prolactin
DNA
134 Downloads (Pure)

Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

Myrtue Nielsen, H., Lykkegaard Andersen, C., Westman, M., Sommer Kristensen, L., Asmar, F., Kruse, T. A., Thomassen, M., Stauffer Larsen, T., Skov, V., Lotte Hansen, L., Weis Bjerrum, O., Carl Hasselbalch, H., Punj, V. & Grønbæk, K., 2017, In : Scientific Reports. 7, 11 p., 6774.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epigenomics
Mutation
DNA Methylation
Histones
Nucleic Acid Regulatory Sequences
132 Downloads (Pure)
Open Access
File
Cluster Analysis
Health