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2010

A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes

Seefried, L., Mueller-Deubert, S., Wentzer, T. S., Lind, T., Mentrup, B., Kober, M., Docheva, D., Liedert, A., Kassem, M., Ignatius, A., Schieker, M., Claes, L., Wilke, W., Jakob, F. & Ebert, R., 1. Jan 2010, In : European Cells & Materials. 20, p. 344-55 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Polyurethanes
Bioreactors
Reporter Genes
Cell culture
Signal transduction

Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients

Diederichsen, A. C. P., Møller, J. E., Thayssen, P., Videbæk, L., Sækmose, S. G., Barington, T. & Kassem, M., 17. Mar 2010, In : Scandinavian Cardiovascular Journal. 44, 3, p. 139-145

Research output: Contribution to journalJournal articleResearchpeer-review

Plasma Volume
Brain Natriuretic Peptide
Outcome Assessment (Health Care)

Characterization of programmed death ligands in immune modulation of mesenchymal stem cells

Isa, A., Sabir, H. J., Nehlin, J., Andersen, T. E., Kassem, M. & Barington, T., 25. May 2010.

Research output: Contribution to conference without publisher/journalPosterResearch

Derivation and characterisation of hESC lines from supernumerary embryos, experience from Odense, Denmark

Harkness, L., Rasmussen, I. A., Erb, K. & Kassem, M., 2010, In : In Vitro Cellular & Developmental Biology - Animal. 46, 3-4, p. 259-268

Research output: Contribution to journalJournal articleResearchpeer-review

Denmark
Embryonic Structures
Cell Line
Polymerase Chain Reaction
Human Embryonic Stem Cells

Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/Activin/Nodal signaling using SB-431542

Mahmood, A., Harkness, L., Schrøder, H. D., Abdallah, B. & Kassem, M., 29. Jan 2010, In : Journal of Bone and Mineral Research. 25, 6, p. 1216-1223

Research output: Contribution to journalJournal articleResearchpeer-review

Inhibin-beta Subunits
Mesenchymal Stromal Cells
Up-Regulation
Regenerative Medicine
Desmin

Fibroblast growth factor 23 - et fosfatregulerende hormon

Translated title of the contribution: Fibroblast growth factor 23 - a phosphate regulating hormoneBeck-Nielsen, S., Pedersen, S. M., Kassem, M. & Rasmussen, L. M., 1. May 2010, In : Ugeskrift for læger. 172, 20, p. 1521-1527 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Hormones
Hypophosphatemia
Serum
Reference Values

Human mesenchymal stem cells: Basic bone biology and clinical applications for bone tissue regeneration

Kassem, M., Al-Nbaheen, M., Ali, D. & Al-Dahmash, A., 2010, Stem Cells: From Bench to Bedside. Bongso, A. & Lee, E. H. (eds.). 2 ed. World Scientific, p. 457-476 20 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells

Henriksen, J. M., Stabell, M., Meza-Zepeda, L. A., Lauvrak, S. A., Kassem, M. & Myklebost, O., 1. Jan 2010, In : B M C Cancer. 10, p. 329

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
Neoplasms
Proteins

Impaired cell surface expression of HLA-B antigens on mesenchymal stem cells and muscle cell progenitors

Isa, A., Nehlin, J., Sabir, H. J., Andersen, T., Gaster, M., Kassem, M. & Barington, T., 2010, In : P L o S One. 5, 5, p. e10900

Research output: Contribution to journalJournal articleResearchpeer-review

HLA-A Antigens
HLA-B Antigens
Stem cells
Mesenchymal Stromal Cells
myocytes

Interaction of human mesenchymal stem cells with osteopontin coated hydroxyapatite surfaces

Jensen, T., Dolatshahi-Pirouz, A., Foss, M., Baas, J., Lovmand, J., Duch, M., Pedersen, F. S., Kassem, M., Bünger, C., Søballe, K. & Besenbacher, F., 1. Jan 2010, In : Colloids and Surfaces B: Biointerfaces. 75, 1, p. 186-93 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Osteopontin
stem cells
Durapatite
Stem cells
Mesenchymal Stromal Cells

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

Sondergaard, B-C., Schultz, N., Madsen, S. H., Bay-Jensen, A-C., Kassem, M. & Karsdal, M. A., 1. Mar 2010, In : Osteoarthritis and Cartilage. 18, 3, p. 279-88 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cartilage
Matrix Metalloproteinases
Degradation
Chemical activation
Metalloproteases

Mechanosensitivity of dental pulp stem cells is related to their osteogenic maturity

Kraft, D. C. E., Bindslev, D. A., Melsen, B., Abdallah, B., Kassem, M. & Klein-Nulend, J., 1. Feb 2010, In : European Journal of Oral Sciences. 118, 1, p. 29-38 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Dental Pulp
Mesenchymal Stromal Cells
Pulsatile Flow
Osteogenesis
Osteocalcin
Stem cells
Mesenchymal Stromal Cells
Scaffolds
Bone
Collagen

Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin

Frost, M., Andersen, T. E., Yadav, V., Brixen, K., Karsenty, G. & Kassem, M., 29. Jan 2010, In : Journal of Bone and Mineral Research. 25, 3, p. 673-675 2 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mutation
Osteogenesis

Raman microscopy of individual living human embryonic stem cells

Novikov, S. M., Beermann, J., Bozhevolnyi, S. I., Harkness, L. & Kassem, M., 2010, In : Proceedings of SPIE. 7715, 771537.

Research output: Contribution to journalConference articleResearchpeer-review

Stem cells
Microscopic examination
Glass
Biomolecules
Substrates

Reparation af knogle og brusk med stamceller

Translated title of the contribution: [Bone and cartilage repair using stem cells]Larsen, K. H., Andersen, T. E. & Kassem, M., 20. Sep 2010, In : Ugeskrift for Laeger. 172, 38, p. 2616-9 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
Regenerative Medicine
Tissue Engineering
Chondrocytes
Osteoblasts

siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells

Andersen, M. Ø., Nygaard, J. V., Burns, J. S., Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J., 1. Nov 2010, In : Molecular Therapy. 18, 11, p. 2018-27

Research output: Contribution to journalJournal articleResearchpeer-review

Small Interfering RNA
Tissue Engineering
Mesenchymal Stromal Cells
Morphogenesis
RNA

Stemceller

Pørneki, A. D. S. & Kassem, M., 2010, In : Cardiologisk Forum. 15, 4, p. 21-23 2 p.

Research output: Contribution to journalJournal articleCommunication

Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal stem cell through canonical Wnt signaling and C/EBP

Qiu, W., Hu, Y., Andersen, T. E., Jafari Kermani, A., Li, N., Chen, W. & Kassem, M., 2010, In : Journal of Biological Chemistry. 285, p. 14438-14449

Research output: Contribution to journalJournal articleResearchpeer-review

2011
Wnt Signaling Pathway
MAP Kinase Signaling System
Stem cells
Mesenchymal Stromal Cells
Bone

Bone regeneration and stem cells

Arvidson, K., Abdallah, B. M., Applegate, L. A., Baldini, N., Cenni, E., Gomez-Barrena, E., Granchi, D., Kassem, M., Konttinen, Y. T., Mustafa, K. A., Pioletti, D. P., Sillat, T. & Finne-Wistrand, A., 2011, In : Journal of Cellular and Molecular Medicine. 15, 4, p. 718-746

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
Fetal Stem Cells
Fracture Healing
Platelet-Rich Plasma
Tissue Engineering

Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

D'Andrea, F. P., Safwat, A., Kassem, M., Gautier, L., Overgaard, J. & Horsman, M. R., 1. Jun 2011, In : Radiotherapy & Oncology. 99, 3, p. 373-8 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
Seeds
Clone Cells
Population

CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization

Tormin, A., Li, O., Brune, J. C., Walsh, S., Schütz, B., Ehinger, M., Ditzel, N., Kassem, M. & Scheding, S., 2011, In : Blood. 117, 19, p. 5067-77 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
Population
Stromal Cells
Cultured Cells
Fibroblasts

Cell shape and spreading of stromal (mesenchymal) stem cells cultured on fibronectin coated gold and hydroxyapatite surfaces

Dolatshahi-Pirouz, A., Jensen, T. H. L., Kolind, K., Bünger, C., Kassem, M., Foss, M. & Besenbacher, F., 2011, In : Colloids and Surfaces B: Biointerfaces. 84, 1, p. 18-25 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Shape
stem cells
Durapatite
Stem cells
Mesenchymal Stromal Cells

Circulating osteogenic cells: implications for injury, repair, and regeneration

Pignolo, R. J. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1685-93 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Wounds and Injuries
Osteogenesis
Reading

CXCR4 expression in human mesenchymal stem cells enhances in vitro migration

Andersen, R. K., Clausen, C., Jørgensen, F., Holst, B., Zaher, W. & Kassem, M., 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction

Burns, J. S., Kristiansen, M., Kristensen, L. P., Larsen, K. H., Nielsen, M. O., Christiansen, H., Nehlin, J., Andersen, J. S. & Kassem, M., 1. Jan 2011, In : P L o S One. 6, 7, p. e21888

Research output: Contribution to journalJournal articleResearchpeer-review

Galectin 1
angiogenesis
Stem cells
Mesenchymal Stromal Cells
stem cells

Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway

Chen, L., Qanie, D., Jafari, A., Taipaleenmaki, H., Jensen, C. H., Säämänen, A-M., Sanz, M. L. N., Laborda, J., Abdallah, B. M. & Kassem, M., 2011, In : Journal of Biological Chemistry. 286, 37, p. 32140-9 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell Differentiation
Phosphotransferases
Antigens
Chondrogenesis
Fibronectins

Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells

Andersen, D. C., Kortesidis, A., Zannettino, A. C. W., Kratchmarova, I., Chen, L., Jensen, O. N., Teisner, B., Gronthos, S., Jensen, C. H. & Kassem, M., 2011, In : Molecules and Cells. 32, 2, p. 133-142 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
HLA-DRB1 Chains
Alkaline Phosphatase
Flow Cytometry
Membrane Proteins

Direct differentiation of human embryonic stem cells toward osteoblasts and chondrocytes through an intermediate mesenchyme progenitor lineage.

Abdallah, B., Harkness, L., Mahmood, A. & Kassem, M., 2011, Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis. Atwood, C. (ed.). InTech - Open Access Publisher, p. 607-620

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice

Abdallah, B. M., Ditzel, N., Mahmood, A., Isa, A., Traustadottir, G. A., Schilling, A. F., Ruiz-Hidalgo, M-J., Laborda, J., Amling, M. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1457-71 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Estrogens
Osteogenesis
Osteoblasts
Postmenopausal Osteoporosis
Ovariectomy

En Kur mod Alzheimers sygdom

Kassem, M., 2011, In : Sund i syd. 1, 5, p. 6-7 2 p.

Research output: Contribution to journalContribution to newspaper - Newspaper articleCommunication

Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

Abdallah, B. M., Bay-Jensen, A-C., Srinivasan, B., Tabassi, N. C., Garnero, P., Delaissé, J-M., Khosla, S. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 10, p. 2548-2551

Research output: Contribution to journalJournal articleResearchpeer-review

Estrogens
Estrogen Replacement Therapy
Osteocalcin
Serum

Extrinsic Mechanisms Involved in Age-Related Defective Bone Formation

Trinquier, A. M-P. E. & Kassem, M., 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 3, p. 600-609 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Osteogenesis
Osteoblasts
PubMed
Rodentia
Population

Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes

Bjerre, L., Bünger, C., Baatrup, A., Kassem, M. & Mygind, T., 2011, In : Journal of Biomedical Materials Research. Part A. 97A, 3, p. 251-63 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Hydroxyapatite
Cell culture
Scaffolds
Pore size

HLA-B expression during diffenrentiation from embryonic stem cells to lymphocytes, adipocytes and osteocytes

Sabir, H. J., Isa, A., Nehlin, J., Qanie, D. W. M., Harkness, L., Prokhorova, T., Kassem, M. & Barington, T., 21. Sep 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Human Serum is as Efficient as Fetal Bovine Serum in Supporting Proliferation and Differentiation of Human Multipotent Stromal (Mesenchymal) Stem Cells In Vitro and In Vivo

Aldahmash, A., Haack-Sørensen, M., Al-Nbaheen, M., Harkness, L., Abdallah, B. M. & Kassem, M., 2011, In : Stem Cell Reviews. 7, 4, p. 860-868

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
Serum
In Vitro Techniques
Lipoprotein Lipase
Telomerase

Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5

Nielsen, M. F., Andersen, T. E., Gossiel, F., Hansen, S., Bollerslev, J., Van Hul, W., Eastell, R., Kassem, M. & Brixen, K., 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1721-1728 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Bone Density
Mutation
Forearm
Serum
Hip

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

Eskildsen, T., Taipaleenmäki, H., Stenvang, J., Abdallah, B. M., Ditzel, N., Nossent, A. Y., Bak, M., Kauppinen, S. & Kassem, M., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-44 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Mesenchymal Stromal Cells
Osteoblasts
Osteogenesis
Luciferases

New factors controlling the balance between osteoblastogenesis and adipogenesis

Abdallah, B. M. & Kassem, M., 2011, In : Bone. 50, 2, p. 540-5 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Adipogenesis
Adiposity
Osteoblasts
Adipocytes
Population

Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Marie, P. J. & Kassem, M., 2011, In : European Journal of Endocrinology. 165, 1, p. 1-10 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Osteoblasts
Osteogenesis
Pharmaceutical Preparations

PDX1- and NGN3-mediated in vitro reprogramming of human bone marrow-derived mesenchymal stromal cells into pancreatic endocrine lineages

Limbert, C., Päth, G., Ebert, R., Rothhammer, V., Kassem, M., Jakob, F. & Seufert, J., 2011, In : Cytotherapy. 13, 7, p. 802-13 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mesenchymal Stromal Cells
In Vitro Techniques

Selective isolation and differentiation of a stromal population of human embryonic stem cells with osteogenic potential

Harkness, L. M., Mahmood, A., Ditzel, N., Abdallah, B. M., Nygaard, J. V. & Kassem, M., 2011, In : Bone. 48, 1, p. 231-241

Research output: Contribution to journalJournal articleResearchpeer-review

Population
Stromal Cells
Fibroblasts
Cell Line
Regenerative Medicine

Self-assembled composite matrix in a hierarchical 3D scaffold for bone tissue engineering

Chen, M., Le, D. Q. S., Baatrup, A., Nygaard, J. V., Hein, S., Bjerre, L., Kassem, M., Zou, X. & Bünger, C., 2011, In : Acta Biomaterialia. 7, 5, p. 2244-2255 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Polycaprolactone
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

Kassem, M. & Trinquier, A. M-P. E., 2011, In : Aging Cell. 10, 2, p. 191-7 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Osteoblasts
Cell Aging
Skeleton
Hormones

Separate developmental programs for HLA-A and -B expression during diffenrentiation from embryonic stem cells to lymphocytes, adipocytes and osteocytes

Sabir, H. J., Isa, A., Nehlin, J., Qanie, D. W. M., M, L., Prokhorova, T., Kassem, M. & Barington, T., 28. Apr 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

Heinonen, J., Taipaleenmäki, H., Roering, P., Takatalo, M., Harkness, L., Sandholm, J., Uusitalo-Järvinen, H., Kassem, M., Kiviranta, I., Laitala-Leinonen, T. & Säämänen, A-M., 2011, In : Osteoarthritis and Cartilage. 19, 8, p. 1026-35 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cartilage
Chondrocytes
Joints
Membranes
Chondrogenesis

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation

Rigbolt, K. T. G., Prokhorova, T. A., Akimov, V., Henningsen, J., Johansen, P. T., Kratchmarova, I., Kassem, M., Mann, M., Olsen, J. V. & Blagoev, B., 2011, In : Science Signaling. 4, 164, p. rs3

Research output: Contribution to journalJournal articleResearchpeer-review

Phosphorylation
Proteome
Stem cells
Cell Differentiation
Methyltransferases

Telomerase-Deficient Mice Exhibit Bone Loss Owing to Defects in Osteoblasts and Increased Osteoclastogenesis by Inflammatory Microenvironment

Saeed, H., Abdallah, B. M., Ditzel, N., Catala-Lehnen, P., Qiu, W. M., Amling, M. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1494-1505 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

TGFb signalling inhibits DLK1 expression during chondrogenesis in vitro

Harkness, L., Taipaleenmaki, H., Saamanen, A-M., Kassem, M. & Abdallah, B., 15. Jun 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Chondrogenesis
Chondrocytes
Fibroblasts
Limb Buds
Cell Lineage