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Author

  • Moustapha Kassem
2018

Establishing lobular-like and interlobular-like fibroblast cell lines from human breast reduction mammoplasties

Morsing, M., Jafari, A., Kassem, M., Petersen, O. W. & Ronnov-Jessen, L., Jul 2018, In : Cancer research. 78, Suppl. 13, 1010.

Research output: Contribution to journalConference abstract in journalResearch

2019

Strontium functionalized scaffold for bone tissue engineering

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M., 1. Jan 2019, In : Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems. 94, p. 509-515

Research output: Contribution to journalJournal articleResearchpeer-review

2011

PDX1- and NGN3-mediated in vitro reprogramming of human bone marrow-derived mesenchymal stromal cells into pancreatic endocrine lineages

Limbert, C., Päth, G., Ebert, R., Rothhammer, V., Kassem, M., Jakob, F. & Seufert, J., 2011, In : Cytotherapy. 13, 7, p. 802-13 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2016

Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial

Fuleihan G, EI-H., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Rahme, M., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T. & Kassir, M-F., Aug 2016, In : The American Journal of Clinical Nutrition. 104, 2, p. 315-323

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Surface-modified functionalized polycaprolactone scaffolds for bone repair: In vitro and in vivo experiments

Jensen, J., Rolfing, J. H. D., Svend Le, D. Q., Kristiansen, A. A., Nygaard, J. V., Bjerre Hokland, L., Bendtsen, M., Kassem, M., Lysdahl, H. & Bunger, C. E., Sep 2014, In : Journal of Biomedical Materials Research. Part A. 102, 9, p. 2993-3003 11 p., 24123983.

Research output: Contribution to journalJournal articleResearchpeer-review

File
911 Downloads (Pure)
2016

Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

Morsing, M., Klitgaard, M. C., Jafari, A., Villadsen, R., Kassem, M., Petersen, O. W. & Rønnov-Jessen, L., 3. Nov 2016, In : Breast Cancer Research (Online). 18, 108.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
188 Downloads (Pure)
2014

Establishing quiescence in human bone marrow stromal stem cells leads to enhanced osteoblast marker expression

Harkness, L., Rumman, M., Kassem, M. & Dhawan, J., 18. Jun 2014. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2016

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization

Elsafadi, E., Manikandan, M., Dawud, R. A., Alajez, N. M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Mahmood, A., 2016, In : Cell Death & Disease. 7, p. e2321 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
181 Downloads (Pure)
2011

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice

Abdallah, B. M., Ditzel, N., Mahmood, A., Isa, A., Traustadottir, G. A., Schilling, A. F., Ruiz-Hidalgo, M-J., Laborda, J., Amling, M. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1457-71 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2016

Aging and bone

Gimble, J. M., Floyd, Z. E., Kassem, M. & Nuttall, M. E., 2016, Osteoporosis in Older Persons: Advances in Pathophysiology and Therapeutic Approaches. Duque, G. & Kiel, D. P. (eds.). 2. ed. Springer, p. 23-42

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

2018

Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress prosurvival signalling pathways

Vishnubalaji, R., Manikandan, M., Fahad, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2. Mar 2018, In : OncoTarget. 9, 17, p. 13551-13564

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
220 Downloads (Pure)
2014

Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications.

Jafari, A., Harkness, L., Zaher, W. & Kassem, M., May 2014, Adult Stem Cells, Stem Cell Biology and Regenerative Medicine. Turksen, K. (ed.). Springer Science+Business Media, p. 359-373 15 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

2013

Telomere dysfunction leads to changes in microglial numbers and morphology in a mouse model of premature aging. Glia, Volume 61, Issue Suppl 1, S157.

Khan, A. M., Babcock, A., Kassem, M. & Finsen, B., 2013.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2011

Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway

Chen, L., Qanie, D., Jafari, A., Taipaleenmaki, H., Jensen, C. H., Säämänen, A-M., Sanz, M. L. N., Laborda, J., Abdallah, B. M. & Kassem, M., 2011, In : Journal of Biological Chemistry. 286, 37, p. 32140-9 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes

Bjerre, L., Bünger, C., Baatrup, A., Kassem, M. & Mygind, T., 2011, In : Journal of Biomedical Materials Research. Part A. 97A, 3, p. 251-63 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells

Al-toub, M., Almusa, A., Almajed, M., Al-Nbaheen, M., Kassem, M., Aldahmash, A. & Alajez, N., 2013, In : Stem Cell Research & Therapy. 4, 114, 19 p., 24405819.

Research output: Contribution to journalJournal articleResearchpeer-review

File
518 Downloads (Pure)
2017

CHD1 regulates cell fate determination by activation of differentiation-induced genes

Baumgart, S. J., Najafova, Z., Hossan, T., Xie, W., Nagarajan, S., Kari, V., Ditzel, N., Kassem, M. & Johnsen, S. A., 2017, In : Nucleic Acids Research. 45, 13, p. 7722-7735

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
203 Downloads (Pure)
2018

NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC

Manikandan, M., Abuelreich, S., Elsafadi, M., Alsalman, H., Almalak, H., Siyal, A., Hashmi, J. A., Aldahmash, A., Kassem, M., Alfayez, M. & Mahmood, A., 1. Nov 2018, In : Differentiation. 104, p. 36-41

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
97 Downloads (Pure)
2013

Sphingosine 1 Phosphate (S1P) Receptors 1 and 2 Coordinately Induce Osteoblast Migration Through S1P Activation of Complementary Kinase Pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2013, In : Journal of Biological Chemistry. 288, p. 5398-5406

Research output: Contribution to journalJournal articleResearchpeer-review

2011

CXCR4 expression in human mesenchymal stem cells enhances in vitro migration

Andersen, R. K., Clausen, C., Jørgensen, F., Holst, B., Zaher, W. & Kassem, M., 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

2017

The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo

Bonde Jensen, M., Slots, C., Ditzel, N., Hedegaard, M. A. B., Andersen, T. E., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2. Nov 2017. 1 p.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2015

Proteomic Validation of Transcript Isoforms, Including Those Assembled from RNA-Seq Data

Tay, A. P., Pang, C. N. I., Twine, N. A., Hart-Smith, G., Harkness, L., Kassem, M. & Wilkins, M. R., 2015, In : Journal of Proteome Research. 14, 9, p. 3541-3554

Research output: Contribution to journalJournal articleResearchpeer-review

2014

miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation

Qiu, W. & Kassem, M., Sep 2014, In : BBA General Subjects. 1843, 9, p. 2114–2121

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells

Andersen, D. C., Kortesidis, A., Zannettino, A. C. W., Kratchmarova, I., Chen, L., Jensen, O. N., Teisner, B., Gronthos, S., Jensen, C. H. & Kassem, M., 2011, In : Molecules and Cells. 32, 2, p. 133-142 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Separate Developmental Programs for HLA-A and -B Cell Surface Expression during Differentiation from Embryonic Stem Cells to Lymphocytes, Adipocytes and Osteoblasts

Sabir, H. J., Nehlin, J. O., Qanie, D., Harkness, L., Prokhorova, T. A., Blagoev, B., Kassem, M., Isa, A. & Barington, T., 2013, In : P L o S One. 8, 1, p. e54366

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Telomerase-Deficient Mice Exhibit Bone Loss Owing to Defects in Osteoblasts and Increased Osteoclastogenesis by Inflammatory Microenvironment

Saeed, H., Abdallah, B. M., Ditzel, N., Catala-Lehnen, P., Qiu, W. M., Amling, M. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1494-1505 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2015

Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling.

Jafari, A., Siersbæk, M., Chen, L., Qanie, D. W. M., Zaher, W., Abdallah, B. & Kassem, M., 2015, In : Stem Cells. 33, 7, p. 2219–2231

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
2011

Circulating osteogenic cells: implications for injury, repair, and regeneration

Pignolo, R. J. & Kassem, M., 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1685-93 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

Heinonen, J., Taipaleenmäki, H., Roering, P., Takatalo, M., Harkness, L., Sandholm, J., Uusitalo-Järvinen, H., Kassem, M., Kiviranta, I., Laitala-Leinonen, T. & Säämänen, A-M., 2011, In : Osteoarthritis and Cartilage. 19, 8, p. 1026-35 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2015

Anabolic compounds for treating and preventing bone loss diseases

Jafari, A., Chen, L., Kassem, M. & Abdallah, B., 7. May 2015, Patent No. WO2013167475 (A1), 7. May 2015, Priority date 3. May 2013, Priority No. US201314399726

Research output: Patent

2020

Identification of osteolineage cell-derived extracellular vesicle cargo implicated in hematopoietic support

Morhayim, J., Ghebes, C. A., Erkeland, S. J., ter Borg, M. N. D., Hoogenboezem, R. M., Bindels, E. M. J., van Alphen, F. P. J., Kassem, M., van Wijnen, A. J., Cornelissen, J. J., van Leeuwen, J. P., van der Eerden, B. C. J., Voermans, C., van de Peppel, J. & Braakman, E., 1. Apr 2020, In : FASEB Journal. 34, 4, p. 5435-5452

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
8 Downloads (Pure)
2015

Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells

Chen, L., Shi, K., Frary, C., Ditzel, N., Hu, H., Qiu, W. & Kassem, M., 2015, In : Stem Cell Research. 15, 2, p. 281-289

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
284 Downloads (Pure)
2019

ESTABLISHMENT OF A KNOCKDOWN MODEL FOR UNRAVELLING THE PATHOGENESIS OF MANTLE CELL LYMPHOMA

Valentin Hansen, S., Cédile, O., Hansen, M. C., Christensen, J. H., Chen, L., Kassem, M., Abildgaard, N. & Nyvold, C. G., Jun 2019.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2020

Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent manner

Elsafadi, M., Manikandan, M., Almalki, S., Mahmood, A., Shinwari, T., Vishnubalaji, R., Mobarak, M., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 1. May 2020, In : Cell Death and Disease. 11, 5, 13 p., 341.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2017

MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3

Elsafadi, M., Manikandan, M., Alajez, N. M., Hamam, R., Dawud, R. A., Aldahmash, A., Iqbal, Z., Alfayez, M., Kassem, M. & Mahmood, A., 2017, In : Stem Cell Research. 20, p. 94-104

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
385 Downloads (Pure)
2016

Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain of function mutations

Galan-Diez, M., Isa, A., Ponzetti, M., Nielsen, M. F. M., Kassem, M. & Kousteni, S., 2016, In : BBA General Subjects. 1863, 3, p. 490-8

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high bone mass phenotype due to a mutation in Lrp5

Nielsen, M. F., Andersen, T. E., Gossiel, F., Hansen, S., Bollerslev, J., Van Hul, W., Eastell, R., Kassem, M. & Brixen, K., 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1721-1728 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2016

Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells

Twine, N. A., Harkness, L., Kassem, M. & Wilkins, M. R., 2016, In : BMC Genomics. 17, 15 p., 872.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
203 Downloads (Pure)

CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

Harkness, L., Zaher, W., Ditzel, N., Isa, A. & Kassem, M., 2016, In : Stem Cell Research & Therapy. 7, 1, p. 4-16 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
145 Downloads (Pure)
2015

Paolo Bianco (1955-2015)

Kassem, M. & Jakob, F., 2015, In : Stem Cell Research. 15, 3, p. 742 1 p.

Research output: Contribution to journalComment/debateCommunication

Open Access
File
100 Downloads (Pure)
2013

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential

Al-Nbaheen, M., Vishnubalaji, R., Ali, D., Bouslimi, A., Al-Jassir, F., Megges, M., Prigione, A., Adjaye, J., Kassem, M. & Aldahmash, A., 14. Apr 2013, In : Stem Cell Reviews. 9, 1, p. 32-43

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Human Serum is as Efficient as Fetal Bovine Serum in Supporting Proliferation and Differentiation of Human Multipotent Stromal (Mesenchymal) Stem Cells In Vitro and In Vivo

Aldahmash, A., Haack-Sørensen, M., Al-Nbaheen, M., Harkness, L., Abdallah, B. M. & Kassem, M., 2011, In : Stem Cell Reviews. 7, 4, p. 860-868

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

Eskildsen, T., Taipaleenmäki, H., Stenvang, J., Abdallah, B. M., Ditzel, N., Nossent, A. Y., Bak, M., Kauppinen, S. & Kassem, M., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-44 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

Marie, P. J. & Kassem, M., 2011, In : European Journal of Endocrinology. 165, 1, p. 1-10 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2020

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., 7. Jan 2020, In : Nature Communications. 11, 13 p., 87.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
41 Downloads (Pure)
2016

Aarhus Regenerative Orthopaedics Symposium (AROS): Regeneration in the ageing population

Foldager, C. B., Bendtsen, M., Berg, L. C., Brinchmann, J. E., Brittberg, M., Bunger, C., Canseco, J., Chen, L., Christensen, B., Colombier, P., Deleuran, B. W., Edwards, J., Elmengaard, B., Farr, J., Gatenholm, B., Gomoll, A. H., Hui, J. H., Jakobsen, R. B., Jørgensen, N. L., Kassem, M. & 18 others, Koch, T., Kold, S., Krogsgaard, M. R., Lauridsen, H., Le, D., Le Visage, C., Lind, M., Nygaard, J. V., Olesen, M. L., Pedersen, M., Rathcke, M. W., Richardson, J. B., Roberts, S., Rölfing, J. D., Sakai, D., Seong Toh, W., Urban, J. & Spector, M., 16. Dec 2016, In : Acta Orthopaedica (Print Edition). 87, sup363, p. 1-5

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
123 Downloads (Pure)
2019

Lansoprazole inhibits the cysteine protease legumain by binding to the active site

Bosnjak, T., Solberg, R., Hemati, P. D., Jafari, A., Kassem, M. & Johansen, H. T., Aug 2019, In : Basic & Clinical Pharmacology & Toxicology. 125, 2, p. 89-99

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
36 Downloads (Pure)
2017

Cross-border biobanking: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Waizner, K., Wendlandt, R., Zweig, W., Kowal, J. M., Haakonsson, A., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H. & 12 others, Duckert, R., Kroeger, I., Stueck, G., Kessel, S., Hecht, M., Frahm, T., Eckers, A., Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 2017. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2015

Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

Rumman, M., Dhawan, J. & Kassem, M., 2015, In : Stem Cells. 33, 10, p. 2903-12

Research output: Contribution to journalJournal articleResearchpeer-review