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  • Jesper Wengel
2015

Detection and discrimination of biofilm populations using locked nucleic acid/2'-O-methyl-RNA fluorescence in situ hybridization (LNA/2'OMe-FISH)

Azevedo, A. S., Almeida, C., Pereira, B., Madureira, P., Wengel, J. & Azevedo, N. F., 2015, In : Biochemical Engineering Journal. 104, 15 December, p. 64-73 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Santos, R. S., Dakwar, G. R., Xiong, R., Forier, K., Remaut, K., Stremersch, S., Guimarães, N., Fontenete, S., Wengel, J., Leite, M., Figueiredo, C., De Smedt, S. C., Braeckmans, K. & Azevedo, N. F., 10. Dec 2015, In : Molecular Therapy - Nucleic Acids. 4, p. e269 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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168 Downloads (Pure)

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids

Fontenete, S., Joana, B., Pedro, M., Céu, F., Wengel, J. & Filipe, A. N., May 2015, In : Applied Microbiology and Biotechnology. 99, 9, p. 3961-3969

Research output: Contribution to journalJournal articleResearchpeer-review

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

Opazo, F., Eiden, L., Hansen, L., Rohrbach, F., Wengel, J., Kjems, J. & Mayer, G., 2015, In : Molecular Therapy - Nucleic Acids. 4, 10 p., e251.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
200 Downloads (Pure)

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance

Lou, C., Vester, B. & Wengel, J., 9. Feb 2015, In : Chemical Communications. 51, 19, p. 4024-4027

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
193 Downloads (Pure)

Selection of LNA-containing DNA aptamers against recombinant human CD73

Elle, I. C., Karlsen, K. K., Terp, M. G., Larsen, N., Nielsen, R., Derbyshire, N., Mandrup, S., Ditzel, H. J. & Wengel, J., 21. Apr 2015, In : Molecular BioSystems. 11, 5, p. 1260-1270

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
243 Downloads (Pure)

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

Edwards, S. L., Poongavanam, V., R Kanwar, J., Roy, K., M. Hillman, K., Prasad, N., Leth-Larsen, R., Petersen, M., Marusic, M., Plavec, J., Wengel, J. & Veedu, R. N., 7. May 2015, In : Chemical Communications. 51, 46, p. 9499-9502

Research output: Contribution to journalJournal articleResearchpeer-review

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

Fontenete, S., Leite, M., Guimarães, N., Madureira, P., Ferreira, R. M., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2015, In : PLOS ONE. 10, 4, p. e0125494 22 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
382 Downloads (Pure)

Watson-Crick hydrogen bonding of unlocked nucleic acids

Langkjær, N., Wengel, J. & Pasternak, A., 15. Nov 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 22, p. 5064-6 3 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2016

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

Bienk, K., Hvam, M. L., Pakula, M. M., Dagnæs-Hansen, F., Wengel, J., Malle, B. M., Kragh-Hansen, U., Cameron, J., Bukrinski, J. T. & Howard, K. A., 2016, In : Journal of Controlled Release. 232, p. 143-151

Research output: Contribution to journalJournal articleResearchpeer-review

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

Fontenete, S., Carvalho, D. R., Guimarães, N., Madureira, P., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2016, In : Applied Microbiology and Biotechnology. 100, 13, p. 5897-5906

Research output: Contribution to journalJournal articleResearchpeer-review

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs

Gissberg, O., Zaghloul, E. M., Lundin, K. E., Nguyen, C-H., Landras-Guetta, C., Wengel, J., Zain, R. & Smith, C. I. E., 2016, In : Nucleic Acid Therapeutics. 26, 3, p. 183-189

Research output: Contribution to journalLetterResearchpeer-review

Evaluation of nucleolin and somatostatin receptor targeting for therapeutic delivery to lung cancer stem cells

Hansen, P. L., Holmboe, S., Olsen, B. B., Thisgaard, H., Christiansen, H., Schmidt, S., Block, I., Müller, C., Langkjær, N., Jørgensen, P. T., Vogel, S., Wengel, J., Høilund-Carlsen, P. F. & Mollenhauer, J., 27. Jun 2016.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

Fontenete, S., Leite, M., Cappoen, D., Santos, R., Ginneken, C. V., Figueiredo, C., Wengel, J., Cos, P. & Azevedo, N. F., 2016, In : P L o S One. 11, 2, 18 p., e0148353.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
327 Downloads (Pure)

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Geny, S., Moreno, P. M. D., Krzywkowski, T., Gissberg, O., Andersen, N. K., Isse, A. J., El-Madani, A. M., Lou, C., Pabon, Y. V., Anderson, B. A., Zaghloul, E. M., Zain, R., Hrdlicka, P. J., Jørgensen, P. T., Nilsson, M., Lundin, K. E., Pedersen, E. B., Wengel, J. & Smith, C. I. E., 18. Mar 2016, In : Nucleic Acids Research. 44, 5, p. 2007-2019

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
355 Downloads (Pure)

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J., 2016, In : Nature Communications. 7, p. 1-9 12294.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
209 Downloads (Pure)

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models

Fontenete, S., Guimarães, N., Wengel, J. & Azevedo, N. F., 2016, In : Critical Reviews in Biotechnology. 36, 3, p. 566-577

Research output: Contribution to journalReviewResearchpeer-review

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2'-Amino-LNA Monomers

Ries, A., Kumar, R., Lou, C., Kosbar, T., Vengut-Climent, E., Jørgensen, P. T., Morales, J. C. & Wengel, J., 13. Oct 2016, In : The Journal of Organic Chemistry. 81, 22, p. 10845-10856

Research output: Contribution to journalJournal articleResearchpeer-review

2017

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes

Ejlersen, M., Langkjær, N. & Wengel, J., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2073-2085

Research output: Contribution to journalJournal articleResearchpeer-review

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Cai, Y., López-Ruiz, E., Wengel, J., Creemers, L. B. & Howard, K. A., 2017, In : Journal of controlled release : official journal of the Controlled Release Society. 253, p. 153-159

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
188 Downloads (Pure)

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J. S., Sohn, E., Bienk, K., Schaffert, D., Sørensen, E. S., Wengel, J., Dupont, D. M. & Howard, K. A., 2017, In : Molecular Therapy - Nucleic Acids. 9, p. 284-293

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
185 Downloads (Pure)

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Zaghloul, E. M., Gissberg, O., Moreno, P. M. D., Siggens, L., Hällbrink, M., Jørgensen, A. S., Ekwall, K., Zain, R., Wengel, J., Lundin, K. E. & Smith, C. I. E., 2017, In : Nucleic Acids Research. 45, 9, p. 5153-5169

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
329 Downloads (Pure)

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule

Aaldering, L. J., Poongavanam, V., Langkjær, N., Murugan, N. A., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2017, In : ChemBioChem. 18, 8, p. 755–763

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
186 Downloads (Pure)

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J. S., Wengel, J., Kjems, J. & Howard, K. A., 2017, In : Molecular Therapy. 25, 7, p. 1710-1717

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
150 Downloads (Pure)

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

Lou, C., Christensen, N. J., Martos-Maldonado, M. C., Midtgaard, S. R., Ejlersen, M., Thulstrup, P. W., Sørensen, K. K., Jensen, K. J. & Wengel, J., 2017, In : Chemistry: A European Journal. 23, 39, p. 9297–9305

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
169 Downloads (Pure)

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

Pabon-Martinez, Y. V., Xu, Y., Villa, A., Lundin, K. E., Geny, S., Nguyen, C-H., Pedersen, E. B., Jørgensen, P. T., Wengel, J., Nilsson, L., Smith, C. I. E. & Zain, R., 2017, In : Scientific Reports. 7, 1, 16 p., 11043.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
240 Downloads (Pure)

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

Kristensen, K. V., Paul, S., Kosbar, T., Wengel, J. & Caruthers, M. H., 2017, In : Bioorganic & Medicinal Chemistry Letters. 27, 14, p. 3173–3176

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
285 Downloads (Pure)

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA

Lou, C., Samuelsen, S. V., Christensen, N. J., Vester, B. & Wengel, J., 2017, In : Bioconjugate Chemistry. 28, 4, p. 1214-1220

Research output: Contribution to journalJournal articleResearchpeer-review

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

Hartono, Y. D., Pabon-Martinez, Y. V., Uyar, A., Wengel, J., Lundin, K. E., Zain, R., Smith, C. I. E., Nilsson, L. & Villa, A., 2017, In : ACS Omega. 2, 5, p. 2165-2177 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
263 Downloads (Pure)

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding

Schmøkel, J., Voldum, A., Tsakiridou, G., Kuhlmann, M., Cameron, J., Sørensen, E. S., Wengel, J. & Howard, K. A., 2017, In : Nanotechnology. 28, 20, 9 p., 204004.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units

Kumar, R., Ries, A. & Wengel, J., 2017, In : Molecules. 22, 5, 13 p., 852.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
206 Downloads (Pure)
2018

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

Garcia, J., Stein, J., Cai, Y., Wexselblatt, E., Creemers, L., Wengel, J., Howard, K., Saris, D. & Yayon, A., 1. Apr 2018, In : Osteoarthritis and Cartilage. 26, Suppl. 1, p. S145

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Moreno, P. M. D., Ferreira, A. R., Salvador, D., Rodrigues, M. T., Torrado, M., Carvalho, E. D., Tedebark, U., Sousa, M. M., Amaral, I. F., Wengel, J. & Pêgo, A. P., 2018, In : Molecular Therapy - Nucleic Acids. 11, p. 393-406

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
297 Downloads (Pure)

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J. & Xodo, L. E., 2018, In : RNA Biology. 15, 10, p. 1273-1285

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
158 Downloads (Pure)

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Ejlersen, M., Lou, C., Sanghvi, Y. S., Tor, Y. & Wengel, J., 12. Jul 2018, In : Chemical Communications. 54, 57, p. 8003-8006

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
113 Downloads (Pure)

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

Vejlegaard, K., Wegeberg, C., McKee, V. & Wengel, J., 2018, In : Organic & Biomolecular Chemistry. 16, 8, p. 1312-1321

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
147 Downloads (Pure)

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

Cai, Y., Makarova, A-M., Wengel, J. & Howard, K. A., 2018, In : Journal of Gene Medicine. 20, 7-8, p. 1-6

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
125 Downloads (Pure)

Peptide-Oligonucleotide Conjugates as Nanoscale Building Blocks

Boesen, J., Sorensen, K., Lou, C., Wengel, J. & Jensen, K. J., 1. Sep 2018, In : Journal of Peptide Science. 24, Suppl. 2, p. S157 1 p.

Research output: Contribution to journalConference abstract in journalResearch

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA

Ejlersen, M., Christensen, N. J., Sørensen, K. K., Jensen, K. J., Wengel, J. & Lou, C., 2018, In : Bioconjugate Chemistry. 29, 4, p. 1025–1029

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
134 Downloads (Pure)

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides

Lima, J. F., Carvalho, J., Pinto-Ribeiro, I., Almeida, C., Wengel, J., Cerqueira, L., Figueiredo, C., Oliveira, C. & Azevedo, N. F., 7. Jun 2018, In : BMC Molecular Biology. 19, 13 p., 6.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
142 Downloads (Pure)

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Kotkowiak, W., Lisowiec-Wachnicka, J., Grynda, J., Kierzek, R., Wengel, J. & Pasternak, A., 2018, In : Molecular Therapy - Nucleic Acids. 10, p. 304-316

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
119 Downloads (Pure)

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens

Le, B. T., Hughes, Q., Rakesh, S., Baker, R., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2018, In : RSC Advances. 8, 57, p. 32770-32774

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
142 Downloads (Pure)